Ubiquitin-Specific Proteases

Members of the peptidase C19 family which regulate signal transduction by removing UBIQUITIN from specific protein substrates via a process known as deubiquitination or deubiquitylation.

Also Known As:

Ubiquitin-Specific Peptidases; Ubiquitin-Specific Protease Family; Peptidase, Ubiquitin-Specific; Peptidases, Ubiquitin-Specific; Protease Family, Ubiquitin-Specific; Protease, Ubiquitin-Specific; Proteases, Ubiquitin-Specific; Ubiquitin Specific Peptidase; Ubiquitin Specific Peptidases; Ubiquitin Specific Protease; Ubiquitin Specific Protease Family; Ubiquitin Specific Proteases; Ubiquitin-Specific Peptidase; Ubiquitin-Specific Protease

Networked: 864 relevant articles (5 outcomes, 98 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Endopeptidases: 633
        Ubiquitin-Specific Proteases: 864
        Tumor Necrosis Factor alpha-Induced Protein 3: 66
        COP9 Signalosome Complex: 54
        Ubiquitin-Specific Peptidase 7: 17
        Arabidopsis AMSH1 protein
        Arabidopsis AMSH3 protein
        Arabidopsis AtUBP5 protein
        Arabidopsis UBP15 protein
        Arabidopsis UBP2 protein
        Arabidopsis UBP20 protein
        Arabidopsis UBP25 protein
        Arabidopsis UBP26 protein
        Arabidopsis UBP27 protein
        C elegans T05H10.1 protein
        Drosophila Puf protein
        Drosophila trbd protein
        Drosophila Usp10 protein
        Drosophila USP2 protein
        Drosophila USP47 protein
        Drosophila USP5 protein
        Drosophila USP8 protein
        human ABRAXAS2 protein
        human MINDY4 protein
        human MYSM1 protein
        human OTUD1 protein
        human OTUD3 protein
        human OTUD4 protein
        human USP1 protein
        human USP13 protein
        human USP15 protein
        human USP17L9P protein
        human USP27X protein
        human USP29 protein
        human USP3 protein
        human USP31 protein
        human USP34 protein
        human USP38 protein
        human USP39 protein
        human USP4 protein
        human USP41 protein
        human USP45 protein
        human USP47 protein
        human USP48 protein
        human USP50 protein
        human USP51 protein
        human USP53 protein
        human USP54 protein
        mouse Abro1 protein
        mouse MYSM1 protein
        mouse Otud1 protein
        mouse Otud3 protein
        mouse Otud4 protein
        mouse Otud5 protein
        mouse Usp1 protein
        mouse Usp13 protein
        mouse Usp15 protein
        mouse Usp29 protein
        mouse USP3 protein
        mouse USP34 protein
        mouse Usp37 protein
        mouse Usp38 protein
        mouse Usp39 protein
        mouse Usp4 protein
        mouse Usp47 protein
        mouse Usp5 protein
        mouse USP50 protein
        mouse Zranb1 protein
        rat Usp22 protein
        rat Usp28 protein
        rat Usp3 protein
        rat Usp31 protein
        rat Usp4 protein
        rat Usp47 protein
        rat USP8 protein
        Saccharomyces cerevisiae Ubp7 protein
        zebrafish usp5 protein
        zebrafish USPL1 protein
  - Deubiquitinating Enzymes: 1337
    - Ubiquitin-Specific Proteases: 864

Experts

1.	Liu, Ningning: 8 articles (06/2022 - 01/2016)
2.	Liu, Wei: 8 articles (01/2022 - 06/2018)
3.	Li, Li: 6 articles (10/2022 - 06/2017)
4.	Liu, Yan: 6 articles (04/2021 - 01/2018)
5.	Chou, Margaret M: 6 articles (01/2021 - 11/2010)
6.	Deutschbein, Timo: 6 articles (01/2021 - 10/2015)
7.	Oliveira, Andre M: 6 articles (01/2021 - 03/2004)
8.	Liu, Jing: 6 articles (05/2020 - 01/2017)
9.	Zhong, Bo: 6 articles (01/2020 - 07/2010)
10.	Reincke, Martin: 6 articles (10/2019 - 07/2015)

