Member 2 Solute Carrier Family 12

Na-K-Cl transporter ubiquitously expressed. It plays a key role in salt secretion in epithelial cells and cell volume regulation in nonepithelial cells.

Also Known As:

Solute Carrier Family 12, Member 2; BSC2 Protein; BSC2 Transport Protein; Bumetanide-Sensitive Cotransporter 2; Bumetanide-Sensitive Sodium Potassium Chloride Cotransporter 2; NKCC1 Cotransporter; NKCC1 Protein; NKCC1 Transport Protein; SLC12A2 Cotransporter; SLC12A2 Protein; SLC12A2 Transporter; Sodium-Potassium-Chloride Cotransporter 1 Protein; Solute Carrier Family 12 (Sodium Potassium Chloride Transporters), Member 2; Bumetanide Sensitive Cotransporter 2; Bumetanide Sensitive Sodium Potassium Chloride Cotransporter 2; Cotransporter 2, Bumetanide-Sensitive; Cotransporter, NKCC1; Cotransporter, SLC12A2; Protein, BSC2; Protein, BSC2 Transport; Protein, NKCC1; Protein, NKCC1 Transport; Protein, SLC12A2; Sodium Potassium Chloride Cotransporter 1 Protein; Transport Protein, BSC2; Transport Protein, NKCC1; Transporter, SLC12A2

Networked: 53 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Symporters: 1442
        Solute Carrier Family 12: 13
        Sodium-Potassium-Chloride Symporters: 109
        Member 2 Solute Carrier Family 12: 53
        human SLC12A2 protein
        mouse Slc12a2 protein
        rat Slc12a2 protein
      - Solute Carrier Proteins: 34
        Sodium-Potassium-Chloride Symporters: 109
        Member 2 Solute Carrier Family 12: 53
        human SLC12A2 protein
        mouse Slc12a2 protein
        rat Slc12a2 protein
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Symporters: 1442
        Sodium-Potassium-Chloride Symporters: 109
        Member 2 Solute Carrier Family 12: 53
        human SLC12A2 protein
        mouse Slc12a2 protein
        rat Slc12a2 protein
      - Solute Carrier Proteins: 34
        Sodium-Potassium-Chloride Symporters: 109
        Member 2 Solute Carrier Family 12: 53
        human SLC12A2 protein
        mouse Slc12a2 protein
        rat Slc12a2 protein

Experts

1.	Kahle, Kristopher T: 8 articles (01/2022 - 09/2008)
2.	Sun, Dandan: 5 articles (01/2022 - 01/2003)
3.	Löscher, Wolfgang: 3 articles (01/2022 - 01/2021)
4.	Hertz, Leif: 3 articles (01/2017 - 06/2011)
5.	Song, Dan: 3 articles (01/2017 - 06/2011)
6.	Bhuiyan, Mohammad Iqbal H: 2 articles (01/2022 - 08/2017)
7.	Hasan, Md Nabiul: 2 articles (01/2022 - 01/2020)
8.	Kaila, Kai: 2 articles (01/2022 - 01/2021)
9.	Gailus, Björn: 2 articles (01/2021 - 01/2021)
10.	Gericke, Birthe: 2 articles (01/2021 - 01/2021)

