SLC4A Proteins

Bicarbonate transporters that move BICARBONATE IONS in exchange of CHLORIDE IONS or SODIUM IONS across membranes. They regulate acid-base HOMEOSTASIS, cell volume and intracellular pH. Members include CHLORIDE-BICARBONATE ANTIPORTERS (SLC4A1, 2, 3, and 9); SODIUM-COUPLED BICARBONATE TRANSPORTERS (SLC4A4 and 5, 7, 8 and 10); and a sodium borate cotransporter (SLC4A11 protein).

Also Known As:

Bicarbonate Transporter-Related Protein 1; SLC4A11 Protein; Sodium Borate Cotransporter 1; Solute Carrier Family 4 Member 11; Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 11; Bicarbonate Transporter Related Protein 1; Protein, SLC4A11; Proteins, SLC4A

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hall, Marcia: 2 articles (02/2022 - 05/2021)
2.	Karteris, Emmanouil: 2 articles (02/2022 - 05/2021)
3.	Sisu, Cristina: 2 articles (02/2022 - 05/2021)
4.	Zahra, Aeman: 2 articles (02/2022 - 05/2021)
5.	Loganathan, Sampath K: 2 articles (02/2012 - 03/2011)
6.	Quon, Anita: 2 articles (02/2012 - 03/2011)
7.	Vilas, Gonzalo L: 2 articles (02/2012 - 03/2011)
8.	Chatterjee, Jayanta: 1 article (02/2022)
9.	Dong, Qiduo: 1 article (05/2021)
10.	Jeyaneethi, Jeyarooban: 1 article (05/2021)

Related Diseases

1.	Hereditary Corneal Dystrophies 02/01/2012 - "Oligomerization of SLC4A11 protein and the severity of FECD and CHED2 corneal dystrophies caused by SLC4A11 mutations." 03/29/2011 - "Mutations in the SLC4A11 protein, reported as a sodium-coup-led borate transporter of the human plasma membrane, are responsible for three corneal dystrophies (CD): congenital hereditary endothelial dystrophy type 2, Harboyan syndrome, and late-onset Fuch's CD. "
2.	Endometrial Neoplasms (Endometrial Cancer) 02/02/2022 - "Out of these 30 mutations identified, only a missense mutation (i.e., R831C/R804C in uterine corpus endometrial carcinomas, UCEC) was suggestive of structural damage on the SLC4A11 protein. "
3.	Ovarian Neoplasms (Ovarian Cancer) 05/05/2021 - "Out of these seven genes, Keratin 4 (KRT4) appears to be a biomarker of exposure-associated ovarian cancer, whereas Guanylate Binding Protein 5 (GBP5), long intergenic non-protein coding RNA 707 (LINC00707) and Solute Carrier Family 4 Member 11 (SLC4A11) are biomarkers of disease. "
4.	Fuchs' Endothelial Dystrophy 01/01/2020 - "To elucidate the molecular events in solute carrier family 4 member 11 (SLC4A11)-deficient corneal endothelium that lead to the endothelial dysfunction that characterizes the dystrophies associated with SLC4A11 mutations, congenital hereditary endothelial dystrophy (CHED) and Fuchs endothelial corneal dystrophy 4. Comparative transcriptomic analysis (CTA) was performed in primary human corneal endothelial cells (pHCEnC) and murine corneal endothelial cells (MCEnC) with normal and reduced levels of SLC4A11 (SLC4A11 KD pHCEnC) and Slc4a11 (Slc4a11-/- MCEnC), respectively. "
5.	Corneal dystrophy and perceptive deafness 03/29/2011 - "Mutations in the SLC4A11 protein, reported as a sodium-coup-led borate transporter of the human plasma membrane, are responsible for three corneal dystrophies (CD): congenital hereditary endothelial dystrophy type 2, Harboyan syndrome, and late-onset Fuch's CD. "

Related Drugs and Biologics

1.	Long Noncoding RNA
2.	Keratin-4 (Keratin 4)
3.	Biomarkers (Surrogate Marker)
4.	Sodium
5.	Carrier Proteins (Binding Protein)
6.	Borates