ErbB-4 Receptor

A cell surface protein-tyrosine kinase receptor that has specificity for EPIREGULIN; BETACELLIN; NEUREGULINS; and HEPARIN-BINDING EGF-LIKE GROWTH-FACTOR.

Also Known As:

Receptor, ErbB-4; HER-4 Proto-oncogene Protein; Proto-oncogene Protein HER-4; Receptor Protein-tyrosine Kinase ErbB-4; Receptor Tyrosine-protein Kinase ErbB-4; c-ErbB-4 Protein; v-erb-a Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian) Protein; ErbB 4 Receptor; HER 4 Proto oncogene Protein; HER-4, Proto-oncogene Protein; Protein HER-4, Proto-oncogene; Protein, HER-4 Proto-oncogene; Proto oncogene Protein HER 4; Proto-oncogene Protein, HER-4; Receptor Protein tyrosine Kinase ErbB 4; Receptor Tyrosine protein Kinase ErbB 4; c ErbB 4 Protein

Networked: 14 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Inbar, Moshe: 2 articles (07/2006 - 09/2003)
2.	Chowdhury, Nabilah I: 1 article (01/2019)
3.	Kennedy, James L: 1 article (01/2019)
4.	Lieberman, Jeffrey A: 1 article (01/2019)
5.	Meltzer, Herbert Y: 1 article (01/2019)
6.	Müller, Daniel J: 1 article (01/2019)
7.	Potkin, Steven G: 1 article (01/2019)
8.	Remington, Gary: 1 article (01/2019)
9.	Tiwari, Arun K: 1 article (01/2019)
10.	Voineskos, Aristotle N: 1 article (01/2019)

Related Diseases

1.	Sarcoma (Soft Tissue Sarcoma) 09/01/2003 - "The aim of this study was to investigate the expression and the prognostic value of the newly described erbB-4 receptor in specimens from adults with bone sarcomas treated by pre- and postoperative chemotherapy. "
2.	Tardive Dyskinesia 01/01/2019 - "Genetic study of neuregulin 1 and receptor tyrosine-protein kinase erbB-4 in tardive dyskinesia."
3.	Neoplasms (Cancer) 07/01/1998 - "The pattern of c-erbB-4 protein expression is also reported in a survey of common solid human cancers. " 04/01/1996 - "This domain provides recognition specificity for ErbB-3 and ErbB-4 receptor expressing tumor cells. " 09/01/1998 - "We also demonstrate NRG1-beta expression in 87% (n = 46 of 48) of medulloblastoma primary tumors, with the greatest expression levels occurring in tumors with high ErbB-2 and ErbB-4 receptor coexpression. "
4.	Breast Neoplasms (Breast Cancer) 07/01/2001 - "The expression of c-erbB-4 in the node negative group was, however, associated with a better prognosis, indicating a different role of c-erbB-4 protein in breast tumor development than other EGFR family members have. " 03/01/2000 - "c-erbB-4 protein expression in human breast cancer." 10/15/1999 - "Our data suggest that elevation of the ErbB-4 receptor plays a role in ER+ breast cancer cell proliferation. " 10/15/1999 - "These results provide a better understanding of the biological significance of ErbB-4 receptor in breast cancer. " 10/15/1999 - "ErbB-4 receptor expression appeared to correlate with ER+ primary breast tumors. "
5.	Serous Cystadenocarcinoma 05/01/1998 - "A total of 17 serous cystadenocarcinomas were analyzed for epidermal growth factor receptor (EGF-R or ErbB-1) and ErbB-2, ErbB-3, and ErbB-4 receptor expression by Western blot analysis. "

Related Drugs and Biologics

1.	Neuregulin-1 (Neuregulin 1)
2.	ErbB Receptors (EGF Receptor)
3.	Neuregulins
4.	Messenger RNA (mRNA)
5.	Protein-Tyrosine Kinases (Tyrosine Kinase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)