Related Diseases

1.	Neoplasms (Cancer) 05/17/2023 - "Recent studies highlight the oncogenic role of ubiquitin specific peptidase 8 (USP8) in many cancers. " 01/01/2022 - "This study identifies the first selective inhibitors of the cancer-associated ubiquitin-specific protease 22 (USP22)." 01/01/2022 - "Several studies have demonstrated that ubiquitin-specific protease 39 (USP39) plays an oncogenic role in various cancer types. " 12/01/2021 - "In particular, a growing number of studies show the relevance to target the ubiquitin-specific protease (USP) family in various cancers. " 11/01/2021 - "Numerous studies have examined the prognostic value of ubiquitin-specific protease 7 (USP7) in cancer, but the results remain controversial. "
2.	Carcinogenesis 01/01/2018 - "Recent studies suggest that the ubiquitin-specific protease USP28 plays an important role in cellular repair and tissue remodeling, which implies that it has a direct role in carcinogenesis. " 09/08/2023 - "The ubiquitin specific protease 7 stabilizes HPV16E7 to promote HPV-mediated carcinogenesis." 07/01/2023 - "Ubiquitin-specific peptidase 18 (USP18) plays a regulatory role in tumorigenesis. " 02/17/2022 - "Ubiquitin-specific protease 15 (USP15) is a DUB that participates in many biological cell processes and regulates tumorigenesis. " 01/01/2022 - "Ubiquitin-specific protease 8 (USP8) has been recently reported to be involved in tumorigenesis. "
3.	Hepatocellular Carcinoma (Hepatoma) 10/01/2020 - "In this study, we comprehensively analysed the role of ubiquitin-specific protease 1(USP1) in hepatocellular carcinoma (HCC) using data from a set of public databases. " 04/01/2017 - "The present study investigated ubiquitin specific peptidase 39 (USP39) gene knockdown on SMMC-7721 cells in vitro and in vivo, and the role of USP39 in regulating the growth of hepatocellular carcinoma (HCC). " 12/01/2023 - "Ubiquitin-specific protease 22 (USP22) has been identified as a potential marker for cancer stem cells in hepatocellular carcinoma (HCC). " 08/01/2023 - "The ubiquitin-specific protease 5 mediated deubiquitination of LSH links metabolic regulation of ferroptosis to hepatocellular carcinoma progression." 01/01/2023 - "Dysregulation and oncogenic activities of ubiquitin specific peptidase 2a in the pathogenesis of hepatocellular carcinoma."
4.	Colonic Neoplasms (Colon Cancer) 12/01/2021 - "Ring finger 220 promotes the stemness and progression of colon cancer cells via Ubiquitin specific peptidase 22-BMI1 axis." 01/14/2020 - "We found that ubiquitin-specific protease 21 (USP21) increases Fra-1 stability by deubiquitinating Fra-1 and enhances the expression of Fra-1 target genes in colon cancer cells. " 01/01/2023 - "Here, we identify the DUB ubiquitin-specific protease 10 (USP10) as an important player in the control of colon cancer progression and a new modifier of the hypoxia response. " 11/01/2019 - "Ubiquitin-specific peptidase 22 promotes proliferation and metastasis in human colon cancer." 11/02/2018 - "Aberrant expression of ubiquitin-specific protease 6 (USP6) was involved in several diseases including cancer, while its role in the progression of colon cancer was still unclear. "
5.	Melanoma (Melanoma, Malignant) 05/01/2021 - "The present study characterized ubiquitin-specific peptidase 22 (USP22) as a deubiquitinase controlling YAP abundance and biological functions in melanoma. " 01/01/2018 - "Using a DUB trap assay to label cellular active DUBs, we have observed an increased activity of the proteasome-associated DUB, USP14 (Ubiquitin-specific peptidase 14) in melanoma cells compared with melanocytes. " 07/01/2010 - "Here we report that the deubiquitinating enzyme ubiquitin-specific protease 17 (USP17) is required for virus-induced RIG-I- and melanoma differentiation-associated protein-5 (MDA5)-mediated type I IFN signaling. " 01/01/2021 - "In addition, deletion of the deubiquitinating protease ubiquitin specific peptidase 22 (USP22) in mouse melanoma (B16-OVA) cells decreased the efficacy of T cell-mediated killing, both in vitro and in vivo, while overexpression enhanced tumor-cell sensitivity to T (OT-I) cell-mediated killing. " 01/01/2018 - "Ubiquitination is an important regulatory event for cancer hallmarks and melanoma development, and the deubiquitinating enzymes including ubiquitin-specific peptidase (USP) families are greatly implicated in modulating cancer biology. "

Related Drugs and Biologics

1.	Phosphoric Monoester Hydrolases (Phosphatases)
2.	Tensins
3.	Peptide Hydrolases (Proteases)
4.	Fluorouracil (Carac)
5.	Deubiquitinating Enzymes
6.	Proteins (Proteins, Gene)
7.	MicroRNAs (MicroRNA)
8.	Cisplatin (Platino)
9.	Interferons
10.	Ubiquitin

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Tenotomy
5.	Cardiopulmonary Resuscitation (CPR)