A novel disintegrin salmosin inhibits tumor angiogenesis.

Abstract	Salmosin is a snake venom-derived novel disintegrin that antagonizes platelet aggregation. In this study, we investigated its functional specificity in tumor angiogenesis. Salmosin significantly inhibited bovine capillary endothelial cell proliferation induced by basic fibroblast growth factor but had no effect on normal growth of the cell. The basic fibroblast growth factor-induced in vivo angiogenesis in the chorioallantoic membrane was disrupted by salmosin treatment without affecting normal embryonic angiogenesis. Adhesion of the bovine capillary endothelial cells to vitronectin was also inhibited by the binding of salmosin to the alpha(v)beta3 integrin. Both the metastatic-tumor growth and the solid-tumor growth that developed in mice were effectively suppressed by salmosin treatment. Several lines of experimental evidence strongly suggest that the tumor-specific antiangiogenic activity of salmosin disrupts tumor growth by blocking the alpha(v)beta3 integrin that is expressed on the vascular endothelial cell surface.
Authors	I C Kang, Y D Lee, D S Kim
Journal	Cancer research (Cancer Res) Vol. 59 Issue 15 Pg. 3754-60 (Aug 01 1999) ISSN: 0008-5472 [Print] United States
PMID	10446992 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents Crotalid Venoms Neoplasm Proteins Oligopeptides Receptors, Vitronectin Vitronectin salmosin Fibroblast Growth Factor 2 arginyl-glycyl-aspartic acid
Topics	Allantois (blood supply, drug effects) Animals Antineoplastic Agents (pharmacology, therapeutic use) Carcinoma (pathology, prevention & control, secondary) Cattle Cell Adhesion (drug effects) Cells, Cultured Chick Embryo Chorion (blood supply, drug effects) Crotalid Venoms (pharmacology, therapeutic use) Endothelium, Vascular (cytology) Fibroblast Growth Factor 2 (antagonists & inhibitors, pharmacology) Lung Neoplasms (pathology, prevention & control, secondary) Mice Mice, Inbred C57BL Neoplasm Proteins (antagonists & inhibitors) Neoplasm Transplantation Neovascularization, Pathologic (drug therapy) Oligopeptides Receptors, Vitronectin (antagonists & inhibitors) Tumor Cells, Cultured (drug effects, transplantation) Vitronectin (metabolism)

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