ErbB Receptors (EGF Receptor)

A family of structurally related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. The receptors are activated upon binding of specific ligands which include EPIDERMAL GROWTH FACTORS, and NEUREGULINS.

Also Known As:

EGF Receptor; EGF Receptors; Epidermal Growth Factor Receptor Family Proteins; Epidermal Growth Factor Receptor Kinase; HER Family Receptors; Proto-oncogene c-ErbB-1 Protein; Receptor Tyrosine-protein Kinase erbB-1; Receptor, ErbB-1; Receptors, Epidermal Growth Factor; Epidermal Growth Factor Receptor Protein Tyrosine Kinase; ErbB-1 Receptor; Family Receptor, HER; Family Receptors, HER; Proto oncogene c ErbB 1 Protein; Proto-Oncogene Protein, erbB-1; Receptor Tyrosine protein Kinase erbB 1; Receptor, ErbB; Receptor, ErbB 1; Receptor, HER Family; Receptor, TGF alpha; Receptor, Transforming Growth Factor alpha; Receptors, EGF; Receptors, Epidermal Growth Factor Urogastrone; Receptors, ErbB; Receptors, HER Family; c erbB 1 Protein; c-ErbB-1 Protein, Proto-oncogene; erbB 1 Proto Oncogene Protein; Epidermal Growth Factor Receptor; Epidermal Growth Factor Receptor Family Protein; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; ErbB Receptor; HER Family Receptor; Receptor, EGF; Receptor, Epidermal Growth Factor; Receptor, TGF-alpha; Receptor, Transforming-Growth Factor alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; TGF-alpha Receptor; Transforming Growth Factor alpha Receptor; Urogastrone Receptor; c-erbB-1 Protein; erbB-1 Proto-Oncogene Protein

Networked: 27986 relevant articles (1769 outcomes, 3421 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhang, Li: 113 articles (01/2022 - 11/2002)
2.	Jänne, Pasi A: 99 articles (01/2022 - 09/2002)
3.	Mitsudomi, Tetsuya: 95 articles (09/2022 - 12/2004)
4.	Wu, Yi-Long: 91 articles (11/2022 - 01/2006)
5.	Kiura, Katsuyuki: 90 articles (08/2022 - 01/2004)
6.	Ciardiello, Fortunato: 88 articles (03/2022 - 06/2002)
7.	Nakagawa, Kazuhiko: 81 articles (09/2022 - 06/2003)
8.	Rosell, Rafael: 79 articles (01/2022 - 03/2004)
9.	Park, Keunchil: 78 articles (01/2022 - 04/2007)
10.	Shih, Jin-Yuan: 77 articles (01/2022 - 02/2006)

