Teratogenesis

01/01/2006 - "Together, their results demonstrate that (a) RXR/RAR heterodimers in which RXR is either transcriptionally active or silent are involved in the transduction of the RA signal during prenatal development, (b) specific RXRalpha/RAR heterodimers are required at many distinct stages during early embryogenesis and organogenesis, (c) the physiological role of RA and its receptors cannot be extrapolated from teratogenesis studies using retinoids in excess. "
01/01/1995 - "Teratogenesis studies suggest that both retinoid excess and deficiency are capable of disrupting the development of these axes. "
01/01/1988 - "Our results indicate that pharmacokinetic studies are essential for the interpretation of relative teratogenic potencies of retinoids as well as apparent differences between in vivo and in vitro teratogenesis. "
10/03/1985 - "The pattern of malformation closely resembled that produced in animal studies of retinoid teratogenesis. "
04/01/1982 - "In addition to teratogenesis studies, experiments designed to evaluate the effects of the retinoids on fertility and reproductive performance and on perinatal and postnatal development are also described."

06/01/2005 - "Studies that illustrate agents that are effective in diminishing or exacerbating ethanol's teratogenesis have also been helpful in determining mechanisms. "
01/01/2014 - "This suggests the D2 maternal uterine environment did not offer any protection against ethanol teratogenesis for B6 fetuses. "
09/01/2012 - "Our study identified several classes of genes with altered expression following prenatal alcohol exposure, including many specific for B6, a strain susceptible to ethanol teratogenesis. "
10/21/2011 - "We further characterize in this study the proteomic architecture underlying the role of ADNF-9 against ethanol teratogenesis during early fetal brain development using liquid chromatography in conjunction with tandem mass spectrometry (LC-MS/MS). "
07/01/2011 - "The current study tested the hypothesis that fetal genotype is an important determinant of ethanol teratogenesis by evaluating effects of ethanol exposure via embryo culture in 3 inbred strains of mice known to differ in the vulnerability of prenatal alcohol exposure in vivo. "

10/01/2000 - "Role of oxidative damage in arsenic-induced teratogenesis."
09/01/1999 - "In order to examine interactions between arsenite administration during neurulation and murine genotype, the present study compares two inbred mouse strains, establishes a teratogenic dose of arsenite, and evaluates the effect of the splotch mutation on arsenic-induced teratogenesis. "
03/01/1998 - "With a view to further investigating teratogenicity, embryotoxicity and teratogenic mechanism of arsenic on developing embryos, the relationship between apoptosis (programmed cell death, PCD) and arsenic-induced teratogenesis was studied during head-fold stage by using in situ 3'end-labeling of DNA and Nile blue sulfate (NBS) vital staining. "
06/01/1969 - "Interrelationships of selenium, cadmium, and arsenic in mammalian teratogenesis."
03/01/1995 - "DMSA and DMPS were found to be effective in alleviating arsenate- and arsenite-induced teratogenesis, whereas BAL afforded only some protection against arsenic-induced embryo/fetal toxicity. "

08/01/1993 - "Effects of meso-2,3-dimercaptosuccinic acid (DMSA) on methyl mercury-induced teratogenesis in mice."
03/01/1995 - "DMSA and DMPS were found to be effective in alleviating arsenate- and arsenite-induced teratogenesis, whereas BAL afforded only some protection against arsenic-induced embryo/fetal toxicity. "
06/01/1994 - "meso-2,3-Dimercaptosuccinic acid (DMSA) and sodium 2,3-dimercaptopropane-1-sulfonate (DMPS) have been reported to be effective in alleviating arsenic- and mercury-induced teratogenesis, whereas sodium 4,5-dihydroxybenzene-1,3-disulfonate (Tiron) would protect against vanadium- and uranium-induced developmental toxicity."

03/01/1995 - "DMSA and DMPS were found to be effective in alleviating arsenate- and arsenite-induced teratogenesis, whereas BAL afforded only some protection against arsenic-induced embryo/fetal toxicity. "
06/01/1994 - "meso-2,3-Dimercaptosuccinic acid (DMSA) and sodium 2,3-dimercaptopropane-1-sulfonate (DMPS) have been reported to be effective in alleviating arsenic- and mercury-induced teratogenesis, whereas sodium 4,5-dihydroxybenzene-1,3-disulfonate (Tiron) would protect against vanadium- and uranium-induced developmental toxicity."

