Vascular Remodeling

The active alterations of vascular wall structures, often leading to elevated VASCULAR RESISTANCE. It is associated with AGING; ATHEROSCLEROSIS; DIABETES MELLITUS; HYPERTENSION; PREGNANCY; PULMONARY HYPERTENSION; and STROKE, but is also a normal part of EMBRYOGENESIS.

Also Known As:

Pulmonary Arterial Remodeling; Arterial Remodeling, Pulmonary; Arterial Remodelings, Pulmonary; Pulmonary Arterial Remodelings; Remodeling, Pulmonary Arterial; Remodeling, Vascular; Remodelings, Pulmonary Arterial; Remodelings, Vascular; Vascular Remodelings

Networked: 4875 relevant articles (258 outcomes, 579 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pulmonary Hypertension
2.	Hypertension (High Blood Pressure)
3.	Hypoxia (Hypoxemia)
4.	Fibrosis (Cirrhosis)
5.	Inflammation (Inflammations)

Experts

1.	Seeger, Werner: 37 articles (01/2022 - 04/2004)
2.	Weissmann, Norbert: 37 articles (02/2021 - 05/2003)
3.	Schiffrin, Ernesto L: 33 articles (01/2022 - 01/2002)
4.	Wang, Jian: 32 articles (01/2022 - 09/2007)
5.	Grimminger, Friedrich: 31 articles (02/2021 - 04/2004)
6.	Stenmark, Kurt R: 30 articles (10/2021 - 12/2005)
7.	Morrell, Nicholas W: 26 articles (01/2019 - 11/2004)
8.	Humbert, Marc: 23 articles (01/2022 - 12/2005)
9.	Yuan, Jason X-J: 22 articles (01/2022 - 09/2002)
10.	Touyz, Rhian M: 22 articles (10/2021 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Vascular Remodeling:

