Cdh1 Proteins

Cdh1 is an activator of the anaphase-promoting complex-cyclosome and is involved in substrate recognition. It associates with the complex in late MITOSIS from anaphase through G1 to regulate activity of CYCLIN-DEPENDENT KINASES and to prevent premature DNA replication.

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Networked: 10 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Babu, Golap: 1 article (07/2022)
2.	Bin Islam, Shad: 1 article (07/2022)
3.	Khan, Md Asaduzzaman: 1 article (07/2022)
4.	Anand, Rishika: 1 article (01/2021)
5.	Bastia, Banajit: 1 article (01/2021)
6.	Choudhary, Saumya: 1 article (01/2021)
7.	Deng, Shishan: 1 article (01/2021)
8.	Jain, Arun Kumar: 1 article (01/2021)
9.	Kumar, Shashi Nandar: 1 article (01/2021)
10.	Lai, Jinrong: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 10/21/2019 - "Molecular interrogation confirmed a mutation in CDH1 exon 12 leading to early truncation of the CDH1 protein in the tumor cells. " 10/01/2011 - "Using a sequencing analysis, a 1-bp deletion (c.1212delC), leading to the production of a truncated protein (p.Asn405IlefsX12), was found in an FGC family; immunohistochemical analysis revealed the loss of CDH1 protein expression in the tumors in this family. " 07/01/2022 - "Genetic polymorphisms in xenobiotic metabolic enzymes (CYP1A1, CYP2A6, CYP3A4, CYP3A5, NAT2, SULT1A), cell cycle regulatory proteins (TP53, HER2, MDM2, miR-218-2, TGFB), cell signaling protein (CDH1), DNA repair proteins (BRCA1, BRCA2, EXO1, RAD51, XRCC2, ECCR1, ERCC4, XPC, ERCC2), and others (HLA-DRB1, INSIG2, GCNT1P5) have been found to be associated with various cancers like cancers of breast, bladder, cervix, colon, lung, prostate, etc. in different studies with Bangladeshi population. "
2.	Carcinoma (Carcinomatosis) 02/01/2020 - "The study results showed that CDH1 mutations, reflected with CDH1 protein loss by immunohistochemistry are detected in 40% of diffuse gastric carcinomas, whilst it is not detected in enteric type gastric carcinomas. "
3.	Stomach Neoplasms (Stomach Cancer) 01/01/2022 - "Decreased amounts of both pT606-Kaiso and CDH1 proteins were frequently observed in human gastric cancer tissues compared to paired normal controls. " 12/01/2014 - "Hereditary diffuse gastric cancer is an autosomic dominant syndrome associated with E-cadherin protein (CDH1) gene germline mutations. "
4.	Microsatellite Instability 11/10/2022 - "The detection rates for microsatellite instability (MSI) and loss of heterozygosity (LOH) at the D16S752 locus and the positive rate of CDH1 protein were 19.39%, 16.33% and 51.02%, respectively. "
5.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 02/01/2012 - "Imatinib and bortezomib induce the expression and distribution of anaphase-promoting complex adaptor protein Cdh1 in blast crisis of chronic myeloid leukemia."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	HLA-DRB1 Chains (HLA DRB1)
3.	Cytochrome P-450 CYP3A
4.	Cytochrome P-450 CYP1A1 (CYP1A1)
5.	Cell Cycle Proteins
6.	Xenobiotics
7.	Enzymes
8.	Anaphase-Promoting Complex-Cyclosome
9.	Cadherins (E-Cadherin)
10.	Bortezomib (Velcade)