3-Phosphoinositide-Dependent Protein Kinases

Highly conserved protein-serine threonine kinases that phosphorylate and activate a group of AGC protein kinases, especially in response to the production of the SECOND MESSENGERS, phosphatidylinositol 3,4,-biphosphate (PtdIns(3,4)P2) and phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3).

Also Known As:

3-Phosphoinositide Dependent Protein Kinase-1; 3-Phosphoinositide Dependent Protein Kinase-2; 3-Phosphoinositide-Dependent Kinase 1 (PDK1); 3-Phosphoinositide-Dependent Protein Kinase; 3-Phosphoinositide-Dependent Protein Kinase-1; 3-Phosphoinositide-Dependent Protein Kinase-2; PtdIns(3,4,5)P3-Dependent Protein Kinase-1; 3 Phosphoinositide Dependent Protein Kinase; 3 Phosphoinositide Dependent Protein Kinase 1; 3 Phosphoinositide Dependent Protein Kinase 2; 3 Phosphoinositide Dependent Protein Kinases; Kinase, 3-Phosphoinositide-Dependent Protein; Kinase-1, 3-Phosphoinositide-Dependent Protein; Kinase-2, 3-Phosphoinositide-Dependent Protein; Kinases, 3-Phosphoinositide-Dependent Protein; Protein Kinase, 3-Phosphoinositide-Dependent; Protein Kinase-1, 3-Phosphoinositide-Dependent; Protein Kinase-2, 3-Phosphoinositide-Dependent; Protein Kinases, 3-Phosphoinositide-Dependent

Networked: 86 relevant articles (0 outcomes, 10 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Glazer, Robert I: 6 articles (01/2011 - 06/2002)
2.	Falasca, Marco: 4 articles (10/2019 - 01/2013)
3.	Zeng, Xiao: 4 articles (01/2011 - 06/2002)
4.	Rapposelli, Simona: 3 articles (10/2019 - 01/2019)
5.	Sestito, Simona: 3 articles (10/2019 - 01/2019)
6.	Primo, Luca: 3 articles (01/2018 - 08/2014)
7.	Puliafito, Alberto: 3 articles (01/2018 - 08/2014)
8.	Capone, Emily: 2 articles (10/2019 - 05/2019)
9.	Sala, Gianluca: 2 articles (10/2019 - 05/2019)
10.	Ferro, Riccardo: 2 articles (05/2019 - 08/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "Here, we reveal that pharmacological inhibition of the cytoplasmic activity of 3-phosphoinositide-dependent protein kinase 1 (PDK1) selectively promotes the formation of the core assembly, but not the purinosome, in cancer cells. " 07/01/2015 - "3-Phosphoinositide-dependent protein kinase 1 (PDK1) is centrally involved in cancer progression, including proliferation, apoptosis and invasion. " 08/26/2010 - "Multiple implications of 3-phosphoinositide-dependent protein kinase 1 in human cancer." 06/01/2009 - "High expression of 3-phosphoinositide-dependent protein kinase-1 (PDK1) has been detected in various invasive cancers. " 01/01/2018 - "An increasing amount of evidence hints at 3-phosphoinositide dependent protein kinase-1 (PDK1 or PDPK1) as an intriguing and underexplored target for cancer therapy. "
2.	Neoplasm Metastasis (Metastasis) 08/18/2022 - "The 3-phosphoinositide-dependent protein kinase 1 (PDPK1) has a significant role in cancer progression and metastasis as well as other inflammatory disorders, and has been proposed as a promising therapeutic target for several malignancies. " 06/01/2009 - "Down-regulation of 3-phosphoinositide-dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells." 01/01/2020 - "Overexpression of HOXC10 promoted HCC metastasis by upregulating metastasis-related genes, including 3-phosphoinositide-dependent protein kinase 1 (PDPK1) and vasodilator-stimulated phosphoprotein (VASP). " 04/01/2018 - "In the present study, HBx affected 3-phosphoinositide-dependent protein kinase-1 (PDK1) and with-no-lysine (K) kinase (WNK1) signaling, which was identified to be involved in the viability and metastasis of hepatic cells. " 10/01/2023 - "Specifically, a self-assembling dendrimer nanosystem decorated with an antibody against programmed cell death ligand 1 (PD-L1) is established for delivering a small interfering RNA (siRNA) to target 3-phosphoinositide-dependent protein kinase-1 (PDK1), a kinase involved in cancer metabolism and metastasis. "
3.	Carcinogenesis 01/13/2011 - "PPARδ activation acts cooperatively with 3-phosphoinositide-dependent protein kinase-1 to enhance mammary tumorigenesis." 11/01/2014 - "As a proof of concept, we performed tumor cell-autonomous and nonautonomous targeting, recapitulated hallmarks of human multistep carcinogenesis, validated genetic therapy by 3-phosphoinositide-dependent protein kinase inactivation as well as cancer cell depletion and show that mast cells in the tumor microenvironment, which had been thought to be key oncogenic players, are dispensable for tumor formation. " 10/01/2013 - "Although 3-phosphoinositide-dependent protein kinase-1 (PDK1) has been predominately linked to the phosphoinositide 3-kinase (PI3K)-AKT pathway, it may also evoke additional signaling outputs to promote tumorigenesis. " 04/24/2017 - "In this study, we showed that TCRP1 overexpression promotes cell transformation and tumorigenesis through hyperphosphorylation of the oncogenic kinase 3-phosphoinositide-dependent protein kinase-1 (PDK1) and AKT1, whereas inhibition of PDK1 by OSU-03012 or PDK1 small interfering RNA reversed TCRP1-mediated cell transformation. "
4.	Carcinoma (Carcinomatosis) 02/01/2016 - "This study investigated the correlation between the expression of 3-phosphoinositide-dependent protein kinase-1 (PDK1) and the prognosis of gastric carcinoma patients. " 02/01/2016 - "Overexpression of 3-phosphoinositide-dependent protein kinase-1 is associated with prognosis of gastric carcinoma." 06/01/2011 - "To explore the silencing effects of RNA interference on the expression of 3-phosphoinositide-dependent protein kinase 1 (PDK1) gene, and the effects on malignant phenotypes of esophageal carcinoma EC9706 cells. " 03/01/2007 - "3-Phosphoinositide-dependent protein kinase-1/Akt signalling and inhibition in a canine prostate carcinoma cell line."
5.	Fibrosis (Cirrhosis) 11/01/2021 - "This study aimed to investigate the effect of 3-phosphoinositide-dependent kinase 1 (PDK1) interference on the levels of fibrosis and proinflammatory factors in lipopolysaccharide (LPS)-induced ALI and discuss the relevant mechanism. " 12/26/2014 - "Activation of 3-phosphoinositide-dependent kinase 1 (PDK1) and serum- and glucocorticoid-induced protein kinase 1 (SGK1) by short-chain sphingolipid C4-ceramide rescues the trafficking defect of ΔF508-cystic fibrosis transmembrane conductance regulator (ΔF508-CFTR)."

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Small Interfering RNA (siRNA)
3.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
4.	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
5.	Phosphatidylinositols (Phosphatidylinositol)
6.	Messenger RNA (mRNA)
7.	S-Phase Kinase-Associated Proteins (Skp1 Protein)
8.	Protein Isoforms (Isoforms)
9.	Phosphatidylinositol 3-Kinases (PI 3 Kinase)
10.	Thapsigargin

Related Therapies and Procedures

1.	Electroacupuncture
2.	Therapeutics