T1 and T2 lip cancer: a superselective method of facial arterial infusion therapy--preliminary experience.

Abstract

PURPOSE:

To formulate and evaluate a facial arterial infusion chemotherapy for squamous cell lip carcinoma.

MATERIALS AND METHODS:

The study included six patients (age range, 46-84 years) with squamous cell carcinoma of the lower lip. There were two T1 tumors, three T2 tumors, and one T1-compatible postoperative recurrent tumor. A 4-F, double-lumen balloon catheter was inserted into the external carotid artery through the superficial temporal artery and placed for selective infusion into the tumor-feeding facial artery. Patients received a combination of mitomycin C (4.4 mg/m2 per body surface area) on day 1 and 3.2 mg/m2 of peplomycin sulfate on days 1-7 (22.4 mg/m2 per week), or, when peplomycin sulfate was contraindicated, 16 mg/m2 of cisplatin only on days 1-5 (80 mg/m2 per week). Two to three cycles of chemotherapy were given until tumor disappearance was histologically confirmed.

RESULTS:

Complete tumor disappearance was achieved in all cases. One patient had a self-limiting asthma attack during peplomycin sulfate treatment, and another had transient partial hair loss. No disfigurement, recurrence, or late complications were observed at a mean follow-up of 5.0 years (range, 2.3-11.2 years).

CONCLUSION:

The described facial arterial infusion chemotherapy appears to be a safe and curative treatment for T1 and T2 squamous cell lip carcinomas.

• Authors: K Kishi, M Matsunaka, M Sato, T Sonomura, M Sakurane, K Uede
• Journal: Radiology (Radiology) Vol. 213 Issue 1 Pg. 173-9 (Oct 1999) ISSN: 0033-8419 [Print] United States
• PMID: 10540658 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Mitomycin
• Peplomycin
• Cisplatin

Topics

• Aged
• Aged, 80 and over
• Angiography, Digital Subtraction
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects)
• Carcinoma, Squamous Cell (blood supply, diagnostic imaging, drug therapy)
• Cisplatin (administration & dosage)
• Female
• Humans
• Infusions, Intra-Arterial (adverse effects)
• Lip Neoplasms (blood supply, diagnostic imaging, drug therapy)
• Male
• Maxillary Artery
• Middle Aged
• Mitomycin (administration & dosage)
• Peplomycin (administration & dosage)
• Radiography, Interventional