01/01/1990 - "Although animal studies are useful in identifying potential teratogens, they are poor predictors of human teratogenesis. "
01/01/2019 - "Presently, SIAT is expanding the research to experimental teratogenesis and to investigation of molecular mechanisms of teratogens."
12/01/2006 - "As a consequence, teratogens that induce oxidative stress (OS) may induce teratogenesis via the misregulation of these same pathways. "
04/01/2004 - "This means that each teratogen has a threshold dose below which there is no risk of teratogenesis, no matter when in pregnancy the exposure occurred. "
05/15/2001 - "Investigation of the redox status of two species that have demonstrated differential sensitivity to teratogens represents a novel approach for determining the role of redox alteration in teratogenesis. "

07/01/2020 - "The role of neuronal apoptosis in Valproic Acid brain-related teratogenesis: a histochemical and immunohistochemical study in BALB/c mice."
12/01/2018 - "Aims and methodWe aimed to evaluate clinical note documentation of valproate prescribing and establish the level of knowledge among women of child-bearing potential regarding valproate-associated adverse effects, including teratogenesis, in a regional Irish mental health service. "
12/01/2018 - "Various populations show trends for a reduction in valproate prescribing, which is associated with an increased risk of anatomical teratogenesis and neurodevelopmental effects in those exposed in utero. "
02/01/2016 - "AED pregnancy registries and prospective studies of cognitive development continue to confirm that valproate poses a significantly increased risk of structural and cognitive teratogenesis. "
04/01/2012 - "Valproate-induced teratogenesis in Japanese rice fish (Oryzias latipes) embryogenesis."

06/01/1986 - "Maternal metabolism and teratogenesis in zinc-deficient rats."
03/01/1985 - "Possible interactions between alcohol and zinc deficiency are also considered and data are presented pointing to increased fetotoxicity and teratogenesis in the presence of both treatments and to a more specific interaction with respect to reduced cell numbers in the developing rat hippocampus. "
03/01/1985 - "Attention is paid to the primary biochemical lesion associated with zinc-related teratogenesis and special consideration is given to the central nervous system. "
01/01/2005 - "Studies of humans and experimental animals show that maternal zinc deficiency can cause infertility, prolonged labor, intrauterine growth retardation, teratogenesis, severe immunological deficiencies, or fetal death. "
08/01/2010 - "Maternal zinc deficiency produces effects ranging from infertility and embryo/fetal death, to intrauterine growth retardation and teratogenesis. "

04/01/2008 - "Proteomic analysis to characterize differential mouse strain sensitivity to cadmium-induced forelimb teratogenesis."
09/01/1990 - "Dithiocarbamates and prevention of cadmium teratogenesis in the hamster."
04/01/1979 - "Reduction in cadmium teratogenesis by prior cadmium expsoure."
12/01/1985 - "Cadmium-induced forelimb ectrodactyly: a proposed mechanism of teratogenesis."
09/01/1998 - "In this study, an in vitro method of mouse limb bud culture in self-made rotator with continuous supplementation of gas mixture was employed in studying the teratogenic potential of cadmium and the influence of zinc on the teratogenesis induced by cadmium. "

10/01/2015 - "Newer antiepileptic drugs (AEDs) have increasingly shown promising results of lower rate of teratogenesis, as well as better seizure control during pregnancy. "
03/01/2019 - "Teratogenesis of 8 Antiepileptic Drugs in Multinational Experience Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Perucca E, Sabers A, Thomas SV, Vajda F for the EURAP Study Group. "
10/01/2009 - "The framework is motivated by data of the Boston Anticonvulsant Teratogenesis study and offers an integrated approach to investigate substantive questions, concerning general and anomaly-specific exposure effects of covariates, interrelations between anomalies, and objective diagnostic measurement."
03/01/1994 - "Anticonvulsant teratogenesis: I. A study design for newborn infants."
09/01/2018 - "More Than Meets the Eye: Antiepileptic Drug Use During Pregnancy and its Effects Beyond Teratogenesis."

