Voriconazole (Vfend)

03/01/2010 - "The patient showed remarkable improvement with voriconazole suggesting aspergillosis. "
02/01/2004 - "Voriconazole currently offers the best prospect for success and tolerance as a first-line treatment for aspergillosis. "
09/01/2020 - "Voriconazole (VCZ) is currently the first-line treatment for invasive aspergillosis, although the doses are limited by its poor solubility and high hepatic toxicity. "
09/01/2008 - "Clinical application of voriconazole for the treatment of aspergillosis in birds appears to be promising, because this drug has a high effectiveness and wide tissue distribution, and long-term treatment did not cause clinical signs of adverse effects or organ damage in chickens."
10/01/2007 - "Invasive tracheal aspergillosis treated successfully with voriconazole: clinical report and review of the literature."

05/01/2015 - "nidulans infections could be treated effectively with the standard dosage regimen; for extensive metabolizers (EM), the standard voriconazole dosage regimen failed to achieve the best outcome for the six Aspergillus spp. Increasing dose (e.g. "
06/01/2020 - "The prompt identification of the fungus and administration of oral Voriconazole resolved the skin infection with complete remission."
01/01/2011 - "Given its good CNS penetration, voriconazole along with surgical resection appears to be promising in treatment of these infections. "
11/01/2004 - "Fusarium dimerum infection in a stem cell transplant recipient treated successfully with voriconazole."
02/01/2015 - "Intrastromal voriconazole helped to resolve the infection in 18 (72%) patients and about 15% of these needed more than one injection. "

09/11/2016 - "Topical application of voriconazole is on effective method for the freatment of fungal keratitis Topical voriconazole is highly effective for fungal keratitis caused by Alternaria spp. and Aspergillus, however, for Fusarium, it is relatively low effective. "
01/01/2017 - "The keratitis was significantly improved after voriconazole. "
01/01/2022 - "Voriconazole combined with CXL is effective in treating Aspergillus-infected keratitis. "
09/11/2016 - "[Topical voriconazole as an effective treatment for fungal keratitis]."
07/01/2015 - "Voriconazole spreads well in the eye and is effective in the cure of fungal keratitis including those caused by Alternaria."

02/26/2013 - "Voriconazole therapeutic drug levels were not associated with improvement in clinical outcomes among patients with proven or probable invasive fungal disease. "
09/01/2007 - "Seventy-one allograft recipients receiving voriconazole, in whom complete clinical, microbiologic and pharmacokinetic data were available, were studied to determine the efficacy of voriconazole in preventing fungal infections. "
02/24/2014 - "More patients died in the voriconazole group and a claimed significant reduction in the number of breakthrough fungal infections disappeared when patients arbitrarily excluded from the analysis by the trial authors were included. "
01/01/2012 - "Given high index of suspicion for fungal disease in an immunocompromised host, empiric antifungals were discontinued and voriconazole initiation resulted in a successful therapy. "
01/25/2006 - "More patients died in the voriconazole group and a claimed significant reduction in the number of breakthrough fungal infections disappeared when patients arbitrarily excluded from analysis by the authors were included. "

08/01/2012 - "Challenging recommended oral and intravenous voriconazole doses for improved efficacy and safety: population pharmacokinetics-based analysis of adult patients with invasive fungal infections."
10/01/2012 - "The effect of therapeutic drug monitoring on safety and efficacy of voriconazole in invasive fungal infections: a randomized controlled trial."
05/01/2003 - "Voriconazole is an effective and well-tolerated treatment for refractory or less-common invasive fungal infections."
04/01/2013 - "There are increasing insights into voriconazole concentrations that are safe and effective for treatment of invasive fungal infections. "
11/01/2023 - "Current study aims to explore the correlation between the administered dose and efficacy of voriconazole in the treatment of invasive fungal infection (IFI). "