Abstract |
The 5-HT3 receptor antagonists are the most potent antiemetics known at present. Lerisetron is a new 5-HT3 receptor antagonist chemically unrelated to other antagonists like Ondansetron. An emesis model in the dog induced by irradiation with 60Co was used, and 8 Gy were administered over the total body surface. An irradiated control group was established and received no medication, and two irradiated groups received treatment with either Ondansetron or Lerisetron. The 'up-down' technique was employed to determine the effective dose (ED50). A logarithmic-scale was used to increase or decrease the doses in each case. The initial doses were 300 microg/kg for Ondansetron and 100 microg/kg for Lerisetron. All animals in the control group vomited. The ED50 of Ondansetron was 178+/-151 microg/kg body wt and that of Lerisetron was 63+/-18 microg/kg. Lerisetron is more potent and presented less individual variability than Ondansetron, but its antiemetic effects were equally effective.
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Authors | I A Gomez-de-Segura, A G Grande, E De Miguel |
Journal | Acta oncologica (Stockholm, Sweden)
(Acta Oncol)
Vol. 37
Issue 7-8
Pg. 759-63
( 1998)
ISSN: 0284-186X [Print] England |
PMID | 10050999
(Publication Type: Journal Article)
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Chemical References |
- Antiemetics
- Benzimidazoles
- Cobalt Radioisotopes
- Piperidines
- Serotonin Antagonists
- Ondansetron
- lerisetron
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Topics |
- Animals
- Antiemetics
(administration & dosage)
- Benzimidazoles
(administration & dosage)
- Cobalt Radioisotopes
(adverse effects)
- Dogs
- Drug Administration Schedule
- Ondansetron
(administration & dosage)
- Piperidines
(administration & dosage)
- Radiotherapy
(adverse effects)
- Serotonin Antagonists
(administration & dosage)
- Vomiting
(drug therapy, etiology)
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