Filamins

A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.

Also Known As:

280 kDa Actin-Binding Protein; Filamin; Filamin 1; Filamin 1-Like Protein; Filamin A; Filamin B; Filamin C; Merofilamins; alpha-Filamin; beta-Filamin; 1-Like Protein, Filamin; 1-Like Proteins, Filamin; 280 kDa Actin Binding Protein; Cs, Filamin; Filamin 1 Like Protein; Filamin 1-Like Proteins; Filamin Cs; Merofilamin; Protein, Filamin 1-Like; Proteins, Filamin 1-Like; alpha Filamin; alpha-Filamins; beta Filamin; beta-Filamins

Networked: 573 relevant articles (5 outcomes, 55 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	van der Ven, Peter F M: 17 articles (06/2021 - 01/2003)
2.	Fürst, Dieter O: 16 articles (06/2021 - 01/2003)
3.	Robertson, Stephen P: 14 articles (04/2022 - 07/2006)
4.	Akyürek, Levent M: 12 articles (01/2022 - 03/2007)
5.	Kley, Rudolf A: 9 articles (01/2017 - 08/2005)
6.	Vorgerd, Matthias: 8 articles (06/2021 - 08/2005)
7.	Mantovani, Giovanna: 7 articles (01/2021 - 03/2012)
8.	Goldfarb, Lev G: 7 articles (03/2013 - 05/2009)
9.	Peverelli, Erika: 6 articles (01/2021 - 03/2012)
10.	Spada, Anna: 6 articles (01/2021 - 03/2012)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2012 - "These results suggest that filamin-A plays a role in repair of a variety of DNA damage, that lack of filamin-A is a prognostic marker for a better outcome after DNA damage based treatment, and filamin-A can be inhibited to sensitize filamin-A positive cancer cells to therapeutic DNA damage. " 01/20/2015 - "These findings establish a functional role of filamin C in human cancers and these data will be valuable for further study of its mechanisms. " 11/01/2022 - "Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin." 12/01/2021 - "Recent evidences suggest that filamins are associated with tumors, and this case further highlights the clinical spectrum of filaminopathy." 10/02/2021 - "As key components of versatile signaling scaffolds, filamins are implicated in developmental anomalies and cancer. "
2.	Neoplasm Metastasis (Metastasis) 02/01/2022 - "Significant correlation between filamin-A expression and grade, stage, lymph node status and metastases were found. " 01/01/2022 - "Of them, filamin A (FLNA) was considered a potential driver gene of metastasis, and its low expression could enhance 5 years' relapse survival rate by 15%. " 01/01/2016 - "We found significant positive correlation between filamin A protein expression and NSCLC stage (r=0.249; p<0,05), presence of lymph node (N)(r=0.205; p<0,05) and distant metastases (M) (r=0.332; P<0.01). " 12/13/2022 - "We therefore identify filamin A editing as a critical component for angiogenesis, tumor growth, and metastasis formation." 01/01/2022 - "Filamin A Is a Potential Driver of Breast Cancer Metastasis via Regulation of MMP-1."
3.	Prostatic Neoplasms (Prostate Cancer) 09/01/2019 - "This study aims to investigate the association of filamin A with the function and morphology of prostate cancer (PCa) cells, and explore the role of filamin A in the development of PCa, in order to analyze its significance in the evolvement of PCa. " 09/01/2019 - "Biological roles of filamin a in prostate cancer cells." 01/17/2017 - "Our data show that Cao2+ via CaR- mediated signaling induces filamin A cleavage and promotes the migration in AR-deficient and highly metastatic prostate cancer cells." 04/01/2014 - "Filamin A regulates MMP-9 expression and suppresses prostate cancer cell migration and invasion." 02/01/2009 - "Nuclear versus cytoplasmic localization of filamin A in prostate cancer: immunohistochemical correlation with metastases."
4.	Adrenal Cortex Neoplasms (Adrenocortical Cancer) 01/01/2021 - "The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells."
5.	Myofibrillar Myopathy 12/13/2011 - "Linkage studies delineated a 9.76 Mb region on chromosome 7q22.1-q35 containing filamin C (FLNC), a gene previously associated with myofibrillar myopathy. " 10/01/2023 - "Here we introduce the human induced pluripotent stem cell (hiPSC) line HIMRi001-A generated from cultured dermal fibroblasts of a 60-year-old male patient with a myofibrillar myopathy, carrying a heterozygous c.4984C > T [p.Q1662X] mutation in the filamin C (FLNC)-gene, via lentiviral expression of OCT4, SOX2, KLF4 and c-MYC. " 01/01/2020 - "Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation." 08/17/2019 - "A mutation in the filamin c gene causes myofibrillar myopathy with lower motor neuron syndrome: a case report." 01/01/2019 - "We report three patients with a rare filamin C myofibrillar myopathy. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Nuclear Antigens (Extractable Nuclear Antigens)
3.	Cadherins (E-Cadherin)
4.	Growth Hormone (Somatotropin)
5.	aryl hydrocarbon receptor-interacting protein
6.	Carrier Proteins (Binding Protein)
7.	Metalloproteases (Metalloproteinases)
8.	Filamins
9.	Biomarkers (Surrogate Marker)
10.	Microfilament Proteins (Actin Binding Proteins)

Related Therapies and Procedures

1.	Injections
2.	Therapeutics
3.	Acupressure (Shiatsu)
4.	Drug Therapy (Chemotherapy)
5.	Fecal Microbiota Transplantation