01/01/1994 - "There appears to be no increased risk of teratogenesis in offspring exposed to chemotherapy after the first trimester of pregnancy. "
11/01/1974 - "Letter: Teratogenesis and chemotherapy."
03/01/2014 - "In pregnant women, however, chemotherapy as well as radical surgery should be avoided in the first trimester because of teratogenesis and high abortion rates. "
04/01/1991 - "These results suggest that chemotherapy can be administered during pregnancy, even during the first trimester, because it is not hazardous to the fetus; nevertheless, this study is inadequate in size to exclude the possibility of teratogenesis, and more reports are necessary to define the best treatment from cancer during pregnancy."
07/01/1980 - "Finally, we comment on the need for long-term prospective studies of fertility, teratogenesis, and mutagenesis in patients receiving cancer chemotherapy."

08/01/1997 - "The choice of an AED should be ruled by its efficacy against a given seizure type; by its toxicity, either acute, dose-related or idiosyncratic, or chronic, due to the length of therapy or AED dosage; by its capacity to interact with other drugs, either AEDs or not, mainly through pharmacokinetic interactions, leading to fluctuation in the plasma concentration of the target drug and hence decreased in their efficacy; by its potential cognitive and behavioural side effects; by its teratogenesis which is common to all AEDs; by its cost. "
01/01/2018 - "In general, targeted therapies are contraindicated during pregnancy due to concerns about teratogenesis. "
10/01/2015 - "The understanding of teratogenesis as well as novel targeted therapeutics will allow women on AEDs during their pregnancy, to receive the safest drug for their developing fetus as well as themselves."
09/01/2012 - "However, the identification of specific polymorphisms associated with predisposition to teratogenesis may allow in the future the development of personalized non-teratogenic therapies for pregnant women."
01/01/2010 - "The identification of mechanisms and outcomes for neurobehavioral teratogenesis is critical to our ability to develop therapies to ameliorate or reverse the deleterious effects of exposure to developmental neurotoxicants. "

01/01/2021 - "Fewer respondents felt confident with such counseling (teratogenesis: 90%, n = 188/208, drug interactions: 65%, n = 133/208, pregnancy 75%, n = 156/208, contraception: 47-64%, n = 96-134/208, p < 0.05). "
12/01/2018 - "These could be divided into four main categories, with many having effects across several categories: 177 drugs required contraception because they were associated with pregnancy loss or stillbirth, 177 drugs were associated with teratogenesis, 136 were associated with non-teratogenic adverse peri- or postnatal effects on the fetus (e.g. "
08/01/2020 - "These include issues such as catamenial exacerbation, concerns for contraception, teratogenesis (including both anatomical and neurodevelopmental effects), and other concerns for pregnancy complications such as increased seizures or adverse obstetric outcomes. "
01/01/2021 - "Most believed that child neurologists should counsel young WWE on: teratogenesis (99%, n = 206/207), contraception-antiseizure medication interactions (96%, n = 194/202), pregnancy (95%, n = 198/206), contraception (89%, n = 184/206) and folic acid supplementation (70%, n = 144/205). "
01/01/2020 - "Adolescent and young adult WWE have unique sexual and reproductive healthcare needs, including counseling on teratogenesis, folic acid, and interactions between contraception and antiseizure medications. "

03/01/1987 - "Important data relative to organogenesis and teratogenesis can be learned from the study of early embryos derived from induced abortions, which are legal in Japan. "
03/01/2014 - "In pregnant women, however, chemotherapy as well as radical surgery should be avoided in the first trimester because of teratogenesis and high abortion rates. "

02/01/1985 - "For teratogenesis studies, pregnant ICR albino mice were administered saccharin by three routes and at three different doses by each route as follows: Intraperitoneal injection of 500, 1,000, or 2,000 mg/kg saccharin on day 10 of gestation; intragastric tube delivery of 5, 10, or 25 mg/kg/day of saccharin on days 5-15 of gestation; and as drinking water containing a 5, 10, or 20% solution of saccharin from day 0 through day 17. "