Diarylquinolines

A class of quinoline compounds defined by the presence of two aromatic ring structures which are attached via a side chain to carbon 3 of the qunolinyl structure. The two aromatic moieties are typically NAPTHALENE and BENZENE. Several compounds in this class are used as ANTITUBERCULAR AGENTS.

Also Known As:

Diaryl Quinoline Derivatives; Diarylquinoline Derivatives; Derivative, Diaryl Quinoline; Derivative, Diarylquinoline; Derivatives, Diaryl Quinoline; Derivatives, Diarylquinoline; Quinoline Derivative, Diaryl; Quinoline Derivatives, Diaryl; Diaryl Quinoline Derivative; Diarylquinoline; Diarylquinoline Derivative

Networked: 42 relevant articles (7 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Diarylquinolines: 42
        bedaquiline: 650
        TBAJ-876: 4
        N-((6-bromo-2-methoxyquinolin-3-yl)(phenyl)methl)-N-(3,4-dichlorophenyl)-3-(4-methylpiperazin-1-yl)propanamide: 1

Experts

1.	Andries, Koen: 11 articles (10/2017 - 06/2007)
2.	Lounis, Nacer: 5 articles (12/2016 - 01/2009)
3.	Upton, Anna M: 4 articles (11/2021 - 10/2017)
4.	Guillemont, Jerome: 4 articles (10/2017 - 06/2007)
5.	Nuermberger, Eric L: 3 articles (11/2021 - 01/2021)
6.	Cooper, Christopher B: 3 articles (01/2020 - 10/2017)
7.	De Marez, Tine: 3 articles (02/2016 - 06/2009)
8.	Diacon, Andreas H: 3 articles (02/2016 - 06/2009)
9.	Meyvisch, Paul: 3 articles (02/2016 - 06/2009)
10.	van Heeswijk, Rolf P G: 3 articles (02/2016 - 06/2009)

Related Diseases

1.	Tuberculosis (Tuberculoses) 06/01/2019 - "Ion mobility-mass spectrometry analysis of diarylquinoline diastereomers: Drugs used for tuberculosis treatment." 03/01/2005 - "A potentially new treatment for tuberculosis; will a diarylquinoline work for leprosy?" 08/01/2011 - "Three successful examples are illustrated in this review, namely spiroindolone, thiazolidinone, and diarylquinoline for the treatment of malaria, hepatitis C virus, and tuberculosis, respectively. " 01/01/2021 - "Comparative Efficacy of the Novel Diarylquinoline TBAJ-587 and Bedaquiline against a Resistant Rv0678 Mutant in a Mouse Model of Tuberculosis." 01/01/2022 - "Bedaquiline is a diarylquinoline antimycobacterial drug and a key component of several regimens in clinical development for the treatment of tuberculosis (TB) but with ongoing phase 3 trials that include assessment of simplified dosing. "
2.	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 10/01/2021 - "A systematic review of pharmacoeconomic evaluations on oral diarylquinoline-based treatment for drug-resistant tuberculosis: from high to low burden countries." 02/01/2016 - "Bedaquiline, a diarylquinoline, improved cure rates when added to a multidrug-resistant tuberculosis (MDR-TB) treatment regimen in a previous placebo-controlled, phase 2 trial (TMC207-C208; NCT00449644). " 10/01/2021 - "Introduction: There is a rising global interest in the pharmacoeconomic evaluations of bedaquiline (BDQ), a novel oral diarylquinoline, for treatment of drug-resistant tuberculosis (DR-TB).Areas covered: This article systematically reviewed publications retrieved from Medline, American Psychological Association-Psychology information, Web of Science, Embase, Scopus, Science direct, Center for Reviews and Dissemination, and CINAHL Complete during 2010-2020 on pharmacoeconomic studies on BDQ for DR-TB treatment. " 12/01/2016 - "The aim of this study was to establish standardized drug susceptibility testing (DST) methodologies and reference MIC quality control (QC) ranges for bedaquiline, a diarylquinoline antimycobacterial, used in the treatment of adults with multidrug-resistant tuberculosis. " 08/01/2022 - "A new drug Bedaquiline, a diarylquinoline agent has been approved by the Food and Drug Administration for the treatment of pulmonary multidrug-resistant tuberculosis. "
3.	Leprosy (Hansen's Disease) 03/01/2005 - "A potentially new treatment for tuberculosis; will a diarylquinoline work for leprosy?"
4.	Pulmonary Tuberculosis 06/01/2012 - "The 2-year follow-up results for a randomized placebo-controlled study of 47 patients with multidrug-resistant pulmonary tuberculosis treated with either the new diarylquinoline TMC207, recently renamed bedaquiline, or placebo, added to the first 8 weeks of a background regimen, are presented. " 08/01/2022 - "Bedaquiline: A Novel Diarylquinoline for Multidrug-Resistant Pulmonary Tuberculosis." 08/01/2008 - "Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis." 10/01/2014 - "Bedaquiline, a diarylquinoline antibiotic, has been authorised in the EU, in combination with other antibiotics, for patients with multidrug-resistant pulmonary tuberculosis. "
5.	Neoplasms (Cancer) 03/01/2013 - "In this study, nine diarylquinoline compounds were screened for cytotoxic activity against human tumor cells, and their mechanisms of action were investigated. "

Related Drugs and Biologics

1.	bedaquiline (R207910)
2.	TBAJ-876
3.	Adenosine Triphosphate (ATP)
4.	Anti-Bacterial Agents (Antibiotics)
5.	Proteins (Proteins, Gene)
6.	Nitroimidazoles
7.	Antitubercular Agents
8.	Potassium Channels (Potassium Channel)
9.	Enzymes
10.	pretomanid

Related Therapies and Procedures

1.	Therapeutics