1.	MonocrotalineIBA 11/15/2017 - "Our previous study has shown that FAS inhibition prevented smooth muscle cell proliferation, reversed pulmonary vascular remodeling and improved pulmonary vasoreactivity in monocrotaline induced PH model. " 11/19/2022 - "In vivo, circGSAP overexpression improved survival, and alleviated pulmonary vascular remodeling of monocrotaline-induced PH (MCT-PH) rats. " 01/01/2021 - "In the prolonged reversal protocol, E6446 treatment (days 14-24 after monocrotaline injection) reversed total pulmonary vascular resistance index and vascular remodeling, and improved survival in monocrotaline-exposed rats. " 10/01/2023 - "In this study, monocrotaline-induced PH (MCT-PH) rat model and primarily cultured rat distal pulmonary arterial smooth muscle cells (PASMCs) were used to investigate the mechanisms of ALO on experimental PH, pulmonary vascular remodeling, and excessive proliferation of PASMCs. " 01/01/2019 - "The purposes of this study are to determine the functions of eIF2α and autophagy in the vascular remodeling of the monocrotaline-induced PAH rats and to clarify the correlation between eIF2α and autophagy. "
2.	Sildenafil Citrate (Viagra)FDA Link 10/01/2016 - "Prenatal treatment with sildenafil improved lung morphology and attenuated vascular remodeling with reduced muscularization of the smaller vessels. " 01/01/2023 - "While sildenafil alone partially rescues metabolic alterations associated with PH, treatment with HDACi, in combination with sildenafil, represent a promising and potentially more effective strategy for targeting vasoconstriction, metabolic derangement and pathological vascular remodeling in PH." 01/01/2020 - "Enhancement of embryonic pulmonary blood flow via intra-amniotic sildenafil results in lung growth and attenuation of pulmonary vascular remodeling and may have therapeutic potential for CDH." 01/01/2019 - "Targeted Delivery of Sildenafil for Inhibiting Pulmonary Vascular Remodeling." 11/01/2014 - "In this rat model, antenatal treatment with sildenafil attenuates vascular remodeling. "
3.	Angiotensin IIIBA 01/01/2014 - "Recently, we reported that NO-NIF ameliorates angiotensin II-induced vascular remodeling via antioxidative effects in vivo and in vitro. " 01/01/2018 - "In this study, antisense-CD68 mice were used to study the effect and mechanism of angiotensin II-induced hypertensive vascular remodeling under specific suppression of macrophage CD68. " 01/01/2015 - "This study supports the pivotal role of the CD4(+) T-lymphocytes in angiotensin II-mediated vascular stiffening and that angiotensin II-mediated aortic stiffening is due to the additive effect of active vascular smooth muscle vasoconstriction and vascular remodeling. " 01/01/2015 - "To study the dependence upon lymphocytes in vascular stiffening, we compared an angiotensin II-model of vascular stiffening in normal C57BL/6J mice with lymphocyte-deficient RAG 1(-/-) mice and additionally characterized the component of vascular stiffness due to vasoconstriction vs. vascular remodeling. " 01/01/2013 - "This study was to explore the effect of inhibiting Notch signal on pulmonary vascular remodeling induced by angiotensin II. Vessel strips taken from healthy Wistar rats were cocultured with extrogenous angiotensin II and the potent smooth muscle cell proliferation stimulators for 7 days. "
4.	Vasodilator Agents (Vasodilators)IBA 01/01/2016 - "While currently approved drugs for PAH have some benefits, these vasodilators only have limited efficacy for eliminating pulmonary vascular remodeling and reducing mortality. " 12/27/2021 - "Selective pulmonary vasodilators have improved the prognosis of PAH; however, they are not able to reverse pulmonary vascular remodeling. " 01/01/2023 - "Pulmonary vasodilators were avoided to reduce the negative effects of pulmonary overflow and prevent vascular remodeling. " 03/01/2022 - "The Influence of Topical Vasodilator-Induced Pharmacologic Delay on Cutaneous Flap Viability and Vascular Remodeling." 02/26/2014 - "The reversal of pulmonary vascular remodeling increased the capacity of vasodilators to reduce pulmonary arterial pressure. "
5.	Proteins (Proteins, Gene)FDA Link 01/01/2020 - "Several TRPC subfamily member proteins-especially TRPC1 and TRPC6-are upregulated in pathological VSMCs, and pharmacological inhibition of TRPC channel activity has been reported to improve hypertensive vascular remodeling in rodents. " 10/01/2022 - "The aim of this study was to determine whether reduced expression or inactivation of SIK1 is associated with pulmonary arterial remodeling in PAH and to elucidate whether it is related to the Hippo/Yes-associated protein (YAP) pathway. " 01/01/2022 - "The purpose of this study was to identify proteins that regulate vascular remodeling in an ROP mouse model. " 01/01/2006 - "The study aim was to assess the expression of extracellular matrix (ECM) proteins involved in stress-induced vascular remodeling in the convexity and the concavity of dilated ascending aortas with aortic valve regurgitation. " 03/01/2003 - "In this review, we will discuss recent studies implicating the cell cycle regulatory protein p27Kip1 as a key modulator of vascular cell growth and locomotion in vitro and during vascular remodeling in vivo."
