CRISPR-Associated Proteins

Protein components of the CRISPR-CAS SYSTEMS for anti-viral defense in ARCHAEA and BACTERIA. These are proteins that carry out a variety of functions during the creation and expansion of the CRISPR ARRAYS, the capture of new CRISPR SPACERS, biogenesis of SMALL INTERFERING RNA (CRISPR or crRNAs), and the targeting and silencing of invading viruses and plasmids. They include DNA HELICASES; RNA-BINDING PROTEINS; ENDONUCLEASES; and RNA and DNA POLYMERASES.

Also Known As:

CASCADE Proteins, CRISPR-Associated; CRISPR-Associated Complex for Antiviral Defense Proteins; CRISPR-Associated Protein Complex Proteins; Repeat-Associated Mysterious Proteins; CASCADE Proteins, CRISPR Associated; CRISPR Associated Complex for Antiviral Defense Proteins; CRISPR Associated Protein Complex Proteins; CRISPR Associated Proteins; CRISPR-Associated CASCADE Proteins; Proteins, CRISPR-Associated; Proteins, Repeat-Associated Mysterious; Repeat Associated Mysterious Proteins

Networked: 20 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - CRISPR-Associated Proteins: 20

Experts

1.	Feng, Zheng: 1 article (06/2022)
2.	Li, Kui: 1 article (06/2022)
3.	Liu, Zhiguo: 1 article (06/2022)
4.	Mu, Yulian: 1 article (06/2022)
5.	Wang, Bingyuan: 1 article (06/2022)
6.	Wang, Hui: 1 article (06/2022)
7.	Wu, Tianwen: 1 article (06/2022)
8.	Xiang, Guangming: 1 article (06/2022)
9.	Dai, Xuyan: 1 article (04/2022)
10.	Ge, Kun: 1 article (04/2022)

Related Diseases

1.	Inborn Genetic Diseases (Disease, Hereditary) 01/01/2017 - "Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. " 01/01/2022 - "Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) has revolutionized genome editing and has great potential for many applications, such as correcting human genetic disorders. " 01/01/2022 - "Genome-editing technology using Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR associated proteins (CRISPR-Cas9) system is expected to be a therapeutic approach to treat genetic diseases, such as ATTR amyloidosis caused by a point mutation in TTR gene. "
2.	Virus Diseases (Viral Diseases) 01/01/2012 - "The results from these studies showed that the prokaryotic antiviral adaptive immune system CRISPR-associated proteins (CAS proteins) were regulated in response to the virus infection. "
3.	Infections 01/01/2018 - "Bacteria and archaea control HGT and phage infection through CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) adaptive immunity. " 10/01/2015 - "To reduce crop losses due to geminivirus infection, we targeted the bean yellow dwarf virus (BeYDV) genome for destruction with the CRISPR-Cas (clustered, regularly interspaced short palindromic repeats-CRISPR-associated proteins) system. " 10/01/2013 - "In this Review, we describe the various tactics that are used by phages to overcome bacterial resistance mechanisms, including adsorption inhibition, restriction-modification, CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) systems and abortive infection. " 01/01/2012 - "thermophilus, specifically CRISPR-associated proteins, upon phage 2972 infection." 03/01/2020 - "Bacteria use various strategies to overcome the invading phages, including adsorption inhibition, restriction-modification (R/E) systems, CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) systems, abortive infection (Abi), etc. To counteract, phages employ intelligent tactics for the nullification of bacterial defense systems, such as accessing host receptors, evading R/E systems, and anti-CRISPR proteins. "
4.	Communicable Diseases (Infectious Diseases) 12/01/2022 - "Emerging clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) detection systems have shown remarkable potential as next-generation diagnostic tools to achieve rapid, sensitive, specific, and field-deployable diagnoses of infectious diseases, based on state-of-the-art microfluidic platforms. " 04/01/2022 - "The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) system has the potential to address these critical needs for tackling infectious diseases to detect viral nucleic acids and inhibit viral replication. "
5.	Disease Resistance 06/30/2022 - "Here, we reviewed the advancements of the CRISPR (Clustered regularly interspaced short palindromic repeats)/Cas (CRISPR associated proteins) genome editing tools and their applications in animal breeding, especially in improving disease resistance, production performance, and animal welfare. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Antiviral Agents (Antivirals)
3.	Nucleic Acids
4.	DNA Restriction-Modification Enzymes (Restriction Modification Systems)
5.	Fibronectins (Fibronectin)