Collagenous Sprue

A malabsorption syndrome characterized by collagenous mucosal lesions of the SMALL INTESTINE, atrophy of MICROVILLI, severe malabsorption, diarrhea, and MALNUTRITION often refractory to a gluten-free diet.

Also Known As:

Networked: 31 relevant articles (5 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Lymphoma (Lymphomas)
2.	Atrophy
3.	Celiac Disease (Celiac Sprue)
4.	Rare Diseases (Rare Disease)
5.	Lymphocytic Colitis

Experts

1.	Murray, Joseph A: 4 articles (01/2017 - 04/2010)
2.	Rubio-Tapia, Alberto: 3 articles (01/2017 - 04/2010)
3.	Wu, Tsung-Teh: 3 articles (08/2013 - 04/2010)
4.	Mulder, Chris J J: 2 articles (02/2020 - 01/2016)
5.	Del Sordo, Rachele: 1 article (11/2021)
6.	Mocci, Giammarco: 1 article (11/2021)
7.	Moneghini, Dario: 1 article (11/2021)
8.	Oberti, Arianna: 1 article (11/2021)
9.	Villanacci, Vincenzo: 1 article (11/2021)
10.	Das, Debashish: 1 article (10/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Collagenous Sprue:

1.	Glutens (Glutelin)IBA 03/28/2014 - "While coeliac disease is treated using gluten restriction, collagenous sprue is, however, not improved by this intervention. " 12/01/1999 - "A diagnosis fitting to the patient's clinical symptoms of severe malabsorption, would be the rare "collagenous sprue", which is considered to be gluten-insensitive. " 05/01/2001 - "A condition characterized by a refractory enteropathy, not due to lymphoma, ulcerative jejunoileitis or collagenous sprue, but in which gluten sensitivity has been shown previously or could be shown while the patients were on an immunosuppressive therapy should be indicated as refractory CD. " 09/27/1986 - "[Collagenous sprue and ulcerative jejuno-ileitis in a patient with gluten-induced enteropathy]."
2.	SteroidsIBA 10/20/1995 - "This case suggests that steroid administration is an effective treatment of collagenous sprue. " 09/27/1986 - "If the diagnosis of collagenous sprue can be established, therapy with steroids should be attempted. " 04/01/2010 - "Gluten-free diet and steroid treatment are effective therapy for most patients with collagenous sprue."
3.	olmesartanIBA 01/01/2016 - "We report a unique case of olmesartan-induced collagenous sprue in a 79-year-old man that showed complete histological and clinical remission with the sole withdrawal of the incriminating drug. " 11/01/2021 - "Collagenous Sprue and Olmesartan: another pathological condition related to this drug." 01/01/2016 - "Adding Water to the Mill: Olmesartan-Induced Collagenous Sprue-A Case Report and Brief Literature Review." 10/28/2013 - "Angiotensin-II inhibitor (olmesartan)-induced collagenous sprue with resolution following discontinuation of drug."
4.	Cyclosporine (Ciclosporin)FDA LinkGeneric 10/20/1995 - "On maintenance dosage of cyclosporin the histological and clinical remission of the collagenous sprue has now lasted for over 2 years. "
5.	CollagenIBA 10/28/2013 - "Collagenous sprue (CS) is a pattern of small-bowel injury characterized histologically by marked villous blunting, intraepithelial lymphocytes, and thickened sub-epithelial collagen table. " 08/28/2013 - "However, distal duodenal biopsies revealed a thickened band of subepithelial collagen with villous atrophic appearances consistent with collagenous sprue. " 04/01/2011 - "In collagenous sprue, concomitant collagen deposits may also occur in gastric or colonic mucosal sites (or both), indicating that this unusual mucosal process may be very heterogeneous and far more extensive in the intestinal tract than previously appreciated. " 04/01/2010 - "Collagenous sprue (CS) is characterized by the presence of a distinctive band of subepithelial collagen deposition in the small bowel. " 12/16/2009 - "A subset of patients may develop subepithelial collagen deposition, a condition referred to as collagenous sprue. "
6.	AntibodiesIBA 05/01/1999 - "Hyposplenism, antiendomysial antibodies and lymphocytic colitis in collagenous sprue." 08/01/2013 - "Endoscopic biopsies from the duodenum with a histologic diagnosis of collagenous sprue (n = 40 from 35 patients), celiac disease (n = 25), peptic duodenitis (n = 15) and normal duodenum (n = 25) were immunohistochemically stained with IgG4 and CD138 antibodies. " 08/01/2012 - "Intestinal biopsies showed both villous atrophy and variable degrees of mucosal inflammation in 15 patients, and marked subepithelial collagen deposition (collagenous sprue) in 7. Tissue transglutaminase antibodies were not detected. "
7.	Thioguanine (Tioguanine)FDA Link 01/01/2016 - "The first cases of collagenous sprue successfully treated with thioguanine." 02/01/2020 - " opinion: Thioguanine has shown beneficial clinical effects in hematological (particularly leukemia) and several immune-inflammatory diseases including psoriasis, SLE, polycythemia vera, Churg-Strauss syndrome, IBD, collagenous sprue, refractory celiac disease, and autoimmune hepatitis. "
8.	Immunoglobulins (Immunoglobulin)IBA 08/01/2013 - "However, the role of immunoglobulin G4 (IgG4)-positive plasma cells has not been studied in collagenous sprue. " 08/01/2013 - "Increased immunoglobulin G4-positive plasma cells in collagenous sprue." 01/01/2009 - "These findings suggest that the GI tract in patients with selective IgA deficiency can show peculiar histologic changes that mimic celiac disease, collagenous sprue, or lymphocytic colitis, which may be a pattern of injury related to infection or immunoglobulin immunodeficiency-associated autoimmune phenomena."
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/01/2009 - "TNF-alpha antibody treatment in refractory collagenous sprue: report of a case and review of the literature."
10.	Prednisolone (Predate)FDA LinkGeneric 09/01/1973 - "Successful treatment of collagenous sprue with combination of prednisolone and gluten-free diet."

