Chloride Channel Agonists

A class of drugs that stimulate chloride ion influx through cell membrane channels.

Also Known As:

Chloride Channel Activators; Chloride Channel Stimulators; Activators, Chloride Channel; Agonists, Chloride Channel; Channel Activators, Chloride; Channel Agonists, Chloride; Channel Stimulators, Chloride; Stimulators, Chloride Channel

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Membrane Transport Modulators
      - Chloride Channel Agonists: 6

Experts

1.	Chey, William D: 2 articles (01/2021 - 11/2012)
2.	Brenner, Darren M: 1 article (01/2021)
3.	Keefer, Laurie A: 1 article (01/2021)
4.	Lacy, Brian E: 1 article (01/2021)
5.	Long, Millie D: 1 article (01/2021)
6.	Moshiree, Baha: 1 article (01/2021)
7.	Pimentel, Mark: 1 article (01/2021)
8.	Malone, Michael: 1 article (03/2018)
9.	Samiullah, Samiullah: 1 article (03/2018)
10.	Waheed, Abdul: 1 article (03/2018)

Related Diseases

1.	Constipation 01/01/2021 - "We recommend the use of chloride channel activators and guanylate cyclase activators to treat global IBS with constipation symptoms. " 03/01/2018 - "Functional constipation responds to many of the same treatments as constipation-predominant IBS, which include guanylate cyclase-C agonists and chloride channel activators. " 12/01/2006 - "Lubiprostone is the first in its class of chloride channel activators that results in improvement of symptoms of constipation. " 11/01/2012 - "Luminally acting drugs for constipation include bulking agents, surfactants, osmotics, stimulants, chloride-channel activators, probiotics, drugs that increase delivery of bile acids to the colon and natural therapies such as prunes and hemp seed extract. " 09/10/2014 - "The primary management paradigm for NBS is a structured opioid withdrawal program accompanied by centrally acting adjunctive therapy comprising antidepressants, benzodiazepines, and clonidine to target pain, anxiety, and depression, and prevent withdrawal effects, in addition to peripherally acting agents such as laxatives (e.g., osmotic laxatives and chloride channel activators) to control transient constipation. "
2.	Poisoning 02/15/2000 - "These results support the hypothesis that the voltage-dependent chloride channel is a toxicologically significant additional site of action for deltamethrin and that the use of chloride channel agonists can provide a rationale for a novel and effective therapy against type II pyrethroid poisoning."
3.	Pain (Aches) 09/10/2014 - "The primary management paradigm for NBS is a structured opioid withdrawal program accompanied by centrally acting adjunctive therapy comprising antidepressants, benzodiazepines, and clonidine to target pain, anxiety, and depression, and prevent withdrawal effects, in addition to peripherally acting agents such as laxatives (e.g., osmotic laxatives and chloride channel activators) to control transient constipation. "

Related Drugs and Biologics

1.	Chloride Channels (Chloride Channel)
2.	Surface-Active Agents (Surfactants)
3.	Pyrethrins (Pyrethroids)
4.	Guanylate Cyclase (Guanylyl Cyclase)
5.	Clonidine (ST 155)
6.	Bile Acids and Salts (Bile Acids)
7.	Benzodiazepines
8.	Antidepressive Agents (Antidepressants)
9.	Opioid Analgesics (Opioids)
10.	Guanylyl Cyclase C Agonists

Related Therapies and Procedures

1.	Therapeutics