HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The antiangiogenic agent linomide inhibits the growth rate of von Hippel-Lindau paraganglioma xenografts to mice.

Abstract
The aim of this study was to ascertain the potential usefulness of the antiangiogenic compound linomide for treatment of von Hippel-Lindau (VHL)-related tumors. Paraganglioma tissue fragments obtained at surgery from a VHL type 2a patient were transplanted s.c. to male BALB/c nu/nu (nude) mice: (a) 2-3-mm fragments for "prevention" experiments; and (b) 2-3-mm fragments allowed to grow to 1 cm for "intervention" studies. Both groups received either 0.5 mg/ml linomide in drinking water or acidified water and were followed until tumor diameter reached 3 cm or for 4 weeks. In both the prevention and intervention experiments, a significant diminution of tumor size and weight was observed in the drug-treated animals. In vivo nuclear magnetic resonance analysis of tumor blood flow in linomide-treated animals showed localization of blood vessels almost exclusively to the periphery of the poorly vascularized tumors with a significant reduction of both vascular functionality and vasodilation. Histological examination of tumors from linomide-treated animals revealed marked avascularity. Treated animals also displayed a 2.4-fold reduction of tumor vascular endothelial growth factor mRNA levels. Taken together, our data indicate that in VHL disease, therapy directed at inhibition of constitutively expressed VEGF induction of angiogenesis by VHL tumors may constitute an effective medical treatment.
AuthorsD J Gross, I Reibstein, L Weiss, S Slavin, I Stein, M Neeman, R Abramovitch, L E Benjamin
JournalClinical cancer research : an official journal of the American Association for Cancer Research (Clin Cancer Res) Vol. 5 Issue 11 Pg. 3669-75 (Nov 1999) ISSN: 1078-0432 [Print] United States
PMID10589785 (Publication Type: Journal Article)
Chemical References
  • Angiogenesis Inhibitors
  • Hydroxyquinolines
  • roquinimex
Topics
  • Administration, Oral
  • Angiogenesis Inhibitors (therapeutic use)
  • Animals
  • Cell Division (drug effects)
  • Humans
  • Hydroxyquinolines (administration & dosage, therapeutic use)
  • Magnetic Resonance Imaging
  • Male
  • Mice
  • Mice, Nude
  • Neovascularization, Pathologic (pathology, prevention & control)
  • Paraganglioma (blood supply, drug therapy, pathology)
  • Transplantation, Heterologous
  • Tumor Cells, Cultured
  • von Hippel-Lindau Disease (complications, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: