Phospholipase A2 Inhibitors

Compounds that inhibit or block the activity of a PHOSPHOLIPASE A2 enzyme.

Also Known As:

Phospholipase A2 Antagonists; A2 Antagonists, Phospholipase; A2 Inhibitors, Phospholipase; Antagonists, Phospholipase A2; Inhibitors, Phospholipase A2

Networked: 30 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Enzyme Inhibitors: 1659
      - Phospholipase A2 Inhibitors: 30

Experts

1.	Bittencourt Rodrigues, Caroline Fabri: 1 article (07/2022)
2.	Carvalho de Souza, Daniel: 1 article (07/2022)
3.	Grego, Kathleen Fernandes: 1 article (07/2022)
4.	Hatakeyama, Daniela Miki: 1 article (07/2022)
5.	Kavazoi, Victor Koiti: 1 article (07/2022)
6.	Serino-Silva, Caroline: 1 article (07/2022)
7.	Tanaka-Azevedo, Anita Mitico: 1 article (07/2022)
8.	de Morais-Zani, Karen: 1 article (07/2022)
9.	Ke, Hua-Jing: 1 article (01/2020)
10.	Liao, Gen-You: 1 article (01/2020)

Related Diseases

1.	Atherosclerosis 10/01/2009 - "Phospholipase A2 inhibitors in the treatment of atherosclerosis: a new approach moves forward in the clinic." 02/21/2009 - "Phospholipase A2 inhibitors in atherosclerosis: the race is on." 10/01/2009 - "Phase II results of the trials of two phospholipase A2 inhibitors which may be of value in the treatment of atherosclerosis and cardiovascular disease have been reported in the past year. " 05/01/2005 - "Phospholipase A2 inhibitors specific for enzyme isoforms are actively studied as potential antiallergic/antiasthmatic drugs, antiarthritic agents and therapeutics for atherosclerosis."
2.	Cardiovascular Diseases (Cardiovascular Disease) 02/01/2009 - "Future role for selective phospholipase A2 inhibitors in the prevention of atherosclerotic cardiovascular disease." 01/01/2007 - "The therapeutic potential of phospholipase A2 inhibitors in cardiovascular disease." 10/01/2009 - "Phase II results of the trials of two phospholipase A2 inhibitors which may be of value in the treatment of atherosclerosis and cardiovascular disease have been reported in the past year. "
3.	Inflammation (Inflammations) 12/01/2003 - "Extracellular phospholipase A2 inhibitors suppress central nervous system inflammation." 05/01/1995 - "Inhibition of allergic and non-allergic inflammation by phospholipase A2 inhibitors." 01/01/2007 - "Chemistry and structural evaluation of different phospholipase A2 inhibitors in arachidonic acid pathway mediated inflammation and snake venom toxicity." 09/01/1979 - "Phospholipase A2 inhibitors may block not only the release of arachidonic acid and its subsequent conversion into prostaglandins but also the formation of lysophospholipids involved in inflammation and/or platelet aggregation."
4.	Pancreatitis 01/01/2020 - "Effects of Snake-Derived Phospholipase A2 Inhibitors on Acute Pancreatitis: In vitro and in vivo Characterization." 12/01/1985 - "[Phospholipase A2 inhibitors in hemorrhagic-necrotizing pancreatitis. " 01/01/1980 - "Phospholipase A2 inhibitors and their possible clinical use in the treatment of acute pancreatitis."
5.	Reperfusion Injury 09/01/1993 - "Radical scavengers and phospholipase A2 inhibitors may prevent reperfusion damage of the intestine, even when the treatment starts during ischemia but before reperfusion." 02/01/1993 - "The aims were to examine the possibility of reperfusion damage in a canine model involving 2 hours of complete segmental ischemia and to investigate the effects of antioxidant therapy or pretreatment with nonspecific phospholipase A2 inhibitors on postocclusive mucosal changes. "

Related Drugs and Biologics

1.	Arachidonic Acid (Vitamin F)
2.	Dinoprostone (PGE2)
3.	Venoms
4.	Phospholipases A2 (Phospholipase A2)
5.	Caspase 3 (Caspase-3)
6.	Metalloproteases (Metalloproteinases)
7.	C-Type Lectins (C-Type Lectin)
8.	Protein Isoforms (Isoforms)
9.	Protein Disulfide-Isomerases
10.	Acetic Acid (Vinegar)

Related Therapies and Procedures

1.	Therapeutics