6.	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/01/2018 - "These studies have described a reduction in endothelial cell nitric oxide synthesis, the induction of inflammatory and procoagulant phenotypes, an increase in endothelial proliferation, and impairments in vascular remodeling and angiogenesis. " 01/01/2017 - "The objective of this study is to test whether nitric oxide (NO) regulates ILK in vascular remodeling. " 01/01/2020 - "Endothelial nitric oxide (NO) is a critical mediator of vascular function and vascular remodeling. " 10/15/2017 - "Nitric oxide is an important mediator of pulmonary vascular tone and vascular remodeling. " 01/01/2017 - "In small arteries, ageing shows a eutrophic vascular remodeling and a reduced nitric oxide availability. "
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/06/2010 - "VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling." 04/01/2023 - "Taken together, this study highlights the potential of photopatterned aptamer-tethered VEGF to spatiotemporally regulate vascular morphogenesis as a tool for controlling vascular remodeling in situ." 03/08/2007 - "Several studies have indicated that one of the most potent mediators involved in pulmonary vascular remodeling is vascular endothelial growth factor (VEGF). " 04/01/2005 - "In this study, we investigated mechanisms by which recombinant human vascular endothelial growth factor 165 protects the arterial wall from severe vascular remodeling, including calcification, a newly discovered biologic action of vascular endothelial growth factor. " 10/01/2004 - "In this study, we determined the time course and reversibility of the angiogenesis and vascular remodeling produced by vascular endothelial growth factor (VEGF) in a tet-on inducible transgenic system driven by the CC10 promoter in airway epithelium. "
8.	Losartan (Cozaar)FDA LinkGeneric 08/01/2010 - "To determine the effect of losartan on vascular remodeling and the underlying mechanism in spontaneously hypertensive rats(SHR). " 08/01/2010 - "Losartan attenuates vascular remodeling of the aorta in spontaneously hypertensive rats and the underlying mechanism." 05/15/2010 - "The results suggest that losartan may be therapeutically useful in the chronic smoking-induced pulmonary vascular remodeling and PAH and ACE2 may be involved as part of its mechanism. " 03/15/2017 - "Early treatment with losartan effectively ameliorates hypertension and improves vascular remodeling and function in a prehypertensive rat model." 10/15/2012 - "Losartan delayed disease progression, decreased right ventricular afterload and pulmonary vascular remodeling, and restored right ventricular-arterial coupling in rats with PAH. "
9.	CollagenIBA 05/01/2023 - "This study aimed to determine whether collagen triple helix repeat containing-1 (CTHRC1), which is involved in vascular remodeling and bone formation, can stimulate odontogenic differentiation and angiogenesis when administered to human dental pulp stem cells (hDPSCs). " 12/05/2023 - "In vivo, Lien inhibited Ang Ⅱ-induced abdominal aorta wall thickening, reduced collagen deposition in the ventral aortic vessel, and prevented the occurrence of vascular remodeling by inhibiting MAPK/TGF-β1/Smad2/3 signaling activation. " 01/01/2023 - "We detect upregulated OTUD1 in the vascular endothelium of Ang II-challenged mice and show that OTUD1 deletion attenuates vascular remodeling, collagen deposition, and EndMT. " 07/20/2020 - "Furthermore, vascular remodeling and stronger Masson trichrome staining, together with enhanced immunofluorescence signal for collagen 1 alpha 1 (Col1α1), were observed in aortas from treated animals. " 07/01/2020 - "Vascular remodeling indicators, media thickness, collagen and elastic accumulation in the thoracic aorta, of SHRs-treated CJID were attenuated. "
10.	Antihypertensive Agents (Antihypertensives)IBA 01/01/2022 - "The present study shows that HHC exhibited antihypertensive effects by improving vascular function and ameliorated the development of vascular remodeling. " 09/30/2020 - "Conclusion: Our results suggest that the SG extract exhibited antihypertensive effects, which is relevant to alleviation of vascular dysfunction and vascular remodeling of LHRs. " 03/03/2020 - "In conclusion, regular consumption of BBs may be appropriate as a dietary anti-hypertensive strategy via their positive actions on vascular remodeling and compliance." 01/01/2017 - "Therefore, the reduction of vascular remodeling and the up-regulation of Kallikrein-kinin system contribute, at least in part, to the antihypertensive effect of DHI in SHR." 01/01/2015 - "These data show that PQR could exert its antihypertensive effect through deterioration of the vascular remodeling process. "

