Intrinsically Disordered Proteins

Functional proteins that do not have unique, stable, folded, three-dimensional native structures or that possess non-ordered regions under physiological conditions. They are characterized by extraordinary structural flexibility and plasticity, which enable them to adopt different conformations in response to different stimuli or different interactions.

Also Known As:

Networked: 357 relevant articles (0 outcomes, 16 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Uversky, Vladimir N: 19 articles (06/2022 - 10/2003)
2.	Vendruscolo, Michele: 12 articles (01/2022 - 01/2005)
3.	Kulkarni, Prakash: 12 articles (11/2019 - 04/2011)
4.	Dobson, Christopher M: 12 articles (01/2018 - 01/2005)
5.	Rizzuti, Bruno: 10 articles (10/2021 - 01/2017)
6.	Neira, José L: 9 articles (10/2021 - 01/2017)
7.	Santofimia-Castaño, Patricia: 8 articles (10/2021 - 01/2018)
8.	Velázquez-Campoy, Adrián: 8 articles (10/2021 - 01/2017)
9.	Iovanna, Juan L: 7 articles (10/2021 - 01/2017)
10.	Baum, Jean: 7 articles (11/2018 - 08/2009)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 01/01/2020 - "Neurodegeneration in patients with Parkinson's disease is correlated with the occurrence of Lewy bodies-intracellular inclusions that contain aggregates of the intrinsically disordered protein α-synuclein1. " 12/01/2022 - "A key pathological feature of several neurodegenerative diseases is the oligomerization and aggregation of specific intrinsically disordered proteins (IDPs) creating neuronal deposits, such as Lewy bodies in Parkinson's disease. " 01/01/2017 - "Intrinsically disordered proteins are essential for biological processes such as cell signalling, but are also associated to devastating diseases including Alzheimer's disease, Parkinson's disease or type II diabetes. " 07/17/2020 - "Recent studies suggest that Tyr-39 might play a critical role for both the normal function and the pathological dysfunction of α-synuclein (αS), an intrinsically disordered protein involved in Parkinson's disease. " 01/01/2018 - "Over the last two decades, many experimental and clinical studies have provided solid evidence that alpha-synuclein (α-syn), a small, natively unfolded protein, is closely related to Parkinson's disease (PD) pathology. "
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2020 - "Current Challenges and Limitations in the Studies of Intrinsically Disordered Proteins in Neurodegenerative Diseases by Computer Simulations." 11/14/2023 - "Mutations in intrinsically disordered proteins drive the irreversible formation of pathological aggregates, a hallmark of neurodegenerative diseases. " 10/01/2023 - "Proteasomal degradation of intrinsically disordered proteins, such as tau, is a critical component of proteostasis in both aging and neurodegenerative diseases. " 01/01/2023 - "However, aberrant phase transitions of intrinsically disordered proteins in biomolecular condensates can lead to the formation of irreversible fibrils and aggregates that are linked to neurodegenerative diseases. " 01/01/2023 - "Experimental evidence implicating Hsp90 in neurodegenerative diseases has bolstered interest in the noncanonical chaperoning of intrinsically disordered protein (IDPs), however the interplay between Hsp90 and its disordered clients remains poorly understood. "
3.	Alzheimer Disease (Alzheimer's Disease) 07/01/2011 - "We present here a study of temperature induced transitions in tau, a natively unfolded protein involved in Alzheimer's disease. " 11/01/2023 - "The intrinsically disordered protein Tau represents the main component of neurofibrillary tangles that are a hallmark of Alzheimer's disease. " 12/26/2018 - "The intrinsically disordered protein, Tau, is abundant in neurons and contributes to the regulation of the microtubule (MT) and actin network, while its intracellular abnormal aggregation is closely associated with Alzheimer's disease. " 10/01/2018 - "The self-assembly of intrinsically disordered protein tau into paired helical filament forms one of the hallmarks of Alzheimer's disease. " 10/12/2011 - "The intrinsically disordered protein tau becomes excessively phosphorylated and aggregates into neurofibrillary tangles in Alzheimer's disease. "
4.	Neoplasms (Cancer) 12/01/2023 - "Prostate apoptosis response-4 (Par-4), an approximately 40 kilodalton proapoptotic tumor suppressor, is a predominantly intrinsically disordered protein whose downregulation has been observed in various cancers. " 01/01/2023 - "cRTC contains a nanobody against an intrinsically disordered protein TPX2, a microtubule nucleation factor overexpressed in various cancers. " 01/01/2023 - "Intrinsically disordered proteins (IDPs) play important roles in a wide range of biological processes and have been associated with various diseases, including cancer. " 10/15/2022 - "We applied Cancermuts to the intrinsically disordered protein AMBRA1, a key regulator of many cellular processes frequently deregulated in cancer. " 01/01/2022 - "Large-scale cancer genome sequencing has enabled the catalogs of somatic mutations; however, the mutational impact on intrinsically disordered protein regions (IDRs) has not been systematically investigated to date. "
5.	Mental Disorders (Mental Disorder) 01/01/2011 - "Furthermore, this study presents the first evidence supporting the involvement of mutations within intrinsically disordered protein regions in the pathogenesis of psychiatric disorders. " 01/01/2016 - "The aim of the present study was to identify the role and abundance of intrinsically disordered proteins in a set of psychiatric diseases and to test whether diseases are different regarding protein intrinsic disorder. "

Related Drugs and Biologics

1.	Synucleins
2.	Proteins (Proteins, Gene)
3.	Amyloid (Amyloid Fibrils)
4.	alpha-Synuclein
5.	MicroRNAs (MicroRNA)
6.	RNA Helicases (RNA Helicase)
7.	Solvents
8.	Complement System Proteins (Complement)
9.	EWS-FLI fusion protein
10.	Inosine Diphosphate (IDP)

Related Therapies and Procedures

1.	Synchrotrons
2.	Therapeutics
3.	Lasers (Laser)