Minichromosome Maintenance Complex Component 5

A minichromosome maintenance protein that is a key component of the six member MCM protein complex. In addition, interaction of this protein with cyclin A results in its recruitment to CENTROSOMES where it may play a role in controlling centrosome reduplication.

Also Known As:

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Li, Xiaoxiao: 1 article (01/2022)
2.	Sun, Man: 1 article (01/2022)
3.	Wang, Tao: 1 article (01/2022)
4.	Zhang, Yanmei: 1 article (01/2022)
5.	Zhu, Lichao: 1 article (01/2022)
6.	Zhu, Yonglin: 1 article (01/2022)
7.	Li, Qi: 1 article (01/2021)
8.	Sun, Xiao-Jie: 1 article (01/2021)
9.	Zhang, Lin-Lin: 1 article (01/2021)
10.	Zhang, Wei-Jian: 1 article (01/2021)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 08/01/2023 - "In this study, a key module was identified and four hub genes (MCM5 (encoding minichromosome maintenance complex component 5), NOLC1 (encoding nucleolar and coiled-body phosphoprotein 1), MYC (encoding MYC proto-oncogene, BHLH transcription factor), and CDK4 (encoding cyclin dependent kinase 4)) were selected that correlated with COAD prognosis, based on the GSE9348 dataset in Gene Expression Omnibus database. "
2.	Neoplasms (Cancer) 03/01/2014 - "Mechanism dissection found that targeting ERβ suppressed the expression of minichromosome maintenance complex component 5 (MCM5), a DNA replication licensing factor that is involved in tumor cell growth. " 07/01/2016 - "To expand the library of promoters that can be used for expression-targeted gene delivery to cancer cells, the specificity and strength of expression of three cancer-related gene promoters was evaluated: RAS-related nuclear protein ((P) ran), breast cancer metastasis suppressor 1 ((P) brms1) and minichromosome maintenance complex component 5 ((P) mcm5). "
3.	Breast Neoplasms (Breast Cancer) 06/01/2015 - "MicroRNA-10b and minichromosome maintenance complex component 5 gene as prognostic biomarkers in breast cancer." 07/01/2016 - "To expand the library of promoters that can be used for expression-targeted gene delivery to cancer cells, the specificity and strength of expression of three cancer-related gene promoters was evaluated: RAS-related nuclear protein ((P) ran), breast cancer metastasis suppressor 1 ((P) brms1) and minichromosome maintenance complex component 5 ((P) mcm5). "
4.	Neoplasm Metastasis (Metastasis) 07/01/2016 - "To expand the library of promoters that can be used for expression-targeted gene delivery to cancer cells, the specificity and strength of expression of three cancer-related gene promoters was evaluated: RAS-related nuclear protein ((P) ran), breast cancer metastasis suppressor 1 ((P) brms1) and minichromosome maintenance complex component 5 ((P) mcm5). "
5.	Lung Neoplasms (Lung Cancer) 01/01/2021 - "Herein, we explored the involvement of minichromosome maintenance complex component 5 (MCM5) and HDAC1 interaction in the epithelial-to-mesenchymal transition (EMT)-dependent malignant progression of lung cancer. "

Related Drugs and Biologics

1.	Basic Helix-Loop-Helix Transcription Factors
2.	Cyclin-Dependent Kinase 4
3.	Phosphoproteins
4.	A-Form DNA (A-DNA)
5.	ran GTP-Binding Protein
6.	Biomarkers (Surrogate Marker)