Abstract |
Forty atopic dogs were studied for 28 days after the oral administration of four randomised treatments: (A) arofylline (1 mg/kg) twice daily for four weeks; (B) prednisone (0.5 mg/kg) twice daily for the first week, once a day during the second week and every 48 hours for the remaining two weeks; (C) prednisone following the same protocol but at a dose of 0.25 mg/kg; or (D) arofylline (1 mg/kg) twice daily for four weeks plus prednisone (0.25 mg/kg) following the same protocol as in (B) and (C). The degree of pruritus and skin lesions and the side effects were evaluated and graded from 0 to 3 before and weekly during the treatments. In all cases there was a progressive clinical improvement in the clinical signs, with no statistical differences among the four treatments. However, many of the dogs treated with arofylline vomited and had adverse gastrointestinal signs.
|
Authors | L Ferrer, J Alberola, M Queralt, P Brazís, R Rabanal, J Llenas, A Puigdemont |
Journal | The Veterinary record
(Vet Rec)
Vol. 145
Issue 7
Pg. 191-4
(Aug 14 1999)
ISSN: 0042-4900 [Print] England |
PMID | 10501583
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Glucocorticoids
- Phosphodiesterase Inhibitors
- Tablets
- Prednisolone
|
Topics |
- Administration, Oral
- Animals
- Dermatitis, Atopic
(drug therapy, veterinary)
- Dog Diseases
(drug therapy)
- Dogs
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Glucocorticoids
(administration & dosage, therapeutic use)
- Male
- Phosphodiesterase Inhibitors
(administration & dosage, therapeutic use)
- Prednisolone
(administration & dosage, therapeutic use)
- Tablets
- Treatment Outcome
|