Comparison of trimethoprim-sulfamethoxazole and ampicillin theraphy for shigellosis in ambulatory.

Abstract

One-hundred seventy-four infants and children with acute diarrhea were treated as ambulatory patients with either ampicillin (100 mg/kg/day orally in four divided doses) or trimethoprim sulfamethoxazole (10 mg TMP and 50 mg SMX/KG/day orally in two divided doses). There were 65 patients with shigellosis. Responses of those treated with TMP/SMX and of those with susceptible Shigella treated with ampicillin were comparable. Patients with resistant organisms failed to respond to ampicillin. All Shigella, including ampicillin-resistant strains, were suseptible in vitro to TMP/SMX, and patients with ampicillin-resistant strains responded favorably to treatment with TMP/SMX. TMP/SMX appears to be the best, currently available drug for the treatment of shigellosis.

• Authors: J D Nelson, H Kusmiesz, L H Jackson
• Journal: The Journal of pediatrics (J Pediatr) Vol. 89 Issue 3 Pg. 491-3 (Sep 1976) ISSN: 0022-3476 [Print] United States
• PMID: 1048183 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Drug Combinations
• Ampicillin
• Trimethoprim
• Sulfamethoxazole

Topics

• Ambulatory Care
• Ampicillin (therapeutic use)
• Child
• Drug Combinations
• Drug Evaluation
• Dysentery, Bacillary (drug therapy)
• Humans
• Infant
• Penicillin Resistance
• Sulfamethoxazole (therapeutic use)
• Texas
• Trimethoprim (therapeutic use)