Abstract |
Recently, we have developed a method to measure acetylcholinesterase (AChE) activity, a functional marker for cholinergic system, by positron emission tomography (PET) and carbon-11 labeled N-methyl-4-piperidyl acetate. Kinetic analysis of the radioactivity in the brain and the plasma yielded a rate constant "k 3" as an index of AChE activity. The ratios for the k 3 values for the cerebral cortex/thalamus/cerebellum/striatum found in healthy participants were 1/3/8/10, respectively, corresponding well with AChE activity ratios in the brain at necropsy (1/3/8/38), except for the striatum. In 23 healthy volunteers (age range: 24-89 years), there was no age-related decline of k 3 values in the cerebral cortex, suggesting AChE activity is preserved in aged cerebral cortex. In 11 patients with Alzheimer's disease, there was a significant reduction (-24%) of k 3 values in the cerebral cortex and hippocampus, suggesting a loss of ascending cholinergic system from the basal forebrain to the cerebral cortex and hippocampus. In 16 patients with Parkinson's disease, there was a significant reduction (-18%) of k 3 values in the cerebral cortex. In 10 patients with progressive supranuclear palsy, there was a significant reduction (-38%) of k 3 values in the thalamus. This technique is useful for investigating central cholinergic system in neurodegenerative disorders with dementia.
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Authors | H Shinotoh |
Journal | Rinsho shinkeigaku = Clinical neurology
(Rinsho Shinkeigaku)
Vol. 39
Issue 1
Pg. 33-5
(Jan 1999)
ISSN: 0009-918X [Print] Japan |
PMID | 10377794
(Publication Type: Journal Article, Review)
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Chemical References |
- Biomarkers
- Acetylcholinesterase
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Topics |
- Acetylcholinesterase
(analysis)
- Biomarkers
(analysis)
- Brain
(diagnostic imaging, enzymology, physiopathology)
- Cholinergic Fibers
(physiology)
- Humans
- Neurodegenerative Diseases
(diagnostic imaging, physiopathology)
- Tomography, Emission-Computed
(methods)
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