Abstract |
Five fractions ( hexane, chloroform, ethylacetate, methanol and water) of Icacina trichantha tuber were obtained by gradient solvent extraction and tested for their ability to inhibit the Croton oil-induced ear edema in mice. The most active fraction was the chloroform one which significantly inhibited ear edema in a dose-dependent manner, showing an ID50 (dose giving 50% edema inhibition) of 107 micrograms/cm2. The ID50 of the reference drug indomethacin was 93 micrograms/cm2. The chloroform fraction significantly reduced also the carrageenin-induced paw edema in rats, after oral adiminstration: 50, 100 or 200 mg/kg of the fraction reduced the global edematous response by 15, 20 or 34%, whereas 10 mg/kg of indomethacin induced 40% inhibition.
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Authors | I U Asuzu, S Sosa, R Della Loggia |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 6
Issue 4
Pg. 267-72
(Oct 1999)
ISSN: 0944-7113 [Print] Germany |
PMID | 10589446
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Irritants
- Plant Extracts
- Croton Oil
- Carrageenan
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Topics |
- Animals
- Anti-Inflammatory Agents
(isolation & purification, pharmacology)
- Carrageenan
- Chromatography, High Pressure Liquid
- Croton Oil
- Dose-Response Relationship, Drug
- Ear
- Edema
(prevention & control)
- Foot
- Inflammation
- Irritants
- Male
- Mice
- Plant Extracts
(isolation & purification, pharmacology)
- Plant Roots
(chemistry)
- Plants, Medicinal
- Rats
- Rats, Sprague-Dawley
- Skin
(drug effects)
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