Hyoscyamine

The 3(S)-endo isomer of atropine.

Also Known As:

Anaspaz; Atropine, 3(S)-endo-Isomer; Cytospaz; Hyoscyamine Hydrobromide; Hyoscyamine Hydrochloride; Hyoscyamine Sulfate Anhydrous; Atropine Sulfate, 3(S)-endo-Isomer; Hyoscyamine Sulfate

Networked: 58 relevant articles (6 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Helgeson, Scott A: 2 articles (01/2019 - 01/2018)
2.	Mwakyanjala, Edson J: 2 articles (01/2019 - 01/2018)
3.	Parikh, Pragnesh P: 2 articles (01/2019 - 01/2018)
4.	Venkatachalam, K L: 2 articles (01/2019 - 01/2018)
5.	Glatstein, Miguel: 2 articles (01/2016 - 11/2014)
6.	Scolnik, Dennis: 2 articles (01/2016 - 11/2014)
7.	Lembo, Anthony J: 2 articles (12/2015 - 07/2006)
8.	Kiddoo, Darcie: 2 articles (01/2011 - 10/2007)
9.	Kusumoto, Fred: 1 article (05/2022)
10.	Mai, William: 1 article (05/2022)

Related Diseases

1.	Renal Colic 02/01/2001 - "There was no clinically important difference in change of pain scores at 30 minutes in patients with ureteral colic receiving supplemental hyoscyamine sulfate." 10/01/1998 - "The efficacy of sublingual hyoscyamine sulfate and intravenous ketorolac tromethamine in the relief of ureteral colic." 02/01/2001 - "Sublingual hyoscyamine sulfate in combination with ketorolac tromethamine for ureteral colic: a randomized, double-blind, controlled trial." 10/01/1998 - "A prospective, randomized, open-label, single-dose study was conducted in an emergency department (ED) of a tertiary care teaching hospital to evaluate the efficacy of hyoscyamine sulfate as compared to ketorolac tromethamine for the reduction of pain from ureteral colic in the ED. " 02/01/2001 - "Hyoscyamine sulfate did not provide any additional pain relief from ureteral colic when administered with ketorolac tromethamine. "
2.	Pain (Aches) 05/01/1999 - "For the no-medication group (n = 36), the mean pain score was 4.1; for the placebo group (n = 34), 3.8; and for the hyoscyamine group (n = 40), 4.2. " 05/01/1999 - "Comparison of no medication, placebo, and hyoscyamine for reducing pain during a barium enema." 02/01/1999 - "For patients with infrequent but severe episodes of unpredictable pain, sublingual hyoscyamine often produces rapid relief and instills confidence. " 09/01/1998 - "The treatment groups differed with a higher percentage of the hyoscyamine group having a previous endoscopy (60.0% vs. 41.3%, p = 0.02); however, no significant differences were detected between mean pain scores as related to treatment when controlling for previous experience with endoscopy (p = 0.31). " 05/01/1999 - "Although safe, hyoscyamine seems to provide no benefit over no drug or a placebo when used as a pain premedication for patients undergoing a barium enema."
3.	Spasm (Spasms) 11/01/2002 - "Although glucagon and hyoscyamine remain options for treatment of colonic spasm, the results of this study suggest that warm water is also effective. " 09/01/2006 - "Premedication with glucagon or hyoscyamine is reported to be effective in reducing colonic spasm. " 11/01/2002 - "Methods for dealing with colonic spasm include waiting for it to subside and administration of antispasmodic agents such as glucagon or hyoscyamine. " 11/01/1993 - "Antispasmodic drugs to reduce discomfort and colonic spasm during barium enemas: comparison of oral hyoscyamine, i.v. glucagon, and no drug."
4.	Abdominal Pain (Pain, Abdominal) 07/01/2006 - "Dicyclomine and hyoscyamine, the two myorelaxants available in the United States, have not been proven effective in reducing abdominal pain in patients with IBS. " 01/01/2021 - "The aim of this review article was to examine the efficacy and safety of antispasmodics available in North America (e.g., alverine, dicyclomine, hyoscine, hyoscyamine, mebeverine, otilonium, pinaverium, and trimebutine) for the treatment of chronic abdominal pain in patients with common disorders of gut-brain interaction. " 12/01/2015 - "Current treatments for diarrhea include mu-opioid agonists (i.e., loperamide, lomotil) and bile acid sequestrants (i.e., cholestyramine) while treatments for abdominal pain include antispasmodics (i.e., hyoscyamine, dicyclomine) and tricyclic antidepressants (i.e., amitriptyline). "
5.	Muscle Spasticity (Spastic) 05/02/1958 - "I. Use of a hyoscyamine preparation in spastic disorders of the gastrointestinal tract]." 04/01/1987 - "Either nifedipine or hyoscyamine would appear to be potentially effective for the treatment of oesophago-spastic and other hypertensive motor disorders, but hyoscyamine may lead to prolongation of acid clearance from the oesophagus."

Related Drugs and Biologics

1.	Ketorolac Tromethamine (Acular)
2.	Acids
3.	Glucagon (Glukagon)
4.	Dicyclomine (Bentyl)
5.	Cholinergic Agents (Cholinergics)
6.	Nifedipine (Adalat)
7.	Nootropic Agents (Nootropics)
8.	Analgesics (Analgesic Drugs)
9.	Atropine
10.	Hexamethonium (Hexamethonium Bromide)

Related Therapies and Procedures

1.	Premedication
2.	Hypnosis (Mesmerism)
3.	Sigmoidoscopes
4.	Therapeutics