Calcium Chelating Agents

Substances that bind to and sequester CALCIUM ions.

Also Known As:

Calcium Chelators; Agents, Calcium Chelating; Chelating Agents, Calcium; Chelator, Calcium; Chelators, Calcium; Calcium Chelator

Networked: 114 relevant articles (3 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Sequestering Agents: 35
      - Chelating Agents: 4090
        Calcium Chelating Agents: 114
- Specialty Uses of Chemicals
  - Sequestering Agents: 35
    - Chelating Agents: 4090
      - Calcium Chelating Agents: 114

Experts

1.	Michiels, Carine: 3 articles (01/2003 - 01/2002)
2.	Ninane, Noelle: 3 articles (01/2003 - 01/2002)
3.	Raes, Martine: 3 articles (01/2003 - 01/2002)
4.	Renard, Patricia: 3 articles (01/2003 - 01/2002)
5.	Al-Anazi, Azizah: 2 articles (12/2018 - 11/2018)
6.	Al-Hijailan, Reem: 2 articles (12/2018 - 11/2018)
7.	Al-Jufan, Mansour: 2 articles (12/2018 - 11/2018)
8.	Al-Mohanna, Futwan: 2 articles (12/2018 - 11/2018)
9.	Bazzi, Mohammed: 2 articles (12/2018 - 11/2018)
10.	Collison, Kate: 2 articles (12/2018 - 11/2018)

Related Diseases

1.	Insulin Resistance 01/01/2019 - "PA also translocated the tfR1 by stimulating calcium influx, but the calcium chelator, BAPTA-AM, dramatically reduced iron overload by inhibiting tfR1 translocation and ultimately increased insulin sensitivity. " 01/01/2017 - "The elevated insulin sensitivity mediated by ATP2B1 gene silencing was Ca2+/calmodulin-dependent, as verified by administration of the calcium chelator BAPTA-AM or the calmodulin-specific antagonist W7. " 01/01/2008 - "The effects on IR function were completely blocked by NMDA receptor antagonists, tetrodotoxin, and calcium chelator BAPTA-AM. Downstream from the IR, ADDLs induced a phosphorylation of Akt at serine473, a modification associated with neurodegenerative and insulin resistance diseases. "
2.	Iron Overload 01/01/2019 - "PA also translocated the tfR1 by stimulating calcium influx, but the calcium chelator, BAPTA-AM, dramatically reduced iron overload by inhibiting tfR1 translocation and ultimately increased insulin sensitivity. " 10/01/2021 - "Primary chondrocytes were treated with various concentrations of ferric ammonium citrate (FAC) to mimic iron overload in vitro, followed by co‑treatment with the calcium chelator BAPTA acetoxymethyl ester (BAPTA‑AM). "
3.	Heart Arrest (Cardiac Arrest) 03/01/1981 - "Renografin-60, containing the greatest amount of calcium-chelating agents, produced a significantly greater degree of terminal asystole (P less than 0.05), which was reversible upon addition of CaCl2. "
4.	Brain Ischemia (Cerebral Ischemia) 12/01/2006 - "BAPTA-AM is the acetoxymethylester of the calcium chelator BAPTA and has demonstrated efficacy in several animal models of cerebral ischemia. "
5.	Kidney Calculi (Kidney Stone) 11/01/1977 - "Pellets made by dispersing microcrystals of calcium oxalate monohydrate throughout an organic matrix have served as models for kidney stones in studies of factors governing their dissolution by calcium-chelating agents. " 12/01/2018 - "The results obtained from the renal expression of NaDC1 could explain an adaptive mechanism to prevent the formation of kidney stones by increasing the levels of citrate, a calcium chelator. " 01/01/2020 - "In this study hexametaphosphate (HMP), a potent calcium chelator, was found to be 12 times more effective at dissolving calcium oxalate, the primary component of kidney stones, than citrate. "

Related Drugs and Biologics

1.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester
2.	Calcium
3.	1,2- bis(2- aminophenoxy)ethane- N,N,N',N'- tetraacetic acid (BAPTA)
4.	Proteins (Proteins, Gene)
5.	Calcium Oxalate
6.	Acids
7.	Edetic Acid (EDTA)
8.	Citric Acid (Citrate)
9.	Proteasome Inhibitors
10.	Protein Isoforms (Isoforms)

Related Therapies and Procedures

1.	Intraventricular Injections
2.	Injections
3.	Electrodes (Electrode)
4.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
5.	Aftercare (After-Treatment)