Therapies and Procedures

1.	Therapeutics 04/07/2023 - "The conservative group achieved satisfying vascular remodeling (partial, 35%; complete, 59%), making it as safe and effective a treatment as endovascular therapy. " 01/01/2019 - "However, current therapies targeting pulmonary vascular remodeling and RVH remain poorly effective in reversing PAH. " 03/01/2005 - "Taken together, our data suggest that CD8+ T cells contribute to the induction of vascular remodeling in allograft vasculopathy and provide evidence that novel therapies which target CD8+ T cell effector function might be effective in mitigating AV in the clinical setting." 03/01/2009 - "Several of these compounds hold promise for the future therapy of PAH, especially as regression of pulmonary vascular remodeling appears to become a realistic possibility with the combination of established and novel treatments." 12/01/2013 - "However with the improved understanding of the pulmonary vascular remodeling that characterizes the disease, there is optimism that the disconnect between preclinical and clinical studies may be bridged with some of the newer therapies that are now at different stages of clinical evaluation. "
2.	Drug Therapy (Chemotherapy) 07/25/2023 - "Unfortunately, current drug therapies offer limited relief for vascular remodeling. " 10/01/2019 - "Here, we asked whether radiation-induced vascular remodeling translates into improved tissue distribution and efficacy of chemotherapy. " 11/15/2010 - "We describe a mechanism by which a specific, cytotoxic antivascular agent causes vascular remodeling and improved chemotherapy results. " 06/08/2022 - "This warrants the need for drug therapies targeting angiogenesis and vascular remodeling mechanisms. " 05/01/2014 - "The proliferation of pulmonary arterial smooth muscle cells (PASMCs) is a key pathophysiological component of vascular remodeling in pulmonary arterial hypertension (PAH), an intractable disease, for which pharmacotherapy is limited and only slight improvement in survival outcomes have achieved over the past few decades. "
3.	Transplantation 01/01/2022 - "Although scant, recent PH findings and other literature support a role for mitochondrial transplantation as a therapeutic approach in the context of PH. In experimental models of PH, it confers beneficial effects that include reduced pulmonary vasoconstriction, reduced pulmonary vascular remodeling, and improved right ventricular function. " 01/01/2022 - "The animals were sacrificed at 1, 3 and 5 weeks after transplantation and vascular remodeling and follicular development were analyzed. " 12/01/2019 - "Remarkably, the ameliorated vascular remodeling was recapitulated in WT mice after receiving transplantation of bone marrow (BM) from Sam68-/- mice, suggesting the effect was attributable to BM-derived inflammatory cells. " 10/01/2019 - "Transplantation of cultured PV-ADSCs in mouse vein graft model suggested the contribution of PV-ADSCs to vascular remodeling through smooth muscle differentiation. " 10/01/2018 - "The rat model of aortic transplantation was established to detect PI3Kγ expression and its role in neointimal formation and vascular remodeling in vivo. "
4.	Stents 10/28/2022 - "The results from this study can be used to guide surgical planning and future ENI designs; stent oversizing parameters to blood vessel diameter should be considered to minimize detrimental vascular remodeling." 08/01/2004 - "The aim of the study was to characterize the vascular lesions and repair processes within the first 4 weeks after implantation of oversized stents in the rabbit carotid artery and thereby contribute to the understanding of vascular remodeling during stent implantation. " 03/01/2004 - "Intravascular ultrasound study of the effect of beta-emitting ((55)Co) stents on vascular remodeling and intimal proliferation." 07/01/2002 - "Later stents were proven to reduce the restenosis rate of PCI from 30%-40% with balloon angioplasty to 15%-20% with stents, primarily by eliminating elastic recoil and vascular remodeling as shown by intravascular ultrasound (IVUS) studies. " 01/01/1998 - "IVUS studies have confirmed vascular remodeling in vivo, have proposed a high-pressure stent implantation strategy and have shown two key mechanisms of restenosis after angioplasty: plaque proliferation and vessel shrinkage (negative remodeling). "
5.	Vagus Nerve Stimulation 10/01/2022 - "Vagal nerve stimulation (VNS) ameliorates pulmonary vascular remodeling and improves survival in a rat model of pulmonary hypertension (PH). " 10/01/2018 - "Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension."