Anaphase-Promoting Complex-Cyclosome Apc5 Subunit

A subunit of the anaphase-promoting complex whose primary function is to provide structural support for the catalytic and substrate-recognition modules of the complex. Apc5, along with Apc4, tethers the tetratricopeptide-coactivator binding subcomplex to the main structural subunit, Apc1.

Also Known As:

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cherry, Catherine: 1 article (09/2020)
2.	Gaff, Jessica: 1 article (09/2020)
3.	Kamerman, Peter: 1 article (09/2020)
4.	Laws, Simon M: 1 article (09/2020)
5.	Pillay, Prinisha: 1 article (09/2020)
6.	Price, Patricia: 1 article (09/2020)
7.	Hamamura, R S: 1 article (10/2007)
8.	Kobayashi, C: 1 article (10/2007)
9.	Kurashina, R: 1 article (10/2007)
10.	Ohyashiki, J H: 1 article (10/2007)

Related Diseases

1.	Tuberculosis (Tuberculoses) 09/15/2020 - "Five polymorphisms, rs503720*G (OR = 133) in P2X7R, rs10849861*A (OR = 5.99), rs1653586*T (OR = 67.8) and rs11065504*C (OR = 0.02) in CAMKK2, and rs2089886*A (OR = 6.68) in ANAPC5, associated with HIV-SN after adjusting for body weight, nadir CD4 T-cell counts and prior tuberculosis (model p < 0.0001, n = 69, Pseudo R2 = 0.54). "
2.	Body Weight (Weight, Body) 09/15/2020 - "Five polymorphisms, rs503720*G (OR = 133) in P2X7R, rs10849861*A (OR = 5.99), rs1653586*T (OR = 67.8) and rs11065504*C (OR = 0.02) in CAMKK2, and rs2089886*A (OR = 6.68) in ANAPC5, associated with HIV-SN after adjusting for body weight, nadir CD4 T-cell counts and prior tuberculosis (model p < 0.0001, n = 69, Pseudo R2 = 0.54). "
3.	Hypoxia (Hypoxemia) 10/22/2007 - "An oligonucleotide DNA microarray analysis of TaY cells revealed upregulation of genes encoding heat shock proteins (HSPA1A, STIP1, HSPA1B, and HSPCA), genes related to protein folding (CDC37 and ANAPC5), Fas-associated factor 1(FAF1) and an oxidative stress-related gene, heme oxygenase-1(HMOX-1), known to be a target gene of hypoxia-inducible gene-1 alpha (HIF-1 alpha). "

Related Drugs and Biologics

1.	Oligonucleotides
2.	Heme (Haem)
3.	Heat-Shock Proteins (Heat-Shock Protein)
4.	DNA (Deoxyribonucleic Acid)