Related Diseases

1.	Brain Edema (Cerebral Edema) 06/11/2014 - "The results suggest that 10% HS alleviates cerebral edema through inhibition of the NKCC1 Cotransporter, which is mediated by attenuation of TNF-α and IL-1β stimulation on NKCC1." 10/24/2006 - "The present study was aimed to elucidate the possible role of Na+ -K+ -2Cl- -cotransporter (NKCC1) on traumatic brain injury-induced brain edema, cerebral contusion and neuronal death by using traumatic brain injury animal model. " 01/01/2014 - "Infarct size and brain edema following ischemia/reperfusion are reduced by inhibitors of the Na+, K+, 2Cl-, and water cotransporter NKCC1 and by β1-adrenoceptor antagonists. " 09/25/2023 - "EA stimulation of acupoints of the Governor Vessel can improve the degree of limb spasm and reduce the degree of cerebral edema and infarction in rats with stroke, which may be related to its functions in protecting Cl- homeostasis, up-regulating GABA concentration, and down-regulating the expression of NKCC1 protein and mRNA in the cerebral cortex. "
2.	Inflammation (Inflammations) 12/04/2021 - "In the present study, we aimed to elucidate the molecular coupling between inflammatory markers and development of iNPH and determine whether inflammation-induced hyperactivity of the choroidal Na+/K+/2Cl- cotransporter (NKCC1) that is involved in cerebrospinal fluid (CSF) secretion could contribute to the iNPH pathogenesis. " 10/01/2022 - "Recently, we have reported that patients with mutations in SLC12A2, the gene encoding the basolateral Na+-K+-2Cl- cotransporter (NKCC1), suffer from severe gastrointestinal deficits, including chronic gastrointestinal inflammation, gastrointestinal hemorrhage, intestinal obstruction, and constipation. " 09/13/2020 - "Differential proteomics found 11 proteins significantly more abundant in dysplasia compared to inflammation, including Solute carrier family 12 member 2 (SLC12A2) which was confidently identified with 8 specific peptides and was below the limit of quantitation in both inflammatory and normal colon. "
3.	Focal Cortical Dysplasia 01/01/2023 - "To observe the distribution and changes of GABAergic neurons and to explore the expression of cation chloride cotransporter NKCC1/KCC2 in focal cortical dysplasia (FCD) type II lesions is a highly significant job. " 11/08/2022 - "[Expression of cation chloride cotransporter (NKCC1/KCC2) in brain tissue of children with focal cortical dysplasia type Ⅱ]." 11/08/2022 - "Objective: To investigate the expression of cation chloride cotransporter (NKCC1/KCC2) in the neurons from cerebral lesions of children with focal cortical dysplasia (FCD) type Ⅱ, to provide a morphological basis for revealing the possible mechanism of epilepsy. " 03/02/2007 - "In the present study the expression and cell-specific distribution of Na+-K+-2Cl--cotransporter (NKCC1) and K+-Cl--cotransporter (KCC2) were studied immunocytochemically in different developmental lesions, including focal cortical dysplasia (FCD) type IIB (n=9), hemimegalencephaly (HMEG, n=6) and ganglioglioma (GG, n=9) from patients with medically intractable epilepsy and in age-matched controls. "
4.	Hypertension (High Blood Pressure) 04/01/2004 - "The Na-K-2Cl cotransporter (NKCC1) is one of several transporters that have been linked to hypertension, and its inhibition reduces vascular smooth muscle tone and blood pressure. " 05/01/2007 - "Studies in rat aorta have shown that the Na-K-2Cl cotransporter NKCC1 is activated by vasoconstrictors and inhibited by nitrovasodilators, contributes to smooth muscle tone in vitro, and is upregulated in hypertension. "
5.	Traumatic Brain Injuries (Traumatic Brain Injury) 10/24/2006 - "The present study was aimed to elucidate the possible role of Na+ -K+ -2Cl- -cotransporter (NKCC1) on traumatic brain injury-induced brain edema, cerebral contusion and neuronal death by using traumatic brain injury animal model. " 06/01/2011 - "Astrocytic swelling also occurs following brain trauma or ischemia, together with an increase in extracellular K(+) ([K(+)](o)), stimulating a bumetanide/furosemide/ethacrynic acid-inhibitable cotransporter, NKCC1, that accumulates Na(+) and K(+) together with 2 Cl(-) and osmotically obliged water. "

Related Drugs and Biologics

1.	Bumetanide (Bumex)
2.	K Cl- Cotransporters
3.	Vasoconstrictor Agents
4.	Chlorides
5.	Proteins (Proteins, Gene)
6.	gamma-Aminobutyric Acid (GABA)
7.	Cations
8.	Protein Isoforms (Isoforms)
9.	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)
10.	Sodium

Related Therapies and Procedures

1.	Acupuncture Points (Acupuncture Point)
2.	Transplantation
3.	Spinal Injections
4.	Drug Therapy (Chemotherapy)