Rho Guanine Nucleotide Exchange Factors

Signaling proteins which function as master molecular switches by activating Rho GTPases through conversion of guanine nucleotides. Rho GTPases in turn control many aspects of cell behavior through the regulation of multiple downstream signal transduction pathways.

Also Known As:

ARHGEF1; Cool-1 Protein; PAK-Interacting Exchange Factor beta; Rho Guanine Nucleotide Exchange Factor (GEF) 1; Rho Guanine Nucleotide Exchange Factor 6; Rho Guanine Nucleotide Exchange Factor 7; Rho Guanine Nucleotide Exchange Factor p115; RhoGEF; beta PIX Protein; betaPIX Protein; p115 RhoGEF; p115RhoGEF; Cool 1 Protein; PAK Interacting Exchange Factor beta; PIX Protein, beta; Protein, Cool-1; Protein, beta PIX; Protein, betaPIX; RhoGEF, p115

Networked: 186 relevant articles (1 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Protein Regulators
      - Guanine Nucleotide Exchange Factors: 592
        Rho Guanine Nucleotide Exchange Factors: 186
        Proto-Oncogene Proteins c-vav: 12
        Proto-Oncogene Proteins c-bcr: 8
        Drosophila rtGEF protein
        human ARHGEF1 protein
        human ARHGEF10 protein
        human ARHGEF10L protein
        human ARHGEF11 protein
        human ARHGEF12 protein
        human ARHGEF17 protein
        human ARHGEF18 protein
        human ARHGEF2 protein
        human ARHGEF25 protein
        human ARHGEF3 protein
        human ARHGEF39 protein
        human ARHGEF4 protein
        human ARHGEF5 protein
        human ARHGEF6 protein
        human ARHGEF7 protein
        human ARHGEF9 protein
        human FARP1 protein
        human MCF2L protein
        human OBSCN protein
        human PIX protein
        human PLEKHG1 protein
        mouse Arhgef1 protein
        mouse ARHGEF10 protein
        mouse ARHGEF11 protein
        mouse Arhgef12 protein
        mouse Arhgef15 protein
        mouse Arhgef2 protein
        mouse ARHGEF3 protein
        mouse Arhgef4 protein
        mouse ARHGEF5 protein
        mouse Arhgef6 protein
        mouse Arhgef7 protein
        mouse Arhgef9 protein
        mouse CEP2 protein
        mouse FARP1 protein
        mouse GEFT protein
        mouse Mcf2l protein
        mouse obscn protein
        rat Arhgef12 protein
        rat Arhgef2 protein
        rat arhgef6 protein
        rat Arhgef7 protein
        rat Arhgef9 protein
        rat p63RhoGEF protein
        rat PIX protein
        S pombe Gef1 protein
        S pombe Gef3 protein
        Xenopus ARHGEF12 protein
        Xenopus GEF-H1 protein
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Protein Regulators
      - Guanine Nucleotide Exchange Factors: 592
        Rho Guanine Nucleotide Exchange Factors: 186
        Proto-Oncogene Proteins c-vav: 12
        Proto-Oncogene Proteins c-bcr: 8
        Drosophila rtGEF protein
        human ARHGEF1 protein
        human ARHGEF10 protein
        human ARHGEF10L protein
        human ARHGEF11 protein
        human ARHGEF12 protein
        human ARHGEF17 protein
        human ARHGEF18 protein
        human ARHGEF2 protein
        human ARHGEF25 protein
        human ARHGEF3 protein
        human ARHGEF39 protein
        human ARHGEF4 protein
        human ARHGEF5 protein
        human ARHGEF6 protein
        human ARHGEF7 protein
        human ARHGEF9 protein
        human FARP1 protein
        human MCF2L protein
        human OBSCN protein
        human PIX protein
        human PLEKHG1 protein
        mouse Arhgef1 protein
        mouse ARHGEF10 protein
        mouse ARHGEF11 protein
        mouse Arhgef12 protein
        mouse Arhgef15 protein
        mouse Arhgef2 protein
        mouse ARHGEF3 protein
        mouse Arhgef4 protein
        mouse ARHGEF5 protein
        mouse Arhgef6 protein
        mouse Arhgef7 protein
        mouse Arhgef9 protein
        mouse CEP2 protein
        mouse FARP1 protein
        mouse GEFT protein
        mouse Mcf2l protein
        mouse obscn protein
        rat Arhgef12 protein
        rat Arhgef2 protein
        rat arhgef6 protein
        rat Arhgef7 protein
        rat Arhgef9 protein
        rat p63RhoGEF protein
        rat PIX protein
        S pombe Gef1 protein
        S pombe Gef3 protein
        Xenopus ARHGEF12 protein
        Xenopus GEF-H1 protein

