Sepsis-Associated Encephalopathy

Acute neurological dysfunction during severe SEPSIS in the absence of direct brain infection characterized by systemic inflammation and BLOOD BRAIN BARRIER perturbation.

Also Known As:

Sepsis Associated Delirium; Sepsis Associated Encephalopathy; Sepsis-Associated Delirium; Associated Delirium, Sepsis; Associated Deliriums, Sepsis; Associated Encephalopathies, Sepsis; Associated Encephalopathy, Sepsis; Delirium, Sepsis Associated; Delirium, Sepsis-Associated; Deliriums, Sepsis Associated; Deliriums, Sepsis-Associated; Encephalopathies, Sepsis Associated; Encephalopathies, Sepsis-Associated; Encephalopathy, Sepsis Associated; Encephalopathy, Sepsis-Associated; Sepsis Associated Deliriums; Sepsis Associated Encephalopathies; Sepsis-Associated Deliriums; Sepsis-Associated Encephalopathies

Networked: 198 relevant articles (17 outcomes, 26 trials/studies)

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 14178
- Central Nervous System Diseases: 4213
  - Brain Diseases: 15694
    - Sepsis-Associated Encephalopathy: 198

Related Diseases

1.	Sepsis (Septicemia)
2.	Cognitive Dysfunction
3.	Neuroinflammatory Diseases
4.	Lung Injury
5.	Inflammation (Inflammations)

Experts

1.	Huang, Li: 7 articles (07/2021 - 03/2012)
2.	Bao, Hongguang: 6 articles (01/2022 - 11/2017)
3.	Si, Yanna: 6 articles (01/2022 - 11/2017)
4.	Zhang, Yuan: 5 articles (10/2022 - 01/2020)
5.	Chen, Hongguang: 5 articles (01/2022 - 11/2014)
6.	Yu, Yonghao: 5 articles (01/2022 - 11/2014)
7.	Xie, Keliang: 5 articles (06/2021 - 11/2014)
8.	Ji, Mu-Huo: 5 articles (12/2019 - 04/2017)
9.	Yang, Jian-Jun: 5 articles (12/2019 - 04/2017)
10.	Qu, Yi: 4 articles (06/2022 - 06/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sepsis-Associated Encephalopathy:

