Abstract | BACKGROUND: METHODS: RESULTS: Morphometric results indicated no significant difference in rejection among three groups. However, the extent of graft coronary arteriosclerosis in Group B (1.12 +/- 0.21) and Group C (1.41 +/- 0.19) was significantly less than that seen in Group A (1.72 +/- 0.18) (p < 0.01 andp < 0.05, respectively). Furthermore, the incidence of diseased vessels was significantly less in Group B (29.5% +/- 7.8%) and Group C (42% +/- 9.1%) compared with Group A (69.1% +/- 11%) (p < 0.01 and p < 0.05, respectively). The expression of platelet-derived growth factor A mRNA of cardiac allograft was also significantly suppressed in Group B (25.4 +/- 6.2) and Group C (39.8 +/- 9.4), when compared with Group A (62.2 +/- 12.9) (p < 0.01 and p < 0.05, respectively). CONCLUSION:
|
Authors | M Hachida, X Zhang, H Lu, H Hoshi, H Koyanagi |
Journal | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
(J Heart Lung Transplant)
Vol. 18
Issue 3
Pg. 248-54
(Mar 1999)
ISSN: 1053-2498 [Print] United States |
PMID | 10328151
(Publication Type: Journal Article)
|
Chemical References |
- Immunosuppressive Agents
- Platelet-Derived Growth Factor
- platelet-derived growth factor A
- RNA
- Cyclosporine
|
Topics |
- Animals
- Blotting, Northern
- Coronary Artery Disease
(etiology, pathology, prevention & control)
- Coronary Vessels
(pathology)
- Cyclosporine
(therapeutic use)
- Graft Rejection
- Heart Transplantation
(adverse effects)
- Immunosuppressive Agents
(therapeutic use)
- Male
- Platelet-Derived Growth Factor
(genetics)
- Polymerase Chain Reaction
- RNA
(analysis)
- Rats
- Rats, Inbred Lew
- Rats, Wistar
- Transplantation, Homologous
|