Experts

1.	Kozasa, Tohru: 10 articles (09/2014 - 01/2003)
2.	Suzuki, Nobuchika: 7 articles (01/2016 - 01/2003)
3.	Webb, R Clinton: 7 articles (04/2010 - 10/2004)
4.	Gutkind, J Silvio: 6 articles (01/2022 - 09/2002)
5.	Ying, Zhekang: 6 articles (04/2010 - 10/2004)
6.	Tesmer, John J G: 5 articles (01/2022 - 10/2003)
7.	Torres, Raul M: 5 articles (01/2019 - 07/2007)
8.	Loirand, Gervaise: 4 articles (12/2017 - 02/2010)
9.	Kreutz, Barry: 4 articles (08/2007 - 01/2004)
10.	Grabocka, Elda: 3 articles (01/2016 - 10/2007)

Related Diseases

1.	COVID-19 01/01/2022 - "Although the study has an identified significant association of the ARHGEF1 gene in COVID19; and probable compounds targeting it, using in silico methods, these targets need to be validated by both in vitro and in vivo methods to effectively determine their therapeutic efficacy against the devastating virus." 01/01/2022 - "Integrative multiomics and in silico analysis revealed the role of ARHGEF1 and its screened antagonist in mild and severe COVID-19 patients."
2.	Leukemia 01/01/2017 - "In this study, we focused on the signaling from GPCRs to RhoA via Gα13 and leukemia-associated RhoGEF (LARG). " 01/21/2003 - "In this study, we analyzed the interaction of leukemia-associated RhoGEF (LARG), which also contains RGS domain, with Galpha12 and Galpha13. " 01/01/2017 - "Potentiation of receptor responses induced by prolonged binding of Gα13 and leukemia-associated RhoGEF." 01/01/2017 - "Potentiation of receptor responses induced by prolonged binding of Gα13 and leukemia-associated RhoGEF." 03/01/2016 - "C-RGMa utilizes a Leukemia-associated RhoGEF (LARG)/Rho/Rock pathway to inhibit axonal growth. "
3.	Hypertension (High Blood Pressure) 11/01/2013 - "RhoGEF-mediated vasoconstriction in hypertension." 06/01/2010 - "[The exchange factor Arhgef1: a new target in hypertension]." 09/01/2005 - "Because BS/GS represent the mirror image of derangements involved in hypertension, the reduced RhoGEF expression in BS/GS underlines a major impact of RhoA/ROK pathway on blood pressure regulation and confirms BS/GS as a good human model for exploring mechanisms involved in the pathophysiology of hypertension and remodeling." 01/01/2012 - "Studies to explore angiotensin II (Ang II) and its downstream signaling pathways via Rho guanine nucleotide exchange factors (RhoGEFs) and RhoA signaling are crucial to understanding the mechanisms of smooth muscle contraction leading to hypertension. " 08/01/2007 - "This is the first study demonstrating enhanced PDZ-RhoGEF/RhoA/Rho kinase signaling during hypertension at the level of resistance-sized arteries. "
4.	Breast Neoplasms (Breast Cancer) 10/01/2013 - "PDZ-RhoGEF is essential for CXCR4-driven breast tumor cell motility through spatial regulation of RhoA." 10/01/2013 - "Furthermore, immunohistochemical analysis of human breast tumor tissues shows a significant increase of PRG expression in the invasive areas of the tumors, suggesting that this RhoGEF is associated with breast tumor invasion in vivo." 01/01/2015 - "We found that NGF treatment induced CD44 binding to TrkA at the plasma membrane and subsequent activation of the p115RhoGEF/RhoA/ROCK1 pathway to stimulate breast cancer cell invasion. " 09/30/2014 - "Obscurins are RhoGEF-containing proteins whose downregulation has been implicated in the development and progression of breast cancer. " 08/08/2003 - "In this study we have examined CD44 (a hyaluronan (HA) receptor) interaction with a RhoA-specific guanine nucleotide exchange factor (p115RhoGEF) in human metastatic breast tumor cells (MDA-MB-231 cell line). "
5.	Glioblastoma (Glioblastoma Multiforme) 01/01/2022 - "Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma." 11/26/2020 - "Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies." 10/01/2018 - "PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival." 01/01/2020 - "This study was designed to explore the functional role of FYVE, RhoGEF, and PH domain containing 5 antisense RNA 1 (FGD5-AS1) and the underlying regulatory mechanism in the progression of glioblastoma (GBM). " 10/01/2018 - "PDZ-RhoGEF is overexpressed in glioblastoma tumors and stimulates glioma cell invasion via Rho activation. "

Related Drugs and Biologics

1.	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)
2.	rho-Associated Kinases
3.	Antisense RNA (Anti-Sense RNA)
4.	Hyaluronic Acid (Hyaluronan)
5.	Proteins (Proteins, Gene)
6.	Angiotensin II
7.	Long Noncoding RNA
8.	Trans-Activators (Trans-Acting Factor)
9.	Glucose (Dextrose)
10.	gamma-glutamylaspartic acid

Related Therapies and Procedures

1.	Therapeutics