Action of Sosiho-Tang on systemic and local anaphylaxis by anal administration.

Abstract

The herbal formulation Soshiho-Tang (SS-Tang) has been used against allergic disease for generations, and still occupies an important place in traditional medicine in Korea. Previously, we reported that SS-Tang potently inhibited mast cell- mediated anaphylaxis when orally administered. In this study, we investigated the effect of SS-Tang by anal administration in anaphylaxis responses. SS-Tang dose-dependently inhibited compound 48/80-induced systemic anaphylaxis with doses of 10(-4) to 1 g/kg 1 h before anally administered. Of special note, SS-Tang inhibited systemic anaphylaxis completely with a dose of 1 g/kg. SS-Tang reduced plasma histamine levels induced by compound 48/80 significantly. However, the mortality was 100% when SS-Tang was administered after compound 48/80 treatment. SS-Tang (10(-1) g/kg) also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl IgE antibody by 30.9%. These results provide evidence that anal therapy of SS-Tang may be beneficial in the treatment of systemic and local anaphylaxis.

• Authors: H M Kim, Y Y Kim, H Y Jang, S J Moon, N H An
• Journal: Immunopharmacology and immunotoxicology (Immunopharmacol Immunotoxicol) Vol. 21 Issue 3 Pg. 635-43 (Aug 1999) ISSN: 0892-3973 [Print] England
• PMID: 10466085 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Allergic Agents
• Antibodies, Anti-Idiotypic
• Plant Extracts
• anti-IgE antibodies
• soshiho-tang
• p-Methoxy-N-methylphenethylamine
• Histamine

Topics

• Administration, Rectal
• Anaphylaxis (prevention & control)
• Animals
• Anti-Allergic Agents (administration & dosage)
• Antibodies, Anti-Idiotypic (immunology)
• Histamine (blood)
• Korea
• Medicine, East Asian Traditional
• Mice
• Passive Cutaneous Anaphylaxis (drug effects)
• Plant Extracts
• p-Methoxy-N-methylphenethylamine (pharmacology)