| Abstract |
The efficacy of 5-hydroxytryptamine 1B/1D (5-HT 1B/1D) agonists is related to their inhibitory effects on neurogenic inflammation, mediated through serotoninergic control mechanisms. Recently, a series of oral second generation 5-HT 1B/1D agonists ( eletriptan, naratriptan, rizatriptan and zolmitriptan) have been developed and are reviewed in this paper. Their in vitro and in vivo pharmacological properties, clinical efficacy, drug interactions, and adverse effects are evaluated and compared to the gold standard in the treatment of acute migraine, sumatriptan. |
| Authors | D Deleu, Y Hanssens |
| Journal | Acta neurologica Belgica
(Acta Neurol Belg)
Vol. 99
Issue 2
Pg. 85-95
(Jun 1999)
ISSN: 0300-9009 [Print] Italy |
| PMID | 10427351
(Publication Type: Journal Article, Review)
|
| Chemical References |
- HTR1B protein, human
- Indoles
- Oxazoles
- Oxazolidinones
- Piperidines
- Pyrrolidines
- Receptor, Serotonin, 5-HT1B
- Receptor, Serotonin, 5-HT1D
- Receptors, Serotonin
- Serotonin Receptor Agonists
- Triazoles
- Tryptamines
- Vasoconstrictor Agents
- eletriptan
- zolmitriptan
- rizatriptan
- Sumatriptan
- Propranolol
- naratriptan
|
| Topics |
- Acute Disease
- Animals
- Clinical Trials as Topic
- Coronary Circulation
(drug effects)
- Coronary Vasospasm
(chemically induced)
- Drug Design
- Drug Interactions
- Humans
- Inactivation, Metabolic
- Indoles
(adverse effects, chemistry, therapeutic use)
- Meninges
(blood supply)
- Migraine Disorders
(drug therapy, physiopathology)
- Molecular Structure
- Nociceptors
(physiology)
- Oxazoles
(adverse effects, chemistry, therapeutic use)
- Oxazolidinones
- Piperidines
(adverse effects, chemistry, therapeutic use)
- Propranolol
(pharmacology)
- Pyrrolidines
(adverse effects, chemistry, therapeutic use)
- Randomized Controlled Trials as Topic
- Rats
- Receptor, Serotonin, 5-HT1B
- Receptor, Serotonin, 5-HT1D
- Receptors, Serotonin
(drug effects, physiology)
- Recurrence
- Serotonin Receptor Agonists
(adverse effects, classification, pharmacokinetics, therapeutic use)
- Structure-Activity Relationship
- Sumatriptan
(adverse effects, chemistry, therapeutic use)
- Treatment Outcome
- Triazoles
(adverse effects, chemistry, therapeutic use)
- Tryptamines
- Vasoconstrictor Agents
(adverse effects, therapeutic use)
|
