Calbindin 1

A calcium-binding protein that mediates calcium HOMEOSTASIS in KIDNEYS, BRAIN, and other tissues. It is found in well-defined populations of NEURONS and is involved in CALCIUM SIGNALING and NEURONAL PLASTICITY. It is regulated in some tissues by VITAMIN D.

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Networked: 170 relevant articles (3 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shao, Qingmei: 4 articles (10/2014 - 09/2009)
2.	Vig, Parminder J S: 4 articles (10/2014 - 09/2009)
3.	Lai, Li-Wen: 3 articles (01/2012 - 12/2002)
4.	Lee, Chien-Te: 3 articles (01/2012 - 12/2002)
5.	Lien, Yeong-Hau H: 3 articles (01/2012 - 12/2002)
6.	Bai, Jian: 3 articles (04/2011 - 05/2008)
7.	Ahn, Ji Hyeon: 2 articles (01/2021 - 06/2017)
8.	Lee, Jae-Chul: 2 articles (01/2021 - 06/2017)
9.	Lee, Tae-Kyeong: 2 articles (01/2021 - 06/2017)
10.	Park, Joon Ha: 2 articles (01/2021 - 06/2017)

Related Diseases

1.	Wounds and Injuries (Trauma) 06/01/2014 - "Decreased urinary calbindin 1 levels in proteinuric rats and humans with distal nephron segment injuries." 09/01/1999 - "The protective effects of infection with the calbindin D28K vector in an intact brain may prove to be beneficial during changes in Ca2+ homeostasis caused by neurological trauma associated with aging and certain neurological diseases." 06/01/2014 - "Since it has been demonstrated that decreased urinary calbindin 1 levels are indicative of decreased calbindin 1 kidney expression due to distal nephron segment injuries, calbindin 1 might be a useful urinary biomarker for identifying distal nephron segment injuries." 06/01/2014 - "Since calbindin 1 protein is exclusively localized in the kidney distal nephron segment, it is presumed that its expression is altered during distal nephron segment injuries, resulting in changes in its urinary excretion. " 02/20/2013 - "Basic fibroblast growth factor (bFGF) offers some measure of protection against excitotoxic neuronal injuries by upregulating the expression of the calcium-binding protein calbindin-D28k (Calb). "
2.	Ganglion Cysts (Ganglion) 02/01/2018 - "The present study was designed to determine the distribution, morphology and co-localization of calbindin-D28k (CB) with other neuroactive substances in the coeliac-cranial mesenteric ganglion complex (CCMG) neurons supplying the prepyloric region of the porcine stomach. " 07/01/2013 - "Calbindin D28k is expressed in doubles cones, bipolar cells and in a subpopulation of amacrine and ganglion neurons. " 01/12/2001 - "Thus, unlike calbindin-D28k, NC is not confined to the sympathetic neuron population in the major pelvic ganglion and decreases significantly in old age in both neuronal populations. " 08/01/1995 - "In surgical resection specimens, calbindin-D28k reactivity was evident in populations of poorly differentiated cells of classic (non-nodular) medulloblastomas (16/20) and in mature Purkinje neuronlike phenotypes in medulloblastomas with ganglion cells (4/6) but was absent in desmoplastic medulloblastomas, including in areas of neoplastic neuritogenesis ("pale islands") (0/23). " 01/01/2016 - "The density of calbindin D28k-immunoreactive cells in the ganglion cell layer of the mouse retina was 562 cells/mm(2), 8.18% of calbindin D28k-immunoreactive cells were axon-less displaced amacrine cells, 91.82% were retinal ganglion cells, and approximately 18.17% of mouse retinal ganglion cells expressed calbindin D28k. "
3.	Infections 05/23/1995 - "Ninety-six hours after infection with a replication-defective adenovirus containing the calbindin D28k gene, essentially all cultured hippocampal pyramidal neurons robustly expressed calbindin D28k. " 09/01/1999 - "The protective effects of infection with the calbindin D28K vector in an intact brain may prove to be beneficial during changes in Ca2+ homeostasis caused by neurological trauma associated with aging and certain neurological diseases." 04/18/2023 - " observed alterations in Calb1 and Calb2 expression in this study indicate possible impairments in neuronal Ca2+ buffering and Ca2+ homeostasis as a result of RABV infection and, consequently, possible involvement of calbindin-D28K and calretinin in the neuropathogenesis of rabies." 06/25/1996 - "Expression of calbindin-D28K in motoneuron hybrid cells after retroviral infection with calbindin-D28K cDNA prevents amyotrophic lateral sclerosis IgG-mediated cytotoxicity." 09/01/1999 - "We now report that in vivo hippocampal infection with the calbindin D28K HSV vector increases neuronal survival in the dentate gyrus after application of the antimetabolite 3-acetylpyridine and increases transsynaptic neuronal survival in area CA3 following kainic acid neurotoxicity. "
4.	Parkinson Disease (Parkinson's Disease) 12/01/1995 - "Because the hypothalamic dopaminergic neurons do not degenerate in Parkinson's disease, the present study sought to determine whether these neurons also contain calbindin-D28k. " 09/03/1990 - "The distribution of calbindin-D28K (CaBP)-positive neurons was investigated by immunohistochemistry in 4 controls, 5 cases of Parkinson's disease and a single case of strionigral degeneration. " 09/03/1990 - "Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K." 07/01/1994 - "The vulnerability pattern in the mesencephalon of weaver mutants bears similarities to that described in idiopathic Parkinson's disease or in N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism: Calbindin-D28k may thus delimit a group of dopaminergic neurons resistant to cell death in different conditions. " 03/15/2013 - "Role of calbindin-D28K in estrogen treatment for Parkinson's disease."
5.	Hypoxia (Hypoxemia) 11/30/2012 - "Our study finds a statistically significant decrease in the expression of calbindin-D28k (p<0.05) in PCs in the acute hypoxia group, relative to the control groups. " 05/01/2001 - "The present study demonstrates an abrogating effect of perinatal hypoxia on calbindin-D28k immunoreactivity in cerebellar PCs. " 05/01/2001 - "Hypoxia-induced alterations of calbindin-D28k immunoreactivity are qualitatively similar at all time points and include a distinctive intranuclear localization in subpopulations of PCs. " 05/01/2001 - "We hypothesize that hypoxia results in decreased concentration, or availability of calbindin-D28k in PCs, thereby decreasing their buffering capacity and resulting in increase of intracellular and intranuclear [Ca++]. " 05/01/2001 - "Acute hypoxia-induced alterations of calbindin-D28k immunoreactivity in cerebellar Purkinje cells of the guinea pig fetus at term."

Related Drugs and Biologics

1.	Calcium-Binding Proteins
2.	Calbindins
3.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
4.	Parvalbumins
5.	Proteins (Proteins, Gene)
6.	Calcium
7.	Calbindin 2
8.	Messenger RNA (mRNA)
9.	Neuroprotective Agents
10.	Carrier Proteins (Binding Protein)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Therapeutics
3.	Ketogenic Diet
4.	Electroacupuncture
5.	Absorbable Gelatin Sponge