Therapies and Procedures

1.	Gluten-Free Diet 12/01/1999 - "[Long-term collagenous sprue--remission with a gluten-free diet]." 06/19/2000 - "There was no response to a gluten-free diet, and the condition was termed collagenous sprue. " 03/01/2013 - "We report the case of a patient presenting with chronic diarrhea and severe malabsorption who was diagnosed with collagenous sprue, with no response to gluten free diet, but with excellent response to budesonida." 06/01/2009 - "Collagenous sprue (CS) is a rare disease characterized by celiac type small bowel malabsorption that is resistant to gluten free diet (GFD) and is associated with a poor prognosis. " 08/28/2013 - "Clinical and histological resolution of collagenous sprue following gluten-free diet and discontinuation of non-steroidal anti-inflammatory drugs (NSAIDs)."
2.	Nutritional Support (Artificial Feeding) 02/01/2003 - "With improved treatment measures, including modern nutritional support, it is likely that there will be an increased opportunity in future for improved appreciation of the complications of collagenous sprue, specifically, lymphoma."
3.	Therapeutics 09/27/1986 - "If the diagnosis of collagenous sprue can be established, therapy with steroids should be attempted. " 04/01/2010 - "Gluten-free diet and steroid treatment are effective therapy for most patients with collagenous sprue."
4.	Home Parenteral Nutrition 10/01/2014 - "Is because this is not clear that we present a case of a patient with bad absorptive diarrhea and a clinical expression of collagenous sprue, that had a great clinical response to corticosteroids with home parenteral nutrition center. "
5.	Colectomy 01/01/2015 - "One teenager developed collagenous sprue, misinterpreted as a severe relapse of ulcerative colitis (UC) resulting in colectomy. "