Asthma therapy with agents preventing leukotriene synthesis or action.

Abstract

Elucidation of the biochemistry of leukotriene production and the pharmacology of its actions has led to the development of a number of therapeutic agents shown to be of value in the treatment of asthma. These agents either prevent the synthesis of the leukotrienes, by preventing the action of the 5-lipoxygenase-activating protein or the catalytic action of the 5-lipoxygenase, or by inhibiting the action of leukotrienes at the CysLT1 receptor. Numerous clinical trials in exercise-induced asthma, allergen-induced asthma, aspirin-induced asthma, and spontaneously occurring asthmatic episodes have indicated that these agents are safe and effective asthma treatments.

• Authors: J M Drazen
• Journal: Proceedings of the Association of American Physicians (Proc Assoc Am Physicians) 1999 Nov-Dec Vol. 111 Issue 6 Pg. 547-59 ISSN: 1081-650X [Print] United States
• PMID: 10591083 (Publication Type: Journal Article, Review)

Chemical References

• Acetates
• Allergens
• Anti-Asthmatic Agents
• Chromones
• Cyclopropanes
• Indoles
• Leukotriene Antagonists
• Leukotrienes
• Lipoxygenase Inhibitors
• Membrane Lipids
• Membrane Proteins
• Phenylcarbamates
• Quinolines
• Receptors, Leukotriene
• Sulfides
• Sulfonamides
• Tosyl Compounds
• Arachidonic Acid
• cysteinyl leukotriene receptor 2
• Arachidonate 5-Lipoxygenase
• Phospholipases A
• leukotriene D4 receptor
• montelukast
• Aspirin
• pranlukast
• zileuton
• Hydroxyurea
• zafirlukast

Topics

• Acetates (pharmacology, therapeutic use)
• Allergens (adverse effects)
• Anti-Asthmatic Agents (classification, pharmacology, therapeutic use)
• Arachidonate 5-Lipoxygenase (physiology)
• Arachidonic Acid (metabolism)
• Aspirin (adverse effects)
• Asthma (drug therapy, etiology, metabolism)
• Asthma, Exercise-Induced (drug therapy, metabolism)
• Bronchoconstriction (drug effects)
• Chromones (pharmacology, therapeutic use)
• Clinical Trials as Topic
• Cyclopropanes
• Double-Blind Method
• Humans
• Hydroxyurea (analogs & derivatives, pharmacology, therapeutic use)
• Indoles
• Leukotriene Antagonists (pharmacology, therapeutic use)
• Leukotrienes (biosynthesis)
• Lipoxygenase Inhibitors (pharmacology, therapeutic use)
• Membrane Lipids (metabolism)
• Membrane Proteins
• Phenylcarbamates
• Phospholipases A (metabolism)
• Quinolines (pharmacology, therapeutic use)
• Randomized Controlled Trials as Topic
• Receptors, Leukotriene
• Safety
• Sulfides
• Sulfonamides
• Tosyl Compounds (pharmacology, therapeutic use)