Abstract | BACKGROUND: METHODS: This retrospective review identified 34 patients with ovarian granulosa cell tumors treated with radiation at the University of Texas M. D. Anderson Cancer Center between 1949 and 1988. Fourteen received treatment for clinically measurable disease; 20 received adjuvant radiotherapy after surgery for minimal residual (<1 cm) or microscopic residual disease. The 14 patients with measurable disease formed the basis for this review. RESULTS: Ten of 14 patients were treated with moving-strip whole-abdomen radiation (27-28 Gy), 9 with 60Co, and 1 with 6-MeV photons and a pelvic boost of 28 Gy with 22-25 MeV photons. The other 4 patients were treated with pelvic radiotherapy (45-61 Gy) with 22-25 MeV photons. Six of 14 patients (43%) had a clinical complete response to radiotherapy, with a median follow-up of 13 years (range, 5-21 years). Three of 6 who responded to radiation had relapse 4-5 years later; 2 of these 3 died of disease and 1 was alive with disease at last follow-up. Three responders remain alive without evidence of disease 10-21 years after treatment. The 8 nonresponders had a median survival of 12.3 months (range, 1-60 months). CONCLUSIONS:
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Authors | J K Wolf, J Mullen, P J Eifel, T W Burke, C Levenback, D M Gershenson |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 73
Issue 1
Pg. 35-41
(Apr 1999)
ISSN: 0090-8258 [Print] United States |
PMID | 10094877
(Publication Type: Journal Article, Review)
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Copyright | Copyright 1999 Academic Press. |
Topics |
- Adult
- Aged
- Female
- Follow-Up Studies
- Granulosa Cell Tumor
(mortality, pathology, radiotherapy)
- Humans
- Middle Aged
- Neoplasm Recurrence, Local
(epidemiology)
- Neoplasm Staging
- Ovarian Neoplasms
(mortality, pathology, radiotherapy)
- Radiotherapy
(adverse effects)
- Retrospective Studies
- Survival Rate
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