Abstract | OBJECTIVE: METHODS: RT-PCT was conducted to detect the expression of TGF alpha, TGF beta 1, IL-6, IL-8, bFGF and ANG, and the expression of receptors EGFR, IL-6R and IL-8R; 3H-TdR incorporation assay was used to determine the effects of recombinant TGF alpha, TGF beta 1 and IL-6 on the proliferation of the two cells. RESULTS:
TGF alpha, EGFR, IL-6 and IL-6R were expressed at a higher level in PGbE1 cells than in PGLH7 cells. No significant differences were found in the expression of TGF beta 1, bFGF, IL-8, IL-8R and ANG between the two cells. Recombinant TGF alpha and IL-6 stimulated the proliferation of both cells, while TGF beta 1 had dual effects. CONCLUSION:
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Authors | L Zeng, W Cui, W Fang |
Journal | Zhonghua bing li xue za zhi = Chinese journal of pathology
(Zhonghua Bing Li Xue Za Zhi)
Vol. 26
Issue 2
Pg. 93-5
(Apr 1997)
ISSN: 0529-5807 [Print] China |
PMID | 10072879
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interleukin-6
- Receptors, Interleukin-6
- Recombinant Proteins
- Transforming Growth Factor alpha
- ErbB Receptors
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Topics |
- Carcinoma, Giant Cell
(pathology, secondary)
- Cell Division
(drug effects)
- ErbB Receptors
(biosynthesis)
- Humans
- Interleukin-6
(biosynthesis, pharmacology)
- Lung Neoplasms
(pathology)
- Receptors, Interleukin-6
(biosynthesis)
- Recombinant Proteins
(pharmacology)
- Transforming Growth Factor alpha
(biosynthesis, pharmacology)
- Tumor Cells, Cultured
(drug effects, metabolism)
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