Checkpoint Kinase 2

Enzyme activated in response to DNA DAMAGE involved in cell cycle arrest. The gene is located on the long (q) arm of chromosome 22 at position 12.1. In humans it is encoded by the CHEK2 gene.

Also Known As:

CDS1 Kinase; CHEK2 Kinase; Checkpoint-Like Protein CHK2; Chk2 Protein Kinase; LFS2 Protein Kinase; PP1425 Protein Kinase; Serine Threonine Protein Kinase Chk2; Serine-Threonine-Protein Kinase CHK2; hCHK2 Kinase; CHK2, Checkpoint-Like Protein; CHK2, Serine-Threonine-Protein Kinase; Checkpoint Like Protein CHK2; Kinase 2, Checkpoint; Kinase CHK2, Serine-Threonine-Protein; Kinase, CDS1; Kinase, CHEK2; Kinase, Chk2 Protein; Kinase, LFS2 Protein; Kinase, PP1425 Protein; Kinase, hCHK2; Protein CHK2, Checkpoint-Like; Protein Kinase, Chk2; Protein Kinase, LFS2; Protein Kinase, PP1425

Networked: 199 relevant articles (1 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Ying: 3 articles (01/2020 - 10/2013)
2.	Jang, Kyung Lib: 3 articles (11/2019 - 01/2017)
3.	Chen, Yu-Jen: 3 articles (02/2019 - 05/2009)
4.	Attia, Yasmin M: 3 articles (02/2018 - 07/2017)
5.	El Abd, Yasmine S: 3 articles (02/2018 - 07/2017)
6.	El-Shenawy, Reem: 3 articles (02/2018 - 07/2017)
7.	Galal, Shadia A: 3 articles (02/2018 - 07/2017)
8.	Shouman, Samia A: 3 articles (02/2018 - 07/2017)
9.	Tabll, Ashraf: 3 articles (02/2018 - 07/2017)
10.	Chou, Wen-Cheng: 3 articles (08/2015 - 02/2006)

Related Diseases

1.	Ataxia Telangiectasia (Louis Bar Syndrome) 01/01/2020 - "The protective effects of DAXX may be related to the activation of the ataxia telangiectasia mutated (ATM)-checkpoint kinase 2 (ATM-CHK2)-cell division cycle 25c (CDC25c) signaling pathways in Gap2/Mitosis (G2/M) checkpoint and ultimately cell cycle arrest at G2/M phase. " 09/25/2020 - "Lastly, DNA damage responses were evaluated by detecting the active form of ataxia telangiectasia mutated/checkpoint kinase 2 (ATM/CHK2) by western blot. " 03/01/2019 - "FBC caused cell cycle arrest at S and G2/M phases, which was associated with up-regulated ataxia telangiectasia mutated (atm), checkpoint kinase 2 (chk2), structural maintenance of chromosomes 1 (smc1) and cell division cycle 25 homolog A (cdc25a) genes. " 01/01/2017 - "For this effect, HCV core sequentially activated ataxia telangiectasia mutated and checkpoint kinase 2 via phosphorylation at Ser-1981 and Thr-68 residues, respectively, resulting in stabilization of p53 via phosphorylation at Ser-15 and Ser-20 residues and subsequent transcriptional activation of PA28γ expression. " 10/02/2015 - "This phenotype correlated with a rapid and long-lasting ataxia telangiectasia-mutated (ATM) activation and phosphorylation of checkpoint kinase 2 (CHK2). "
2.	Neoplasms (Cancer) 11/01/2014 - "The aim of the current study is to explore the expression and phosphorylation of checkpoint kinase 2 (Chk2) and TP53, which are key molecules in DDR, and their clinicopathological correlation in the appendiceal tumors. " 03/08/2023 - "Checkpoint kinase 2 (CHEK2) germline loss-of-function variants have been reported in pediatric cancer patients, but clinical phenotypes and outcomes are poorly described. " 01/01/2023 - "Germline Checkpoint Kinase 2 gene (CHEK2) mutations can increase the risk of solid tumors. " 01/01/2022 - "Heterozygous carriers of germline loss-of-function variants in the tumor suppressor gene checkpoint kinase 2 (CHEK2) are at an increased risk for developing breast and other cancers. " 01/01/2020 - "Checkpoint kinase 2 (CHK2) participates in several cellular physiology pathways and plays a role in tumor progression. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "Breast cancer gene (BRCA) 1 and 2 mutations are frequently studied gene mutations (GM); the incidence of checkpoint kinase 2 (CHEK2) is increasing. " 06/01/2019 - "Pathogenic germline variants in checkpoint kinase 2 (CHEK2), which plays pivotal roles in DNA damage response and cell cycle regulation, confer an increased breast cancer (BC) risk. " 01/01/2018 - "The association between the checkpoint kinase 21100delC (CHEK21100delC) and breast cancer has been extensively explored. " 01/01/2014 - "Immunoblotting showed DCP-induced activation of DNA damage pathways, including double-phosphorylated checkpoint kinase 2 (CHK2) and breast cancer 1 (BRCA1) and triple-phosphorylated p53, compared to controls. " 09/20/2011 - "Checkpoint kinase 2 (CHEK2) is a moderate penetrance breast cancer risk gene, whose truncating mutation 1100delC increases the risk about twofold. "
4.	Ovarian Neoplasms (Ovarian Cancer) 06/01/2014 - "Ovarian cancer cell lines with stable checkpoint kinase 2 (Chk2) knock down were used to study cell cycle distribution and survival in long-term clonogenic survival assays. " 02/14/2019 - "Nevertheless, the roles of checkpoint kinase 2 (Chk2) and p27 kip1 (p27) in TF3-mediated inhibition of human ovarian cancer cells have not yet been investigated. " 01/01/2019 - "Genetic variations in CHEK2 (checkpoint kinase 2) gene have been associated with hereditary predisposition to various cancers including breast and ovarian cancer. " 06/01/2014 - "Checkpoint kinase 2 (Chk2) supports sensitivity to platinum-based treatment in high grade serous ovarian cancer." 08/01/2010 - "Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells."
5.	Prostatic Neoplasms (Prostate Cancer) 10/01/2022 - "The first Japanese case of intraductal cancer of the prostate with checkpoint kinase 2 mutation." 11/01/2006 - "A large germline deletion in the Chek2 kinase gene is associated with an increased risk of prostate cancer." 12/01/2015 - "A high-throughput RNAi screen to identify signaling pathways regulating prostate cancer cell growth led to our discovery that checkpoint kinase 2 (CHK2) knockdown dramatically increased prostate cancer growth and hypersensitized cells to low androgen levels. " 12/01/2015 - "Checkpoint Kinase 2 Negatively Regulates Androgen Sensitivity and Prostate Cancer Cell Growth." 05/01/2007 - "Previous studies have indicated that d,l-sulforaphane (SFN), a synthetic cancer chemopreventive analogue of cruciferous vegetable-derived isomer (-)-1-isothiocyanato-(4R)-(methylsulfinyl)-butane, activates a checkpoint kinase 2 (Chk2)-dependent G(2)-M phase cell cycle arrest in p53-deficient human prostate cancer cells. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Histones (Histone)
3.	Phosphotransferases (Kinase)
4.	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
5.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
6.	DNA (Deoxyribonucleic Acid)
7.	Caspase 8 (Caspase-8)
8.	Checkpoint Kinase 1
9.	Caspase 3 (Caspase-3)
10.	DNA-Activated Protein Kinase

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)