[Lamotrigine in the therapy of resistant epilepsy].

Abstract

OBJECTIVE:

To evaluate the efficacy of lamotrigine as single agent in patients with refractory epilepsy.

MATERIALS AND METHODS:

Forty-seven adult patients with refractory epilepsy, in the initial phase received carbamazepine (1208 +/- 82.9 mg/day) plus lamotrigine (561.7 +/- 76.8 mg/day); during the second phase they received lamotrigine alone (206.4 +/- 44.4 mg/day).

RESULTS:

Lamotrigine monotherapy significantly improved the number of seizures per week in comparison to lamotrigine combined with carbamazepine (p < 0.0001).

CONCLUSIONS:

Lamotrigine as single agent is more effective than carbamazepine + lamotrigine in patients with refractory epilepsy.

• Authors: F De Romanis, N Sopranzi
• Journal: La Clinica terapeutica (Clin Ter) 1999 Jul-Aug Vol. 150 Issue 4 Pg. 279-82 ISSN: 0009-9074 [Print] Italy
• Vernacular Title: Lamotrigina nella terapia dell'epilessia resistente.
• PMID: 10605165 (Publication Type: Clinical Trial, Clinical Trial, Phase II, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anticonvulsants
• Triazines
• Carbamazepine
• Lamotrigine

Topics

• Adolescent
• Adult
• Anticonvulsants (pharmacology, therapeutic use)
• Carbamazepine (pharmacology, therapeutic use)
• Drug Therapy, Combination
• Epilepsy (drug therapy)
• Female
• Humans
• Lamotrigine
• Male
• Middle Aged
• Triazines (pharmacology, therapeutic use)