Multifunctional Enzymes

Molecules that contain multiple active sites which are used to catalyze more than one enzymatic reaction. Proteins in this class generally contain multiple active sites within a single peptide chain and may also contain more than one enzymatically active subunit. They are distinguished from MULTIENZYME COMPLEXES in that their subunits are not found as distinct enzymes.

Also Known As:

Networked: 108 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lipps, Georg: 3 articles (01/2011 - 05/2003)
2.	Dudek, Steven M: 2 articles (01/2015 - 06/2014)
3.	Garcia, Joe G N: 2 articles (01/2015 - 06/2014)
4.	Wang, Ting: 2 articles (01/2015 - 06/2014)
5.	Chehín, Rosana N: 2 articles (05/2014 - 02/2010)
6.	Raz, Avraham: 2 articles (11/2010 - 05/2007)
7.	Bailey, Craig D C: 2 articles (08/2008 - 06/2006)
8.	Johnson, Gail V W: 2 articles (08/2008 - 06/2006)
9.	He, Rui-Zhe: 1 article (04/2022)
10.	Huo, Yan-Miao: 1 article (04/2022)

Related Diseases

1.	Neoplasms (Cancer) 12/21/2021 - "Current Status of the Use of Multifunctional Enzymes as Anti-Cancer Drug Targets." 01/01/2018 - "In addition to altering the metabolic state in cancer cells, some multifunctional enzymes possess non-metabolic functions that also contribute to cell transformation. " 01/01/2018 - "ALDOA is a multifunctional enzyme in the glycolytic pathway and also promotes HIF-1α, which is of importance in hypoxic solid tumors. " 05/30/2013 - "Transglutaminases-2 (Tgase-2) is a group of multifunctional enzymes that plays a role in cancer cell metastasis and bone formation. " 11/15/2017 - "Transglutaminase 2 (TG2) is a ubiquitous multifunctional enzyme whose expression has been found to be altered in numerous studies of apoptosis and cell survival; its activity has been found to be increased in many types of cancer, where it is often over-expressed. "
2.	Obesity 08/24/2007 - "Biotin-dependent multifunctional enzymes carry out metabolically important carboxyl group transfer reactions and are potential targets for the treatment of obesity and type 2 diabetes. " 01/01/2017 - "Serine hydrolases are a large family of multifunctional enzymes known to influence obesity. " 01/01/2013 - "A few studies in adults and adolescents suggest a link between obesity and paraoxonase 1 (PON1), a multifunctional enzyme that can metabolize organophosphate pesticides and also has antioxidant properties. "
3.	Hemorrhage 01/01/2018 - "Although the mechanisms of action of these enzymes are not well understood they are a subject of a variety of studies, because LAAOs are multifunctional enzymes exhibiting a wide range of pharmacological effects, including the inhibition or induction of platelet aggregation, hemolysis and hemorrhage, in addition to the stimulation of apoptosis, the activation of leukocytes and the formation of edema. " 03/01/2008 - "Snake venom metalloproteinases (SVMPs) are multifunctional enzymes involved in several symptoms following snakebite, such as severe local hemorrhage. " 01/01/2015 - "Snake venom metalloproteinase (SVMP) (Echis coloratus (Carpet viper) is a multifunctional enzyme that is involved in producing several symptoms that follow a snakebite, such as severe local hemorrhage, nervous system effects and tissue necrosis. "
4.	Disease Progression 01/01/2021 - "Though molecular and pharmacological studies have implicated TG2 in the induction and severity of EAE, the cell autonomous functions of this multifunctional enzyme during disease progression remains to be elucidated." 06/01/2006 - "Tissue transglutaminase (tTG) is a multifunctional enzyme that contributes to disease progression in mouse models of Huntington's disease (HD), an inherited neurodegenerative disease that shows an age-related onset. "
5.	Hemolysis 01/01/2018 - "Although the mechanisms of action of these enzymes are not well understood they are a subject of a variety of studies, because LAAOs are multifunctional enzymes exhibiting a wide range of pharmacological effects, including the inhibition or induction of platelet aggregation, hemolysis and hemorrhage, in addition to the stimulation of apoptosis, the activation of leukocytes and the formation of edema. "

Related Drugs and Biologics

1.	Protein Glutamine gamma Glutamyltransferase 2
2.	Enzymes
3.	Aryldialkylphosphatase (Paraoxonase)
4.	Organophosphates
5.	Antioxidants
6.	Proteins (Proteins, Gene)
7.	Thrombin
8.	DNA (Deoxyribonucleic Acid)
9.	O-(glucuronic acid 2-sulfate)-(1--3)-O-(2,5)-andydrotalitol 6-sulfate
10.	Fatty Acid Synthases (Fatty Acid Synthase)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)