EGF Family of Proteins

A family of proteins that are related to epidermal growth factor. They share in common a consensus sequence consisting of six spatially conserved CYSTEINE residues which form three intramolecular bonds. This consensus sequence is commonly referred to EGF motif and is considered essential for binding of the proteins to ERB RECEPTORS.

Also Known As:

Networked: 90 relevant articles (3 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Herndon, David N: 2 articles (05/2007 - 05/2005)
2.	Jeschke, Marc G: 2 articles (05/2007 - 05/2005)
3.	Chen, Hong-Bo: 1 article (03/2022)
4.	Cheng, Fang: 1 article (03/2022)
5.	Pang, Yu-Xin: 1 article (03/2022)
6.	Su, Dan-Dan: 1 article (03/2022)
7.	Tian, Xin-Hui: 1 article (03/2022)
8.	Wei, Lan: 1 article (03/2022)
9.	Xi, Li-Fang: 1 article (03/2022)
10.	Yang, Cheng: 1 article (03/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "The proposed haptotaxis model combines the macroscopic phenomenon of the invasion of the extracellular matrix by both types of cancer cells with the microscopic dynamics of the epidermal growth factors. " 02/01/2012 - "In most of the patients with the advanced stages of this cancer, the gene for epidermal growth factors receptor (EGFR) is mutated, as the deletion variant III, resulting in the truncated transcripts and products. " 01/01/2003 - "Overexpression of the receptor Her-2 leads to increased proliferative response to epidermal growth factors which plays a key role in tumor development and growth. " 11/01/1987 - "Quantitative differences in the effects of mouse and human epidermal growth factors on A431 human tumor cells." 01/01/2021 - "Human epidermal growth factors play an important role in ovarian carcinogenesis and are evaluated for prognostic and possible therapeutic roles in high-grade serous ovarian malignancies. "
2.	Colorectal Neoplasms (Colorectal Cancer) 12/01/1998 - "The human colon adenocarcinoma-derived cell line Caco-2 was used as a model system to study the interaction of epidermal growth factors (EGF) and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in control of colorectal cancer cell growth. " 03/01/2015 - "We examined the correlation between circulating levels of the epidermal growth factors amphiregulin and transforming growth factor-α (TGF-α) and the MET ligand hepatocyte growth factor and sensitivity to the anti-epidermal growth factor receptor antibody in colorectal cancer (CRC) patients. " 10/14/2014 - "Molecular targeting therapy with bevacizumab against vascular endothelial growth factors (VEGF) and with cetuximab and panitumumab against the epidermal growth factors pathway that have been approved for treating colorectal cancer are not considered effective for treating gastric cancer according to several clinical trials. " 01/01/2003 - "RT-PCR transcripts of EGFR ligands (EGF, TGF-alpha, HB-EGF, and amphiregulin) were detected in both carcinomas and normal mucosa, indicating that autocrine growth stimulation of colorectal carcinomas is mediated by coexpression of EGF receptor ligands and upregulation of EGF receptors. "
3.	Stomach Neoplasms (Stomach Cancer) 10/14/2014 - "Molecular targeting therapy with bevacizumab against vascular endothelial growth factors (VEGF) and with cetuximab and panitumumab against the epidermal growth factors pathway that have been approved for treating colorectal cancer are not considered effective for treating gastric cancer according to several clinical trials. "
4.	Varicose Ulcer (Ulcer, Venous) 02/01/2021 - "Efficacy of Human Recombinant Epidermal Growth Factors vs Conventional Therapy for the Treatment of Chronic Venous Ulcers: A Retrospective Case Series."
5.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 02/01/2015 - "More than even before, the efficacy of epidermal growth factors (EGFRs) tyrosine kinase inhibitors in non-small-cell lung cancer patients carrying EGFR wild-type tumors has been under investigation. "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Cetuximab (Erbitux)
3.	Vascular Endothelial Growth Factors
4.	Panitumumab (Vectibix)
5.	Bevacizumab (Avastin)
6.	Tyrosine Kinase Inhibitors
7.	Epidermal Growth Factor (EGF)
8.	Intercellular Signaling Peptides and Proteins (Growth Factors)
9.	Collagen
10.	Complementary DNA (cDNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Aftercare (After-Treatment)