Critical role of CD23 in allergen-induced bronchoconstriction in a murine model of allergic asthma.

Abstract

CD23-deficient and anti-CD23 monoclonal antibody-treated mice were used to investigate the role of the low-affinity receptor for IgE (CD23) in allergic airway inflammation and airway hyperresponsiveness (AHR). While there were no significant differences in ovalbumin (OVA)-specific IgE titers and tissue eosinophilia, evaluation of lung function demonstrated that CD23-/- mice showed an increased AHR to methacholine (MCh) when compared to wild-type mice but were completely resistant to the OVA challenge. Anti-CD23 Fab fragment treatment of wild-type mice did not affect the MCh-induced AHR but significantly reduced the OVA-induced airway constriction. These results imply a novel role for CD23 in lung inflammation and suggest that anti-CD23 Fab fragment treatment may be of therapeutic use in allergic asthma.

• Authors: G Dasic, P Juillard, P Graber, S Herren, T Angell, R Knowles, J Y Bonnefoy, M H Kosco-Vilbois, Y Chvatchko
• Journal: European journal of immunology (Eur J Immunol) Vol. 29 Issue 9 Pg. 2957-67 (09 1999) ISSN: 0014-2980 [Print] Germany
• PMID: 10508270 (Publication Type: Journal Article)

Chemical References

• Allergens
• Bronchoconstrictor Agents
• Receptors, Fc
• Receptors, IgE
• Methacholine Chloride
• Immunoglobulin E
• Ovalbumin

Topics

• Allergens (immunology)
• Animals
• Asthma (immunology)
• Bronchoconstriction (immunology)
• Bronchoconstrictor Agents (pharmacology)
• Disease Models, Animal
• Eosinophils (metabolism)
• Female
• Immunoglobulin E (biosynthesis)
• Macrophages, Alveolar (metabolism)
• Methacholine Chloride (pharmacology)
• Mice
• Mice, Congenic
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Ovalbumin (immunology, metabolism)
• Receptors, Fc (metabolism)
• Receptors, IgE (deficiency, metabolism, physiology)
• Time Factors