Pectus Carinatum

A developmental anomaly characterized by abnormal anterior protrusion of the STERNUM and adjacent COSTAL CARTILAGE.

Also Known As:

Currarino-Silverman Syndrome; Pectus Carinatum, Arcuate; Pectus Carinatum, Chondrogladiolar; Pectus Carinatum, Chondromanubrial; Pouter Pigeon Breast; Arcuate Pectus Carinatum; Arcuate Pectus Carinatums; Breast, Pouter Pigeon; Breasts, Pouter Pigeon; Carinatum, Arcuate Pectus; Carinatum, Chondrogladiolar Pectus; Carinatum, Chondromanubrial Pectus; Carinatum, Pectus; Carinatums, Arcuate Pectus; Carinatums, Chondrogladiolar Pectus; Carinatums, Chondromanubrial Pectus; Carinatums, Pectus; Chondrogladiolar Pectus Carinatum; Chondrogladiolar Pectus Carinatums; Chondromanubrial Pectus Carinatum; Chondromanubrial Pectus Carinatums; Currarino Silverman Syndrome; Pectus Carinatums; Pectus Carinatums, Arcuate; Pectus Carinatums, Chondrogladiolar; Pectus Carinatums, Chondromanubrial; Pigeon Breast, Pouter; Pigeon Breasts, Pouter; Pouter Pigeon Breasts; Syndrome, Currarino-Silverman

Networked: 95 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Congenital Abnormalities (Deformity)
2.	Funnel Chest (Pectus Excavatum)
3.	Scoliosis
4.	Aneurysm (Aneurysms)
5.	Pneumothorax

Experts

1.	Lee, Sungsoo: 4 articles (01/2019 - 12/2012)
2.	de Beer, Sjoerd A: 4 articles (01/2019 - 01/2013)
3.	de Jong, Justin R: 4 articles (01/2019 - 01/2013)
4.	Lee, Seock Yeol: 3 articles (11/2020 - 07/2008)
5.	Lee, Seung Jin: 3 articles (11/2020 - 07/2008)
6.	Del Frari, Barbara: 3 articles (01/2018 - 06/2011)
7.	Schwabegger, Anton H: 3 articles (01/2018 - 06/2011)
8.	Orrick, Beth A: 2 articles (08/2022 - 01/2019)
9.	Pierce, Amy L: 2 articles (08/2022 - 01/2019)
10.	Ermerak, Nezih Onur: 2 articles (04/2021 - 01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pectus Carinatum:

1.	Stainless Steel (Steel, Stainless)IBA 07/01/2016 - "The traditional method for fixing the sternum during surgical repair of pectus carinatum is through the use of a stainless steel bar (Adkin’s strut). " 10/01/1999 - "We evaluate our 14 year single center experience of pectus carinatum correction on 111 patients using a uniform technique of internal stabilization employing stainless steel struts. "
2.	Polypropylenes (Polypropylene)IBA 03/01/1984 - "The other patient had a coexistent pectus carinatum defect, which was repaired by resection of the costal cartilages and osteotomy of the sternum without use of Marlex. " 07/01/1979 - "Type II (pouter pigeon breast) is handled by double transverse osteotomy, chiseling off the protuberant portion of the strernomanuberial junction, and by supporting the lower sternal body with either the suspended xiphoid process or with Marlex mesh. "
3.	Human Growth Hormone (Saizen)FDA LinkGeneric 08/25/2021 - "Among them, 7 patients with height lower than two standard deviations of the mean (or below the third percentile) were treated with recombinant human growth hormone (rhGH), and were followed up every The clinical characteristics were as following: facial anomalies (=12), short stature (=11), congenital heart diseases (=5), facial freckles (=4), coffee spots on the skin (=3), intelligence disability (=3),cryptorchidism (=3), feeding difficulties (=2), scoliosis (=2), pectus carinatum (=2), pectus excavatum (=1), rib dysplasia companied with short finger (=1), hyperopia (=1), myopia (=1) and early puberty (=1). "
4.	Intravenous Immunoglobulins (IVIG)FDA Link 12/15/2022 - "We present two patients with pathogenic ADNP variants and unusual cardiothoracic manifestations-Bland-White-Garland syndrome, pectus carinatum superiorly along the costochondral junctions and pectus excavatum inferiorly in one patient, and Kawasaki syndrome with pericardiac effusion, coronary artery dilatation and aneurysm in the other-who were successfully treated with intravenous immunoglobulin, corticosteroid and aspirin. "
5.	TitaniumIBA 12/01/2010 - "Correction of a severe pouter pigeon breast by triple sternal osteotomy with a novel titanium rib bridge fixation."
6.	Silver Sulfadiazine (SSD)FDA LinkGeneric 04/01/2011 - "Point biserial correlation coefficient analysis (R(pb)) displayed significance for SSD usefulness in patients with previous chest repair surgery (R(pb) = 0.48, P ≤ .001), AATD (R(pb) = 0.34, P = .001), pectus carinatum (R(pb) = 0.27, P = .008), and females (R(pb) = 0.19, P = .044). "
7.	Penicillamine (Cuprimine)FDA Link 01/01/1979 - "Flat feet, scoliosis, pectus carinatum, hypermobility of joints, molluscoid pseudotumors and atrophic scars were alarming side effects of D-penicillamine. "
8.	NucleotidesIBA 06/01/2015 - "Identification of additional patients with single-nucleotide mutations in MARS2 is necessary to determine if pectus carinatum is also a consistent feature of this syndrome."
9.	MetalsIBA 01/01/2014 - "The effects and complications of the minimally invasive extrathoracic presternal compression using a metal bar for correction of pectus carinatum were reviewed. " 01/01/2014 - "This report presents early results of surgical experience of minimal invasive extrathoracic presternal compression using a metal bar for correction of the pectus carinatum. " 01/01/2014 - "Minimal invasive extrathoracic presternal compression using a metal bar for correction of pectus carinatum." 01/01/2014 - "From February 2008 to February 2012, 15 patients with combined pectus carinatum and pectus excavatum underwent minimal invasive extrathoracic presternal compression using a metal bar for correction of pectus carinatum and Nuss operation for pectus excavatum. "
10.	EnzymesIBA 01/01/2021 - "Both children were characterized by the presence of pectus carinatum, kyphoscoliosis, nocturnal enuresis, urinary incontinence, normal intelligence, and loss of strength in the legs, diagnosed as neurogenic bladder in association with MPS IVA through the analysis of the clinical characteristics, enzyme activity and genetic testing. "

