The neuroprotective effect of a new serotonin receptor agonist, BAY X3702, upon focal ischemic brain damage caused by acute subdural hematoma in the rat.

Abstract

We tested the neuroprotective effect of a novel, high affinity serotonin (5-HT1A) agonist, BAY X3702, in a rat model of acute subdural hematoma (ASDH). Animals were treated with 0.01 mg/kg (n=8), 0.003 mg/kg (n=8) BAY X3702 or vehicle (n=4) 15 min before (i.v.) and after (continuous infusion) injection of 400 microl of autologous blood into the subdural space. The ischemic brain damage at 4 h after ASDH was 59.01+/-39 and 60.8+/-49 mm(3) for the low- and high-dose BAY X3702 group, respectively, which was significantly smaller compared to the vehicle-treated ASDH group (106.2+/-33 mm(3)). The result indicates that this novel, high affinity 5-HT(1A) agonist, BAY X3702, is neuroprotective in this model.

• Authors: B Alessandri, E Tsuchida, R M Bullock
• Journal: Brain research (Brain Res) Vol. 845 Issue 2 Pg. 232-5 (Oct 23 1999) ISSN: 0006-8993 [Print] Netherlands
• PMID: 10536203 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Benzopyrans
• Neuroprotective Agents
• Receptors, Serotonin
• Receptors, Serotonin, 5-HT1
• Serotonin Receptor Agonists
• Thiazoles
• repinotan hydrochloride

Topics

• Animals
• Benzopyrans (pharmacology)
• Brain Ischemia (drug therapy, etiology)
• Dose-Response Relationship, Drug
• Hematoma, Subdural, Acute (complications)
• Male
• Neuroprotective Agents (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Receptors, Serotonin (physiology)
• Receptors, Serotonin, 5-HT1
• Serotonin Receptor Agonists (pharmacology)
• Thiazoles (pharmacology)