Abstract |
Exposure to psychological stress increases body temperature (Tb). This stress fever may be immunologically beneficial in some patient populations but detrimental in others (e.g., HIV-infected individuals). For this reason, it is desirable to determine pharmacological methods of preventing stress fever. In rats, stress fever is modeled by exposure to a novel environment or 'open field.' The beta-adrenergic antagonists, nadolol and propranolol, block this stress fever. Neither of these beta-antagonists discriminates between subtypes of beta-receptors. The purpose of this study was to determine the relative contribution of the different beta-receptor types to stress fever using beta1-, beta2-, and beta3-receptor subtype selective antagonists ( atenolol [beta1], ICI-118551 [beta2], and SR 59230A [beta3]) and agonists ( dobutamine [beta1], salbutamol [beta2], and BRL 37344 [beta3]) on the Tb of rats. Tb was measured with a biotelemetry system. Our data suggest that central nervous system beta-receptor blockade with subtype-selective antagonists prevents the stress-induced rise in Tb; however, the beta3-antagonist was effective only at doses that produced hypothermia in a non-stressed control group. The stress-induced fever was mimicked by central nervous system administration of the selective beta2-agonist, salbutamol, and the beta3-agonist, BRL 37344. We hypothesize that the blockade of stress-induced fever by beta-blockers may be due to the sedative actions of these drugs.
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Authors | K P Mayfield, D Soszynski, W Kozak, A Kozak, K Rudolph, M J Kluger |
Journal | Neuroimmunomodulation
(Neuroimmunomodulation)
1999 Jul-Aug
Vol. 6
Issue 4
Pg. 305-17
ISSN: 1021-7401 [Print] Switzerland |
PMID | 10393517
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- 3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate
- Adrenergic beta-Agonists
- Adrenergic beta-Antagonists
- Propanolamines
- Receptors, Adrenergic, beta
- Receptors, Adrenergic, beta-1
- Receptors, Adrenergic, beta-2
- ICI 118551
- Atenolol
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Topics |
- Adrenergic beta-Agonists
(pharmacology)
- Adrenergic beta-Antagonists
(pharmacology)
- Animals
- Atenolol
(pharmacology)
- Body Temperature Regulation
(drug effects, physiology)
- Fever
(etiology, physiopathology)
- Injections, Intraventricular
- Male
- Propanolamines
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Receptors, Adrenergic, beta
(drug effects, physiology)
- Receptors, Adrenergic, beta-1
(drug effects)
- Receptors, Adrenergic, beta-2
(drug effects)
- Stress, Psychological
(complications, physiopathology)
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