1.	Proteins (Proteins, Gene)FDA Link 01/01/2021 - "These results helped to understand the role of S100B protein in the pathophysiology of sepsis-associated encephalopathy and could be helpful to further experimental studies regarding this subject." 11/01/2023 - "To investigate the role and underlying mechanism of human myeloid differentiation protein 2 (MD2) in the process of neuronal death induced by lipopolysaccharide (LPS) by establishing an in vitro model of sepsis-associated encephalopathy (SAE) by LPS. " 01/01/2020 - "The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome has been identified as an important mediator of blood-brain-barrier disruption in sepsis-associated encephalopathy (SAE). " 10/01/2017 - "Objective: To investigate the diagnostic value of neuron-specific enolase(NSE), central nervous system specific protein(S100β), interleukin-6(IL-6) in sepsis-associated encephalopathy(SAE). " 11/01/2021 - "Our study results revealed that the expression levels of PICK1 protein in mice with lipopolysaccharide-induced sepsis-associated encephalopathy were not significantly changed, but PICK1 deficiency led to excessive activation of microglia and Toll-like receptor (TLR)4 pathways, which aggravated the sepsis- associated encephalopathy. "
2.	Brain Natriuretic Peptide (Natrecor)FDA Link 04/01/2020 - "This study aimed to explore whether Recombinant human brain natriuretic peptide (rhBNP) has protective effects against sepsis-associated encephalopathy (SAE) in a mouse model. " 04/01/2020 - "Therapeutic effects of recombinant human brain natriuretic peptide on sepsis-associated encephalopathy in mice." 01/01/2023 - "Corrigendum: Interferon-induced transmembrane protein 3 in the hippocampus: a potential novel target for the therapeutic effects of recombinant human brain natriuretic peptide on sepsis-associated encephalopathy." 01/01/2023 - "Interferon-induced transmembrane protein 3 in the hippocampus: a potential novel target for the therapeutic effects of recombinant human brain natriuretic peptide on sepsis-associated encephalopathy."
3.	DexpramipexoleIBA 01/01/2023 - "Dexpramipexole ameliorates cognitive deficits in sepsis-associated encephalopathy through suppressing mitochondria-mediated pyroptosis and apoptosis." 01/01/2023 - "This study was aimed at evaluating the effects of dexpramipexole (DPX) - a mitochondrial protectant that sustains mitochondrial function and energy production - on cognitive function in a mouse model of sepsis-associated encephalopathy (SAE) induced by peripheral administration of lipopolysaccharide (LPS) and examining the potential mechanisms. "
4.	HydrogenIBA 11/04/2014 - "To evaluate protective effects of inhaled hydrogen gas (H2) on cognitive function in a murine model of sepsis-associated encephalopathy (SAE). " 11/04/2014 - "[Protective effects of inhaled hydrogen gas on cognitive function in mice with sepsis-associated encephalopathy]." 05/01/2023 - "Hydrogen regulates mitochondrial quality to protect glial cells and alleviates sepsis-associated encephalopathy by Nrf2/YY1 complex promoting HO-1 expression." 01/01/2023 - "Hydrogen (H2) can protect against blood‒brain barrier (BBB) damage in sepsis-associated encephalopathy (SAE), but the mechanism is still unclear. " 01/01/2023 - "Effect of molecular hydrogen treatment on Sepsis-Associated encephalopathy in mice based on gut microbiota."
5.	InflammasomesIBA 02/01/2023 - "Microglial NLRP3 Inflammasome Induces Excitatory Synaptic Loss Through IL-1β-Enriched Microvesicle Release: Implications for Sepsis-Associated Encephalopathy." 01/01/2023 - "SS-31 Improves Cognitive Function in Sepsis-Associated Encephalopathy by Inhibiting the Drp1-NLRP3 Inflammasome Activation." 01/01/2020 - "Maf1 Ameliorates Sepsis-Associated Encephalopathy by Suppressing the NF-kB/NLRP3 Inflammasome Signaling Pathway." 10/01/2023 - "Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat model." 01/01/2020 - "Ethyl pyruvate protects against sepsis-associated encephalopathy through inhibiting the NLRP3 inflammasome."
6.	NeuroglobinIBA 01/01/2014 - "To determine the role of neuroglobin in the pathology of sepsis-associated encephalopathy and ascertain if neuroglobin has any protective effects against sepsis-associated encephalopathy. " 09/01/2017 - "Neuroglobin Protects Rats from Sepsis-Associated Encephalopathy via a PI3K/Akt/Bax-Dependent Mechanism." 01/01/2014 - "We determined that sepsis-associated encephalopathy induces damage evident when examining both gross and ultrastructural morphology, as well as induces neuronal neuroglobin expression. " 01/01/2014 - "Expression and role of neuroglobin in rats with sepsis-associated encephalopathy." 01/01/2014 - "We also determined that hemin has protective effects against sepsis-associated encephalopathy as well, most probably due to its effect on neuroglobin."
7.	NF-kappa B (NF-kB)IBA 01/01/2020 - "Maf1 Ameliorates Sepsis-Associated Encephalopathy by Suppressing the NF-kB/NLRP3 Inflammasome Signaling Pathway." 01/01/2020 - "Glycemic control with insulin attenuates sepsis-associated encephalopathy by inhibiting glial activation via the suppression of the nuclear factor kappa B and mitogen-activated protein kinase signaling pathways in septic rats."
8.	MelatoninIBA 03/01/2018 - "Short- and Long-Term Protective Effects of Melatonin in a Mouse Model of Sepsis-Associated Encephalopathy." 09/21/2023 - "Potential Neuroprotective Role of Melatonin in Sepsis-Associated Encephalopathy Due to Its Scavenging and Anti-Oxidative Properties."
9.	Hemin (Panhematin)FDA Link 01/01/2014 - "We also determined that hemin has protective effects against sepsis-associated encephalopathy as well, most probably due to its effect on neuroglobin." 01/01/2014 - "Hematin and neuroglobin: contenders for prevention and treatment of sepsis-associated encephalopathy?" 01/01/2014 - "The rats were then left untreated to examine the effect of sepsis-associated encephalopathy on neuroglobin, treated with a neuroglobin antisense nucleotide to block gene expression, or given hemin, a neuroglobin inducer. "
10.	Caspase 3 (Caspase-3)IBA 07/01/2018 - "Sevoflurane exerts brain-protective effects against sepsis-associated encephalopathy and memory impairment through caspase 3/9 and Bax/Bcl signaling pathway in a rat model of sepsis."

