Abstract |
In a pharmacokinetic study with Humate-P including six patients with various types of von Willebrand disease, a median half-life of 11.3 h for vWF:RCoF and of 15.2 h for vWF:Ag was found. The median value of in vivo recovery (IVR) was estimated for vWF:RCoF as 2.10 IU dL-1 plasma per 1 substituted IU kg-1 b.w. (or 73%), for vWF:Ag as 1.88 IU dL-1 plasma per 1 substituted IU kg-1 b.w. (or 69%); and for FVIII:C as 2.69 IU dL-1 plasma per 1 IU kg-1 b.w. (or 99%). Transient postinfusion shortening or normalization of previously prolonged bleeding time was observed in all patients. In a retrospective study involving 97 patients with various von Willebrand disease types, clinical efficacy and safety of treatment with Haemate-P in 73 surgical interventions, 344 separate bleeding events, 93 other events and 20 cycles of prophylactic treatment were evaluated. The clinical efficacy was rated good to excellent in 99% of the surgeries, in 97% of the bleeding episodes, in 86% of the other events, and in all prophylactic treatments. The overall tolerability was good. Adverse events possibly or probably associated with use of Humate-P/ Haemate-P were rare, of non-serious nature and mild to moderate in their intensity.
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Authors | A Dobrkovska, U Krzensk, J R Chediak |
Journal | Haemophilia : the official journal of the World Federation of Hemophilia
(Haemophilia)
Vol. 4 Suppl 3
Pg. 33-9
( 1998)
ISSN: 1351-8216 [Print] England |
PMID | 10028316
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Factor VIII
(administration & dosage, adverse effects, pharmacokinetics)
- Female
- Humans
- Male
- Middle Aged
- von Willebrand Diseases
(drug therapy)
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