Therapies and Procedures

1.	Braces 06/01/2017 - "Dynamic brace compression is a novel treatment for patients with pectus carinatum. " 07/01/2008 - "This study demonstrated that non-surgical treatment using a compressive brace in patients with pectus carinatum was effective, especially in children and teenagers. " 01/01/2023 - "The statistical models predict general trends in pectus carinatum brace treatment and can assist in creating treatment plans, motivating patient compliance, and can inform the design of future treatment systems." 08/01/2022 - "Changes in self-image after pectus carinatum brace treatment." 09/24/2020 - "The correction of chest wall anomalies offers patients significant improvements in quality of life and it should never be regarded as an entirely cosmetic issue. Most patients with pectus carinatum can be corrected with a brace. "
2.	Thoracoplasty 01/01/2018 - "The frequency of thoracoplasties in cases of pectus carinatum (PC) has increased due to improved experience and modified surgical techniques, resulting in low morbidity and low complication rates. " 01/01/2018 - "Ravitsh procedure with the use of device for pectus carinatum repair of our design; main group - 24 (51.06%) patients where our method of thoracoplasty based on changes of deformed ribs biomechanics was used. " 01/01/2018 - "The effect on cardiopulmonary function after thoracoplasty in pectus carinatum: a systematic literature review." 04/15/2014 - "[Compressive anterior thoracoplasty (modified Abramson's repair) for pectus carinatum repair]." 01/01/2011 - "[Thoracoplasty by pectus carinatum in children]."
3.	General Anesthesia 07/01/2008 - "Non-surgical treatment using a compressive brace in patients with pectus carinatum would be helpful for those who dislike surgery because of their fear about general anesthesia and operative complications. "
4.	Therapeutics 08/01/2008 - "We suggest that patients with pectus carinatum have a trial of compression therapy before recommending surgical resection. " 08/01/2023 - "Dynamic Compression Therapy for Pectus Carinatum in Children and Adolescents: Factors for Success." 11/01/2020 - "We performed the doubly double bar technique for ten patients who did not adapt to bracing therapy for patients with pectus carinatum and/or carinatum/excavatum complex type. " 11/01/2020 - "Surgical correction is needed for patients with pectus carinatum who do not adapt to bracing therapy. " 04/20/2017 - "Bracing therapy with static compression system is the treatment of choice for chondrogladiolar pectus carinatum in our unit, because of its effectiveness and lower price. "
5.	Orthotic Devices (Orthosis) 04/01/2021 - "A Comparative Study on Short-Term Effects of Compression Orthosis and Exercises in the Treatment of Pectus Carinatum: A Randomized Controlled Pilot Feasibility Trial." 06/01/2023 - "The Pectus Carinatum Evaluation Questionnaire (PCEQ) was developed for use in patients with pectus carinatum (PC) treated with compression orthosis. " 06/01/2023 - "Psychometric properties of the Turkish version of the Pectus Carinatum Evaluation Questionnaire used in patients with pectus carinatum treated with compression orthosis." 08/01/2000 - "Preliminary results indicate a potential role for compressive orthosis in the management of pectus carinatum. " 08/01/2006 - "Of the patients who received orthoses, 738 had a minimum follow-up of 1 year and 17 of these, 2 with pectus excavatum and 15 with pectus carinatum, presented overcorrection and were studied. "