Hepcidins

Forms of hepcidin, a cationic amphipathic peptide synthesized in the liver as a prepropeptide which is first processed into prohepcidin and then into the biologically active hepcidin forms, including in human the 20-, 22-, and 25-amino acid residue peptide forms. Hepcidin acts as a homeostatic regulators of iron metabolism and also possesses antimicrobial activity.

Also Known As:

Networked: 3019 relevant articles (120 outcomes, 520 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ganz, Tomas: 123 articles (01/2022 - 10/2002)
2.	Nemeth, Elizabeta: 112 articles (01/2022 - 04/2003)
3.	Swinkels, Dorine W: 82 articles (02/2022 - 06/2006)
4.	Camaschella, Clara: 48 articles (08/2022 - 01/2003)
5.	Vaulont, Sophie: 40 articles (01/2022 - 04/2002)
6.	Girelli, Domenico: 39 articles (10/2021 - 01/2003)
7.	Muckenthaler, Martina U: 38 articles (10/2022 - 09/2004)
8.	Drakesmith, Hal: 38 articles (12/2021 - 08/2005)
9.	Westerman, Mark: 37 articles (01/2020 - 09/2008)
10.	Babitt, Jodie L: 34 articles (01/2022 - 05/2006)

Related Diseases

1.	Anemia 01/01/2017 - "Monitoring hepcidin is helpful for the management of anemia. " 01/01/2010 - "The diagnosis of different forms of anemia will be facilitated by improved hepcidin assays, and the treatment will be enhanced by the development of hepcidin agonists and antagonists." 01/01/2023 - "The study aimed to evaluate the diagnostic value of hepcidin as a ferrokinetics marker under the development of anemia during pregnancy. " 01/01/2023 - "Study of the hepcidin level in pregnant women with and without anemia." 01/01/2021 - "Our study demonstrated a decreased hepcidin level in AG patients in comparison to CS what may have a potentially protective effect against anemia through an increased bioavailability of Fe. "
2.	Inflammation (Inflammations) 07/23/2021 - "Serum hepcidin levels were increased despite the significant reduction in inflammation. " 01/01/2021 - "We observed that inflammation and IR improved in adipose tissue of mice treated with hepcidin gene silencing. " 11/01/2021 - "This study determined the impact of heat stress on postexercise inflammation and hepcidin levels. " 11/01/2018 - "The optimization study of 1 led to the design of a potent and bioavailable inhibitor of hepcidin production, 34 (DS42450411), which showed serum hepcidin-lowering effects in a mouse model of interleukin-6-induced acute inflammation." 01/01/2017 - "The present study reveals that: 1) inflammation induces IL-1β production in Kupffer cells and hepatocytes; 2) IL-1β increases C/EBPδ expression in hepatocytes; and 3) induction of C/EBPδ activates hepcidin transcription via the C/EBP-BS that has been uncharacterized yet. "
3.	Iron Deficiencies 04/09/2014 - "Chronic elevations in hepcidin levels may help to explain the high incidence of iron deficiency in athletes." 07/01/2009 - "However, this study showed that determination of hepcidin concentrations together with M/F improved the identification of iron deficiency in pretransplant patients by 21.6%." 11/01/2010 - "Hfe Tg mice also exhibited increased hepatic BMP6-SMAD target gene expression compared with WT mice, whereas anti-BMP6 antibody administration to Hfe Tg mice improved the hepcidin excess and iron deficiency. " 11/01/2021 - "In the present study, we investigated the diagnostic features of hepcidin concentration as an iron deficiency assay during the second trimester of pregnancy. " 04/01/2021 - "The study found a significant correlation between serum hepcidin and iron deficiency-related parameters with adjustment for study groups (p<.01). "
4.	Iron Overload 06/01/2013 - "Higher hepcidin levels were protective against iron overload in infants from the 380 mg Fe/kg condition. " 01/01/2020 - "Whereas chronically treating male Hfe-/- mice with 5 mg/kg AUR activated hepatic IL-6/hepcidin signaling, decreasing systemic iron overload, but less effective in females. " 11/01/2022 - "Therefore, to address this problem, we carried out in vitro and in vivo studies using MLO-Y4 osteocyte-like cells and Hepcidin-/- mice as iron overload models. " 01/01/2022 - "This study was undertaken to determine whether PPS inhibits hepcidin-facilitated osteoclast (OC) differentiation and iron overload. " 02/01/2019 - "In this study, a zebrafish model was employed to investigate the therapeutic role of hepcidin in iron overload-induced inhibition of bone formation. "
5.	Infections 04/01/2020 - "The results showed that in the prevention groups, 30 and 90 mg/kg of added purified and unpurified hepcidin respectively resulted in a higher survival rate in the early post-infection period, while 60 mg/kg of purified hepcidin significantly improved the survival rate in the therapy group (all compared to the control group). " 08/01/2023 - "In this study we have integrated hepcidin-piscidin modulation with the effects of infection on skin mucosa, serum and hepatocyte morphology. " 01/01/2016 - "Serum hepcidin concentrations were measured by tandem mass spectrometry in samples taken in 2000 from 675 infection-free participants of the prospective population-based Bruneck study (age, mean±standard deviation, 66.0±10.2; 48.1% male). " 04/25/2013 - "Our study provides clinical pediatric data on the role of hepcidin in the face of an acute infection. " 01/01/2012 - "In this study, we aim to examine the interactions between HCV infection and hepcidin expression in liver cells. "

Related Drugs and Biologics

1.	Iron
2.	Interleukin-6 (Interleukin 6)
3.	Ferritins (Ferritin)
4.	Erythropoietin
5.	Proteins (Proteins, Gene)
6.	Hepcidins
7.	Messenger RNA (mRNA)
8.	Interferons
9.	metal transporting protein 1 (ferroportin)
10.	Hemoglobins (Hemoglobin)

Related Therapies and Procedures

1.	Therapeutics
2.	Gastrectomy
3.	Renal Dialysis (Hemodialysis)
4.	Length of Stay
5.	Aftercare (After-Treatment)