Cytochrome P-450 CYP1B1

A cytochrome P450 aryl hydrocarbon hydroxylase that has specificity for ESTROGENS which it converts into 4-hydroxy estrogens. CYP1B1 has been shown to be physiologically important for FETAL DEVELOPMENT with mutations in the CYP1B1 gene resulting in congenital forms of GLAUCOMA and Peter's anomaly.

Also Known As:

Networked: 68 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dada, Rima: 4 articles (08/2010 - 06/2009)
2.	Dada, Tanuj: 4 articles (08/2010 - 06/2009)
3.	Tanwar, Mukesh: 4 articles (08/2010 - 06/2009)
4.	Sihota, Ramanjit: 3 articles (08/2010 - 06/2009)
5.	Bejjani, Bassem A: 3 articles (04/2006 - 09/2002)
6.	Melvin, W T: 3 articles (08/2004 - 07/2001)
7.	Murray, G I: 3 articles (08/2004 - 07/2001)
8.	Mashima, Y: 3 articles (03/2003 - 09/2000)
9.	Miyata, H: 3 articles (03/2003 - 09/2000)
10.	Ohtake, Y: 3 articles (03/2003 - 09/2000)

Related Diseases

1.	Glaucoma 11/03/2021 - "This study aims to report the developmental and histopathological features of ocular tissues from an electively aborted human fetus with mutations in cytochrome p4501B1, and thus predisposed to primary congenital glaucoma in comparison to an age-matched healthy fetal globe. " 01/01/2010 - "Mutations in the cytochrome P4501B1 (CYP1B1) gene have been reported to be associated with primary congenital glaucoma and other forms of glaucoma and mutations in pituitary homeobox 2 (PITX2) gene have been identified in ARS in various studies. " 07/08/2009 - "To screen cytochrome P4501B1 (CYP1B1) for causative mutations in Omani patients with a clinical diagnosis of primary congenital glaucoma (PCG) METHODS: Nine PCG families were recruited for the study. " 03/01/2023 - "Investigation of mutational spectrum in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma." 11/03/2021 - "We also describe histopathological changes in the primary congenital glaucoma-affected globes revealing the effect of cytochrome p4501B1 deficiency on ocular tissues during early fetal development contributing to the glaucoma phenotype."
2.	Breast Neoplasms (Breast Cancer) 02/12/2010 - "Studies investigating possible associations between cytochrome P4501B1 (CYP1B1) polymorphisms and breast cancer risk have been inconsistent. " 08/26/2022 - "Cytochrome P4501B1 (CYP1B1) is elevated in breast cancer. " 10/30/1995 - "Expression of cytochrome P450 CYP1B1 in breast cancer." 11/01/2002 - "Cytochrome P450 CYP1B1 and catechol O-methyltransferase (COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population." 11/01/1999 - "Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1."
3.	Neoplasms (Cancer) 01/01/2023 - "Cytochrome P4501B1 (CYP1B1) is reported to be overexpressed in various malignancies including ovarian, lung, lymph, and breast cancers. " 03/01/2009 - "Nutrition and the prevention and treatment of cancer: association of cytochrome P450 CYP1B1 with the role of fruit and fruit extracts." 12/01/2003 - "It has been shown that cytochrome P4501B1 (CYP1B1) is over-expressed in variety of tumors. " 07/15/1997 - "Tumor-specific expression of cytochrome P450 CYP1B1." 10/01/2022 - "Cytochrome P4501B1 is a ubiquitous family protein that is majorly overexpressed in tumors and is responsible for biotransformation-based inactivation of anti-cancer drugs. "
4.	Angle-Closure Glaucoma (Glaucoma, Angle Closure) 03/01/2013 - "Recently, several studies have investigated genetic associations between Cytochrome P450 (CYP1B1), Endothelial nitric oxide synthase (eNOS), and Neurotrophin-4 (NTF4) with primary angle-closure glaucoma (PACG) in various ethnic groups. "
5.	Intrahepatic Cholestasis of Pregnancy 05/01/2008 - "To study the role of gene polymorphisms of cytochrome P4501B1 (CYP1B1) in exon 2 codon 119(G-T) and exon 3 codon 432(C-G) in intrahepatic cholestasis of pregnancy (ICP). "

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