Related Diseases

1.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 08/11/2015 - "Targeting these driver mutations, such as sensitizing epidermal growth factor receptor (EGFR) mutations, has dramatically improved the prognosis of advanced non-small cell lung cancer (NSCLC). " 01/01/2019 - "It remains unknown which is the optimal first-line treatment regimen for patients with advanced epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). " 01/01/2019 - "Treatment of non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) activating mutation with EGFR-TKIs has achieved great success, yet faces the development of acquired resistance as the major obstacle to long-term disease remission in the clinic. " 01/01/2017 - "Targeting epidermal growth factor receptor (EGFR) in patients with non-small-cell lung cancer (NSCLC) having EGFR mutations is associated with an improved overall survival. " 01/01/2020 - "Several preclinical studies suggested a potential benefit from combined treatment with inhibitors of epidermal growth factor receptor (EGFR) and angiogenesis, both effective in patients with advanced non-small-cell lung cancer (NSCLC). "
2.	Neoplasms (Cancer) 04/01/2014 - "Most SCAC tumors overexpress epidermal growth factor receptor (EGFR); therefore, it is reasonable to consider anti-EGFR drugs as a new treatment option, as demonstrated by anecdotal reports. " 02/01/2009 - "ERBB receptor inhibitors are very effective against specific primary tumors and their use is frequently accompanied by toxicity problems, drug resistance and molecular desensitization. " 09/09/2023 - "The present review explores the potential of targeted epidermal growth factor receptor (EGFR) nanotherapy as an alternative treatment for NSCLC, showing that EGFR-targeted nanoparticles are efficiently taken up by NSCLC cells, leading to a significant reduction in tumor growth in mouse models. " 01/01/2021 - "Targeting epidermal growth factor receptor (EGFR) has significantly improved the clinical outcome in many cancers. " 10/05/2020 - "The transfection agent is successfully applied to deliver siRNAs targeting endogenous genes of epidermal growth factor receptor (EGFR) and kinesin-5 (Eg5) to cancer cells, showing good results on Eg5 and EGFR silencing ability and inhibition of cancer cell migration. "
3.	Breast Neoplasms (Breast Cancer) 12/22/2015 - "Blockade of human epidermal growth factor receptor type 2 (HER2) has dramatically improved outcome for patients with HER2-positive breast cancer. " 05/10/2014 - "The highly effective treatment of human epidermal growth factor receptor (HER) 2-amplified breast cancer has proven challenging because of a signal buffering capacity inherent in the functionally relevant HER2-HER3 target. " 02/01/2014 - "To review the most recent developments in the treatment of human epidermal growth factor receptor type 2 (HER2)-positive breast cancer with novel HER2-targeting agents and combinations that have significantly improved clinical outcomes. " 01/01/2018 - "Though advanced and metastatic epidermal growth factor receptor 2 (HER2)-positive disease is not curable, a small proportion of patients with HER2-positive metastatic breast cancer remain in prolonged complete remission with anti-HER2 treatment. " 01/14/2019 - "A better understanding of the GPER, its role in breast cancer, and the interactions with the ER and epidermal growth factor receptor will be beneficial for the disease management and prevention in the future."
4.	Colorectal Neoplasms (Colorectal Cancer) 05/16/2020 - ": Background: The optimal anti-angiogenic strategy as second-line treatment in RAS wild-type metastatic colorectal cancer (mCRC) treated with anti-EGFR (Epidermal Growth Factor Receptor) based first-line treatment is still debated. " 10/21/2019 - "Anti-epidermal growth factor receptor (EGFR) antibody is widely used for the treatment of patients with metastatic colorectal cancer. " 01/01/2018 - "It remains unknown whether blockade of c-Met signaling and epidermal growth factor receptor signaling is effective in suppressing the growth of human colorectal cancer (CRC) cells. " 01/22/2015 - "The epidermal growth factor receptor (EGFR) antibody drugs are effective in a subset of colorectal cancers, but the molecular mechanisms of resistance are understood poorly. " 11/01/2008 - "Novel therapeutic agents targeting the epidermal growth factor receptor (EGFR) have improved outcomes for patients with colorectal carcinoma. "
5.	Lung Neoplasms (Lung Cancer) 08/29/2023 - "However, while epidermal growth factor receptor (EGFR) is an important parameter for lung cancer, EGFR inhibitors also show great promise in the treatment of the disease. " 07/15/2006 - "Inhibitors targeting the epidermal growth factor receptor (EGFR) are effective in a subset of non-small cell lung cancers. " 11/01/2007 - "Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies." 09/01/2019 - "Clinical experience of chinese herbal medicine ameliorates dermatologic events from epidermal growth factor receptor inhibitors for lung cancer: A case series." 01/01/2019 - "Testing for epidermal growth factor receptor mutation for non-squamous cell lung cancer improved from 77% to 100%. "

Related Drugs and Biologics

1.	Tyrosine Kinase Inhibitors
2.	Gefitinib (Iressa)
3.	Erlotinib Hydrochloride (CP 358,774)
4.	Monoclonal Antibodies
5.	osimertinib
6.	Cetuximab (Erbitux)
7.	Afatinib
8.	Hormones (Hormone)
9.	Trastuzumab (Herceptin)
10.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Radiotherapy
4.	Immunotherapy
5.	Molecular Targeted Therapy