Selective beta2-adrenoceptor agonist enhances sensitivity to cisplatin in non-small cell lung cancer cell line.

Abstract

Cisplatin is a key drug in chemotherapy for lung cancer. It has been reported that intracellular accumulation of cisplatin is an important step as a determinant for resistance to cisplatin, which may be modulated by Na+, K+-ATPase activity. And it has been reported that isoproterenol, a beta-adrenoceptor agonist, enhances sensitivity to cisplatin in non-small cell lung cancer (NSCLC) cell lines. In this study, the effects of the selective beta1, beta2, and beta3-adrenoceptor agonists on membrane Na+, K+-ATPase activity and sensitivity to cisplatin were evaluated using human non-small cell lung cancer cell line. In the NSCLC cell line, sensitivity to cisplatin was improved by treatment with procaterol, a selective beta2-adrenoceptor agonist. Na+, K+-ATPase was activated and intracellular accumulation of cisplatin increased with the treatment. However, beta1 or beta3-adrenoceptor agonist did not modulate sensitivity to cisplatin or Na+, K+-ATPase activity. These results suggest that beta2-adrenoceptor may be one of the determinants for sensitivity to cisplatin in NSCLC. Exogenous beta2-adrenoceptor agonists may improve the antitumor effect of chemotherapy involving cisplatin.

• Authors: T Bando, M Fujimura, K Kasahara, T Ueno, T Matsuda
• Journal: Oncology reports (Oncol Rep) 2000 Jan-Feb Vol. 7 Issue 1 Pg. 49-52 ISSN: 1021-335X [Print] Greece
• PMID: 10601590 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-2 Receptor Agonists
• Adrenergic beta-Agonists
• Antineoplastic Agents
• Catechols
• Ethanolamines
• SM 11044
• Serine
• Sodium-Potassium-Exchanging ATPase
• Cisplatin
• Potassium
• denopamine
• Procaterol

Topics

• Adrenergic beta-2 Receptor Agonists
• Adrenergic beta-Agonists (pharmacology)
• Antineoplastic Agents (pharmacology)
• Carcinoma, Non-Small-Cell Lung (drug therapy, pathology)
• Catechols (pharmacology)
• Cisplatin (pharmacokinetics, pharmacology)
• Drug Synergism
• Ethanolamines (pharmacology)
• Humans
• Lung Neoplasms (drug therapy, pathology)
• Potassium (metabolism)
• Procaterol (pharmacology)
• Serine (analogs & derivatives, pharmacology)
• Sodium-Potassium-Exchanging ATPase (metabolism)
• Tumor Cells, Cultured