Therapies and Procedures

1.	Ligation 01/01/2022 - "Sepsis associated encephalopathy rats underwent cecal ligation and perforation (CLP) surgery. " 01/01/2019 - "In the present study, C57BL/6 mice were subjected to cecal ligation and puncture (CLP) to mimic the clinical human sepsis-associated encephalopathy. " 03/11/2023 - "The Absence of Gasdermin D Reduces Nuclear Autophagy in a Cecal Ligation and Puncture-Induced Sepsis-Associated Encephalopathy Mouse Model." 01/01/2022 - "Zhang, et al. (mSystems 7:e01399-21, 2022, https://doi.org/10.1128/msystems.01399-21) on the role of gut microbiota and bacterial metabolites in mediating sepsis-associated encephalopathy in a mouse model of cecal puncture and ligation." 10/01/2021 - "Our previous study showed that SEI was protective against sepsis-associated encephalopathy and the present study was performed to investigate the role of SEI in sepsis-induced lung injury in a murine model of cecal ligation and puncture (CLP). "
2.	Punctures 01/01/2019 - "In the present study, C57BL/6 mice were subjected to cecal ligation and puncture (CLP) to mimic the clinical human sepsis-associated encephalopathy. " 03/11/2023 - "The Absence of Gasdermin D Reduces Nuclear Autophagy in a Cecal Ligation and Puncture-Induced Sepsis-Associated Encephalopathy Mouse Model." 01/01/2022 - "Zhang, et al. (mSystems 7:e01399-21, 2022, https://doi.org/10.1128/msystems.01399-21) on the role of gut microbiota and bacterial metabolites in mediating sepsis-associated encephalopathy in a mouse model of cecal puncture and ligation." 10/01/2021 - "Our previous study showed that SEI was protective against sepsis-associated encephalopathy and the present study was performed to investigate the role of SEI in sepsis-induced lung injury in a murine model of cecal ligation and puncture (CLP). " 12/01/2017 - "Here we examined the anti-inflammatory and antioxidant effects of Ecballium elaterium (EE) on brain, and explored its therapeutic potential in an animal model of sepsis-associated encephalopathy (SAE) [induced by cecal ligation and puncture (CLP)]. "
3.	Vagus Nerve Stimulation 06/01/2015 - "[Protective effects of vagus nerve stimulation on rats with sepsis-associated encephalopathy]."
4.	Percutaneous Collagen Induction 12/25/2019 - "To observe the efficacy of "Tongdu Tiaoshen" (dredging Governor Vessel and regula-ting mind,needling on the cognitive function of patients with sepsis associated encephalopathy (SAE). "
5.	Lung Transplantation 12/22/2022 - "The aim of this study was to describe the significance of CXCL1 in selected diseases of the cardiovascular system (atherosclerosis, atrial fibrillation, chronic ischemic heart disease, hypertension, sepsis including sepsis-associated encephalopathy and sepsis-associated acute kidney injury), the respiratory system (asthma, chronic obstructive pulmonary disease (COPD), chronic rhinosinusitis, coronavirus disease 2019 (COVID-19), influenza, lung transplantation and ischemic-reperfusion injury and tuberculosis) and the skin (wound healing, psoriasis, sunburn and xeroderma pigmentosum). "